Significant impact of a history of prior or concomitant upper urinary tract cancer on the recurrence and progression of non-muscle invasive bladder cancer
Abstract Background The objective of the present study was to evaluate the prognostic impact of the upper urinary tract cancer status on recurrence-free survival and progression-free survival, and to develop risk stratification systems that include the upper urinary tract cancer status for patients...
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| Veröffentlicht in: | Japanese journal of clinical oncology 2022-08, Vol.52 (8), p.944-949 |
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| container_title | Japanese journal of clinical oncology |
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| creator | Matsushita, Yuto Kawakami, Asuka Sato, Ryo Watanabe, Kyohei Watanabe, Hiromitsu Tamura, Keita Motoyama, Daisuke Ito, Toshiki Sugiyama, Takayuki Otsuka, Atsushi Miyake, Hideaki |
| description | Abstract
Background
The objective of the present study was to evaluate the prognostic impact of the upper urinary tract cancer status on recurrence-free survival and progression-free survival, and to develop risk stratification systems that include the upper urinary tract cancer status for patients with non-muscle invasive bladder cancer.
Patients and Methods
The present study included 40 (upper urinary tract cancer-non-muscle invasive bladder cancer group) and 285 (non-muscle invasive bladder cancer alone group) patients with and without a history of prior or concomitant upper urinary tract cancer, respectively. Nine clinicopathological findings between the two groups were compared, and risk stratification systems for the recurrence and progression of non-muscle invasive bladder cancer were developed.
Results
Recurrence-free survival and progression-free survival in the upper urinary tract cancer-non-muscle invasive bladder cancer group were significantly inferior to those in the NMIBC alone group (P |
| doi_str_mv | 10.1093/jjco/hyac068 |
| format | Article |
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Background
The objective of the present study was to evaluate the prognostic impact of the upper urinary tract cancer status on recurrence-free survival and progression-free survival, and to develop risk stratification systems that include the upper urinary tract cancer status for patients with non-muscle invasive bladder cancer.
Patients and Methods
The present study included 40 (upper urinary tract cancer-non-muscle invasive bladder cancer group) and 285 (non-muscle invasive bladder cancer alone group) patients with and without a history of prior or concomitant upper urinary tract cancer, respectively. Nine clinicopathological findings between the two groups were compared, and risk stratification systems for the recurrence and progression of non-muscle invasive bladder cancer were developed.
Results
Recurrence-free survival and progression-free survival in the upper urinary tract cancer-non-muscle invasive bladder cancer group were significantly inferior to those in the NMIBC alone group (P < 0.001 and P = 0.006, respectively). Multivariate analyses identified the following independent prognosticators: multiplicity and upper urinary tract cancer status for recurrence-free survival, and pT category and upper urinary tract cancer status for progression-free survival. Significant differences were noted by the risk stratification systems based on the positive number of independent predictors of recurrence-free survival and progression-free survival (P < 0.001 and P = 0.007, respectively). The concordance indices of recurrence-free survival were 0.627, 0.588 and 0.499 in this study stratification, EORTC risk table and CUETO model, respectively. Those of progression-free survival were 0.752, 0.740 and 0.714, respectively.
Conclusion
The present results suggest the significant impact of a history of prior or concomitant UUTC on recurrence-free survival and progression-free survival in non-muscle invasive bladder cancer patients, and risk stratification systems that include the upper urinary tract cancer status for the recurrence and progression of non-muscle invasive bladder cancer are promising tools for predicting the outcomes of these patients.
A history of prior or concomitant upper urinary tract cancer was shown to have a significant impact on recurrence- and progression-free survival in non-muscle invasive bladder cancer patients.</description><identifier>ISSN: 1465-3621</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyac068</identifier><identifier>PMID: 35462401</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Japanese journal of clinical oncology, 2022-08, Vol.52 (8), p.944-949</ispartof><rights>The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c304t-53e848e0c815c23adf61e61230dd1d98752f7f5ecc90300800e8d2cf178977363</cites><orcidid>0000-0002-8159-9793 ; 0000-0002-4305-7328 ; 0000-0002-1340-4739 ; 0000-0002-1171-9948</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35462401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsushita, Yuto</creatorcontrib><creatorcontrib>Kawakami, Asuka</creatorcontrib><creatorcontrib>Sato, Ryo</creatorcontrib><creatorcontrib>Watanabe, Kyohei</creatorcontrib><creatorcontrib>Watanabe, Hiromitsu</creatorcontrib><creatorcontrib>Tamura, Keita</creatorcontrib><creatorcontrib>Motoyama, Daisuke</creatorcontrib><creatorcontrib>Ito, Toshiki</creatorcontrib><creatorcontrib>Sugiyama, Takayuki</creatorcontrib><creatorcontrib>Otsuka, Atsushi</creatorcontrib><creatorcontrib>Miyake, Hideaki</creatorcontrib><title>Significant impact of a history of prior or concomitant upper urinary tract cancer on the recurrence and progression of non-muscle invasive bladder cancer</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>Abstract
Background
The objective of the present study was to evaluate the prognostic impact of the upper urinary tract cancer status on recurrence-free survival and progression-free survival, and to develop risk stratification systems that include the upper urinary tract cancer status for patients with non-muscle invasive bladder cancer.
