Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial

WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed to examine whether dolutegravir is non-inferior to darunavir, the best-in-class protease inhibitor dru...

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Veröffentlicht in:	The lancet HIV 2022-06, Vol.9 (6), p.e381-e393
Hauptverfasser:	Paton, Nicholas I, Musaazi, Joseph, Kityo, Cissy, Walimbwa, Stephen, Hoppe, Anne, Balyegisawa, Apolo, Asienzo, Jesca, Kaimal, Arvind, Mirembe, Grace, Lugemwa, Abbas, Ategeka, Gilbert, Borok, Margaret, Mugerwa, Henry, Siika, Abraham, Odongpiny, Eva Laker A, Castelnuovo, Barbara, Kiragga, Agnes, Kambugu, Andrew, Kiiza, Daniel, Kisembo, John, Nsubuga, John, Okwero, Max, Muyise, Rhona, Nasaazi, Claire, Nakiboneka, Dridah L., Namusanje, Josephine, Najjuuko, Theresa, Masaba, Timothy, Serumaga, Timothy, Alinaitwe, Adolf, Arinda, Allan, Rweyora, Angela, Kangah, Mary Goretti, Kasozi, Mariam, Tukumushabe, Phionah, Akunda, Rogers, Makumbi, Shafic, Musumba, Sharif, Myalo, Sula, Ahuura, John, Namusisi, Annet Mary, Kibirige, Daniel, Kiweewa, Francis, Mabonga, Habert, Wandege, Joseph, Nakakeeto, Josephine, Namubiru, Sharon, Nansalire, Winfred, Siika, Abraham Mosigisi, Kwobah, Charles Meja, Mboya, Chris Sande, Mokaya, Martha Mokeira Bisieri, Karoney, Mercy Jelagat, Cheruiyot, Priscilla Chepkorir, Cherutich, Salinah, Njuguna, Simon Wachira, Kirui, Viola Cherotich, Chidziva, Ennie, Musoro, Godfrey, Bhiri, Joyline, Phiri, Misheck, Mudzingwa, Shepherd, Manyanga, Tadios, Banegura, Anchilla Mary, Agwang, Betty, Isaaya, Brian, Tumwine, Constantine, Odongpiny, Eva Laker A., Paton, Nicholas, Senkungu, Peter, Kamara, Yvonne, Amperiize, Mathius, Allen, Elizabeth, Opondo, Charles, Mohammed, Perry, van Rein-van der Horst, Willemijn, Van Delft, Yvon, Boateng, Fafa Addo, Namara, Doreen, Kaleebu, Pontiano, Ojoo, Sylvia, Bwakura, Tapiwanashe, Katana, Milly, Venter, Francois, Walker, Sarah
Format:	Artikel
Sprache:	eng
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