CD5-positive marginal zone lymphoma: Clinicopathological features and survival outcomes
CD5 expression in different B-cell lymphomas has different clinicopathological and prognosis and the value of CD5 expression in marginal zone lymphoma is undefined. Clinicopathological features, survival outcomes of marginal zone lymphoma were retrospectively analyzed in 204 patients. We classified...
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| Veröffentlicht in: | Leukemia research 2022-06, Vol.117, p.106840-106840, Article 106840 |
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| container_title | Leukemia research |
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| creator | Xia, Yaqin Ge, Jurui Sun, Zhenchang Nan, Feifei Wan, Wenjuan Xu, Duo Zhang, Mingzhi Fu, Xiaorui |
| description | CD5 expression in different B-cell lymphomas has different clinicopathological and prognosis and the value of CD5 expression in marginal zone lymphoma is undefined.
Clinicopathological features, survival outcomes of marginal zone lymphoma were retrospectively analyzed in 204 patients. We classified patients into (i) CD5-positive marginal zone lymphoma (ii) CD5-negative marginal zone Lymphoma, Fisher's exact test was used to compare the CD5-positive and CD5-negative marginal zone lymphoma. Progression-free survival (PFS) and overall survival (OS) curves were summarized by Kaplan-Meier method and compared using the log-rank test.
Of the 204 patients, 48 (23.53%) were CD5-positive. The 5-year PFS and OS rates for CD5-positive marginal zone lymphoma were 64.80% and 84.10%, there was no significant difference between CD5-positive and CD5-negative (P > 0.05). Diffuse large B cell lymphoma (DLBCL) transformation was pathologically indicated in 6 patients, of which 5 (83.33%) patients were CD5-positive marginal zone lymphoma.
CD5 expression in marginal zone lymphoma is not relevant to the prognosis of the patients, but CD5-positive marginal zone lymphoma seems more likely to transformation to diffuse large B-cell lymphoma.
•CD5 expression in marginal zone lymphoma is not revelent to the prognosis of patients.•CD5-positive and CD5-negitave MZL have similar clinical features.•CD5-positive MZL seems more likely to transformation to DLBCL. |
| doi_str_mv | 10.1016/j.leukres.2022.106840 |
| format | Article |
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Clinicopathological features, survival outcomes of marginal zone lymphoma were retrospectively analyzed in 204 patients. We classified patients into (i) CD5-positive marginal zone lymphoma (ii) CD5-negative marginal zone Lymphoma, Fisher's exact test was used to compare the CD5-positive and CD5-negative marginal zone lymphoma. Progression-free survival (PFS) and overall survival (OS) curves were summarized by Kaplan-Meier method and compared using the log-rank test.
Of the 204 patients, 48 (23.53%) were CD5-positive. The 5-year PFS and OS rates for CD5-positive marginal zone lymphoma were 64.80% and 84.10%, there was no significant difference between CD5-positive and CD5-negative (P > 0.05). Diffuse large B cell lymphoma (DLBCL) transformation was pathologically indicated in 6 patients, of which 5 (83.33%) patients were CD5-positive marginal zone lymphoma.
CD5 expression in marginal zone lymphoma is not relevant to the prognosis of the patients, but CD5-positive marginal zone lymphoma seems more likely to transformation to diffuse large B-cell lymphoma.
•CD5 expression in marginal zone lymphoma is not revelent to the prognosis of patients.•CD5-positive and CD5-negitave MZL have similar clinical features.•CD5-positive MZL seems more likely to transformation to DLBCL.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2022.106840</identifier><identifier>PMID: 35468520</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>CD5 ; DLBCL ; MZL ; Transformation</subject><ispartof>Leukemia research, 2022-06, Vol.117, p.106840-106840, Article 106840</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-2b27b70560c4560a666ce7d52c24de0af6f6b775e891c7645fb0c024efdef0403</citedby><cites>FETCH-LOGICAL-c342t-2b27b70560c4560a666ce7d52c24de0af6f6b775e891c7645fb0c024efdef0403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145212622000662$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35468520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Yaqin</creatorcontrib><creatorcontrib>Ge, Jurui</creatorcontrib><creatorcontrib>Sun, Zhenchang</creatorcontrib><creatorcontrib>Nan, Feifei</creatorcontrib><creatorcontrib>Wan, Wenjuan</creatorcontrib><creatorcontrib>Xu, Duo</creatorcontrib><creatorcontrib>Zhang, Mingzhi</creatorcontrib><creatorcontrib>Fu, Xiaorui</creatorcontrib><title>CD5-positive marginal zone lymphoma: Clinicopathological features and survival outcomes</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>CD5 expression in different B-cell lymphomas has different clinicopathological and prognosis and the value of CD5 expression in marginal zone lymphoma is undefined.
Clinicopathological features, survival outcomes of marginal zone lymphoma were retrospectively analyzed in 204 patients. We classified patients into (i) CD5-positive marginal zone lymphoma (ii) CD5-negative marginal zone Lymphoma, Fisher's exact test was used to compare the CD5-positive and CD5-negative marginal zone lymphoma. Progression-free survival (PFS) and overall survival (OS) curves were summarized by Kaplan-Meier method and compared using the log-rank test.