Patients and Methods
The present study included 40 (upper urinary tract cancer-non-muscle invasive bladder cancer group) and 285 (non-muscle invasive bladder cancer alone group) patients with and without a history of prior or concomitant upper urinary tract cancer, respectively. Nine clinicopathological findings between the two groups were compared, and risk stratification systems for the recurrence and progression of non-muscle invasive bladder cancer were developed.
Results
Recurrence-free survival and progression-free survival in the upper urinary tract cancer-non-muscle invasive bladder cancer group were significantly inferior to those in the NMIBC alone group (P < 0.001 and P = 0.006, respectively). Multivariate analyses identified the following independent prognosticators: multiplicity and upper urinary tract cancer status for recurrence-free survival, and pT category and upper urinary tract cancer status for progression-free survival. Significant differences were noted by the risk stratification systems based on the positive number of independent predictors of recurrence-free survival and progression-free survival (P < 0.001 and P = 0.007, respectively). The concordance indices of recurrence-free survival were 0.627, 0.588 and 0.499 in this study stratification, EORTC risk table and CUETO model, respectively. Those of progression-free survival were 0.752, 0.740 and 0.714, respectively.
Conclusion
The present results suggest the significant impact of a history of prior or concomitant UUTC on recurrence-free survival and progression-free survival in non-muscle invasive bladder cancer patients, and risk stratification systems that include the upper urinary tract cancer status for the recurrence and progression of non-muscle invasive bladder cancer are promising tools for predicting the outcomes of these patients.
A history of prior or concomitant upper urinary tract cancer was shown to have a significant impact on recurrence- and progression-free survival in non-muscle invasive bladder cancer patients.</description><issn>1465-3621</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU1r3DAQhkVpaD7aW89Ft-YQZ0eWZWuPJSRpIdBD0rNRRuOsFltyJDuwfyW_NjK7DT0VBJJGzzyIdxj7KuBSwFqutlsMq83OINT6AzsRVa0KWZfi4z_nY3aa0hYAlK6aT-xYqqouKxAn7PXePXnXOTR-4m4YDU48dNzwjUtTiLvlMkYXIs8Lg8cwuGlh53GkyOfovMnUFJfGLMFcDJ5PG-KRcI6Rcokbb7MlPEVKyeXnLPXBF8OcsCfu_ItJ7oX4Y2-szYK95zM76kyf6MthP2N_bq4frn4Wd79vf139uCtQQjUVSpKuNAFqobCUxna1oFqUEqwVdq0bVXZNpwhxDRJAA5C2JXai0eumkbU8Y-d7b_7h80xpageXkPreeApzastaKQGy0U1GL_YoxpBSpK7N2Qw5gFZAu0yjXabRHqaR8W8H8_w4kH2H_8afge97IMzj_1VvS2iXgA</recordid><startdate>20220805</startdate><enddate>20220805</enddate><creator>Matsushita, Yuto</creator><creator>Kawakami, Asuka</creator><creator>Sato, Ryo</creator><creator>Watanabe, Kyohei</creator><creator>Watanabe, Hiromitsu</creator><creator>Tamura, Keita</creator><creator>Motoyama, Daisuke</creator><creator>Ito, Toshiki</creator><creator>Sugiyama, Takayuki</creator><creator>Otsuka, Atsushi</creator><creator>Miyake, Hideaki</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8159-9793</orcidid><orcidid>https://orcid.org/0000-0002-4305-7328</orcidid><orcidid>https://orcid.org/0000-0002-1340-4739</orcidid><orcidid>https://orcid.org/0000-0002-1171-9948</orcidid></search><sort><creationdate>20220805</creationdate><title>Significant impact of a history of prior or concomitant upper urinary tract cancer on the recurrence and progression of non-muscle invasive bladder cancer</title><author>Matsushita, Yuto ; Kawakami, Asuka ; Sato, Ryo ; Watanabe, Kyohei ; Watanabe, Hiromitsu ; Tamura, Keita ; Motoyama, Daisuke ; Ito, Toshiki ; Sugiyama, Takayuki ; Otsuka, Atsushi ; Miyake, Hideaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-53e848e0c815c23adf61e61230dd1d98752f7f5ecc90300800e8d2cf178977363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsushita, Yuto</creatorcontrib><creatorcontrib>Kawakami, Asuka</creatorcontrib><creatorcontrib>Sato, Ryo</creatorcontrib><creatorcontrib>Watanabe, Kyohei</creatorcontrib><creatorcontrib>Watanabe, Hiromitsu</creatorcontrib><creatorcontrib>Tamura, Keita</creatorcontrib><creatorcontrib>Motoyama, Daisuke</creatorcontrib><creatorcontrib>Ito, Toshiki</creatorcontrib><creatorcontrib>Sugiyama, Takayuki</creatorcontrib><creatorcontrib>Otsuka, Atsushi</creatorcontrib><creatorcontrib>Miyake, Hideaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsushita, Yuto</au><au>Kawakami, Asuka</au><au>Sato, Ryo</au><au>Watanabe, Kyohei</au><au>Watanabe, Hiromitsu</au><au>Tamura, Keita</au><au>Motoyama, Daisuke</au><au>Ito, Toshiki</au><au>Sugiyama, Takayuki</au><au>Otsuka, Atsushi</au><au>Miyake, Hideaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significant impact of a history of prior or concomitant upper urinary tract cancer on the recurrence and progression of non-muscle invasive bladder cancer</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>Jpn J Clin Oncol</addtitle><date>2022-08-05</date><risdate>2022</risdate><volume>52</volume><issue>8</issue><spage>944</spage><epage>949</epage><pages>944-949</pages><issn>1465-3621</issn><eissn>1465-3621</eissn><abstract>Abstract
Background
The objective of the present study was to evaluate the prognostic impact of the upper urinary tract cancer status on recurrence-free survival and progression-free survival, and to develop risk stratification systems that include the upper urinary tract cancer status for patients with non-muscle invasive bladder cancer.
Patients and Methods
The present study included 40 (upper urinary tract cancer-non-muscle invasive bladder cancer group) and 285 (non-muscle invasive bladder cancer alone group) patients with and without a history of prior or concomitant upper urinary tract cancer, respectively. Nine clinicopathological findings between the two groups were compared, and risk stratification systems for the recurrence and progression of non-muscle invasive bladder cancer were developed.
Results
Recurrence-free survival and progression-free survival in the upper urinary tract cancer-non-muscle invasive bladder cancer group were significantly inferior to those in the NMIBC alone group (P < 0.001 and P = 0.006, respectively). Multivariate analyses identified the following independent prognosticators: multiplicity and upper urinary tract cancer status for recurrence-free survival, and pT category and upper urinary tract cancer status for progression-free survival. Significant differences were noted by the risk stratification systems based on the positive number of independent predictors of recurrence-free survival and progression-free survival (P < 0.001 and P = 0.007, respectively). The concordance indices of recurrence-free survival were 0.627, 0.588 and 0.499 in this study stratification, EORTC risk table and CUETO model, respectively. Those of progression-free survival were 0.752, 0.740 and 0.714, respectively.
Conclusion
The present results suggest the significant impact of a history of prior or concomitant UUTC on recurrence-free survival and progression-free survival in non-muscle invasive bladder cancer patients, and risk stratification systems that include the upper urinary tract cancer status for the recurrence and progression of non-muscle invasive bladder cancer are promising tools for predicting the outcomes of these patients.
A history of prior or concomitant upper urinary tract cancer was shown to have a significant impact on recurrence- and progression-free survival in non-muscle invasive bladder cancer patients.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35462401</pmid><doi>10.1093/jjco/hyac068</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8159-9793</orcidid><orcidid>https://orcid.org/0000-0002-4305-7328</orcidid><orcidid>https://orcid.org/0000-0002-1340-4739</orcidid><orcidid>https://orcid.org/0000-0002-1171-9948</orcidid></addata></record> |
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| title | Significant impact of a history of prior or concomitant upper urinary tract cancer on the recurrence and progression of non-muscle invasive bladder cancer |
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