BET bromodomain inhibitors

Lysine acetylation creates docking sites for epigenetic reader domains of BET bromodomain proteins that have emerged as principal regulators of linage specific gene transcription. The development of potent and highly selective inhibitors, that have been soon widely available, enabled mechanistic stu...

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Veröffentlicht in:	Current opinion in chemical biology 2022-06, Vol.68, p.102148-102148, Article 102148
Hauptverfasser:	Schwalm, Martin P., Knapp, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antineoplastic Agents BET BRD4 Bromodomain JQ1 Lysine - metabolism PROTAC Protein Domains Transcription Factors - metabolism
Online-Zugang:	Volltext
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