Of the 204 patients, 48 (23.53%) were CD5-positive. The 5-year PFS and OS rates for CD5-positive marginal zone lymphoma were 64.80% and 84.10%, there was no significant difference between CD5-positive and CD5-negative (P > 0.05). Diffuse large B cell lymphoma (DLBCL) transformation was pathologically indicated in 6 patients, of which 5 (83.33%) patients were CD5-positive marginal zone lymphoma.
CD5 expression in marginal zone lymphoma is not relevant to the prognosis of the patients, but CD5-positive marginal zone lymphoma seems more likely to transformation to diffuse large B-cell lymphoma.
•CD5 expression in marginal zone lymphoma is not revelent to the prognosis of patients.•CD5-positive and CD5-negitave MZL have similar clinical features.•CD5-positive MZL seems more likely to transformation to DLBCL.</description><subject>CD5</subject><subject>DLBCL</subject><subject>MZL</subject><subject>Transformation</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMoun78BKVHL10naZJ2vYisnyB4UTyGNJ3uZm2bmrQL-uuN7OrVywwMz8zLPIScUphSoPJiNW1wfPcYpgwYizNZcNghE1rkWSqKTOySCVAuUkaZPCCHIawAQMzobJ8cZILLQjCYkLf5jUh7F-xg15i02i9sp5vky3WYNJ9tv3Stvkzmje2scb0elq5xC2siUqMexpif6K5KwujXdh2nbhyMazEck71aNwFPtv2IvN7dvswf0qfn-8f59VNqMs6GlJUsL3MQEgyPRUspDeaVYIbxCkHXspZlngssZtTkkou6BAOMY11hDRyyI3K-udt79zFiGFRrg8Gm0R26MSgmhYiH5SyLqNigxrsQPNaq9zZ-_KkoqB-naqW2TtWPU7VxGvfOthFj2WL1t_UrMQJXGwDjo2uLXgVjsTNYWY9mUJWz_0R8A1Yri6E</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Xia, Yaqin</creator><creator>Ge, Jurui</creator><creator>Sun, Zhenchang</creator><creator>Nan, Feifei</creator><creator>Wan, Wenjuan</creator><creator>Xu, Duo</creator><creator>Zhang, Mingzhi</creator><creator>Fu, Xiaorui</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202206</creationdate><title>CD5-positive marginal zone lymphoma: Clinicopathological features and survival outcomes</title><author>Xia, Yaqin ; Ge, Jurui ; Sun, Zhenchang ; Nan, Feifei ; Wan, Wenjuan ; Xu, Duo ; Zhang, Mingzhi ; Fu, Xiaorui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-2b27b70560c4560a666ce7d52c24de0af6f6b775e891c7645fb0c024efdef0403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>CD5</topic><topic>DLBCL</topic><topic>MZL</topic><topic>Transformation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Yaqin</creatorcontrib><creatorcontrib>Ge, Jurui</creatorcontrib><creatorcontrib>Sun, Zhenchang</creatorcontrib><creatorcontrib>Nan, Feifei</creatorcontrib><creatorcontrib>Wan, Wenjuan</creatorcontrib><creatorcontrib>Xu, Duo</creatorcontrib><creatorcontrib>Zhang, Mingzhi</creatorcontrib><creatorcontrib>Fu, Xiaorui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Yaqin</au><au>Ge, Jurui</au><au>Sun, Zhenchang</au><au>Nan, Feifei</au><au>Wan, Wenjuan</au><au>Xu, Duo</au><au>Zhang, Mingzhi</au><au>Fu, Xiaorui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD5-positive marginal zone lymphoma: Clinicopathological features and survival outcomes</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2022-06</date><risdate>2022</risdate><volume>117</volume><spage>106840</spage><epage>106840</epage><pages>106840-106840</pages><artnum>106840</artnum><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>CD5 expression in different B-cell lymphomas has different clinicopathological and prognosis and the value of CD5 expression in marginal zone lymphoma is undefined.
Clinicopathological features, survival outcomes of marginal zone lymphoma were retrospectively analyzed in 204 patients. We classified patients into (i) CD5-positive marginal zone lymphoma (ii) CD5-negative marginal zone Lymphoma, Fisher's exact test was used to compare the CD5-positive and CD5-negative marginal zone lymphoma. Progression-free survival (PFS) and overall survival (OS) curves were summarized by Kaplan-Meier method and compared using the log-rank test.
Of the 204 patients, 48 (23.53%) were CD5-positive. The 5-year PFS and OS rates for CD5-positive marginal zone lymphoma were 64.80% and 84.10%, there was no significant difference between CD5-positive and CD5-negative (P > 0.05). Diffuse large B cell lymphoma (DLBCL) transformation was pathologically indicated in 6 patients, of which 5 (83.33%) patients were CD5-positive marginal zone lymphoma.
CD5 expression in marginal zone lymphoma is not relevant to the prognosis of the patients, but CD5-positive marginal zone lymphoma seems more likely to transformation to diffuse large B-cell lymphoma.
•CD5 expression in marginal zone lymphoma is not revelent to the prognosis of patients.•CD5-positive and CD5-negitave MZL have similar clinical features.•CD5-positive MZL seems more likely to transformation to DLBCL.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35468520</pmid><doi>10.1016/j.leukres.2022.106840</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | CD5 DLBCL MZL Transformation |
| title | CD5-positive marginal zone lymphoma: Clinicopathological features and survival outcomes |
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