In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation

Cinnamoyl-containing natural products (CCNPs) are a small class of bacterial metabolites with notable bioactivities. The biosynthesis of cinnamoyl moiety has been proposed to be assembled by an unusual highly reducing (HR) type II polyketide synthases (PKS). However, the biosynthetic route, especial...

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Veröffentlicht in:	Journal of the American Chemical Society 2022-05, Vol.144 (17), p.7939-7948
Hauptverfasser:	Shi, Jing, Shi, Yang, Li, Jian Cheng, Wei, Wanqing, Chen, Yu, Cheng, Ping, Liu, Cheng Li, Zhang, Hao, Wu, Rui, Zhang, Bo, Jiao, Rui Hua, Yu, Shouyun, Liang, Yong, Tan, Ren Xiang, Ge, Hui Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzene Biological Products - metabolism Cyclization Multigene Family Polyenes Polyketide Synthases - metabolism
Online-Zugang:	Volltext
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