High‐copy genome integration and stable production of p‐coumaric acid via a POT1‐mediated strategy in Saccharomyces cerevisiae

Aims To overcome the defective unstable production of p‐coumaric acid (p‐CA) using episomal plasmids and simultaneously achieve genetic stability and high‐copy integration in Saccharomyces cerevisiae. Methods and results Two‐micron plasmids were used to obtain high titres of p‐CA, but p‐CA productio...

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