Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts

Most cases of hepatocellular carcinoma (HCC) arise with the fibrotic microenvironment where hepatic stellate cells (HSCs) and carcinoma-associated fibroblasts (CAFs) are critical components in HCC progression. Therefore, CAF normalization could be a feasible therapy for HCC. Galectin-1 (Gal-1), a β-...

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Veröffentlicht in:	Oncogene 2022-05, Vol.41 (21), p.3011-3023
Hauptverfasser:	Tsai, Yao-Tsung, Li, Chih-Yi, Huang, Yen-Hua, Chang, Te-Sheng, Lin, Chung-Yen, Chuang, Chia-Hsien, Wang, Chih-Yang, Anuraga, Gangga, Chang, Tzu-Hao, Shih, Tsung-Chieh, Lin, Zu-Yau, Chen, Yuh-Ling, Chung, Ivy, Lee, Kuen-Haur, Chang, Che-Chang, Sung, Shian-Ying, Yang, Kai-Huei, Tsui, Wan-Lin, Yap, Chee-Voon, Wu, Ming-Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 14/19 38/1 38/61 38/89 38/91 42/109 42/89 631/250/127 631/80/458/1524 96/21 96/95 Apoptosis c-Jun protein Cancer Cancer-Associated Fibroblasts - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell culture Cell Line, Tumor Fibroblasts Fibroblasts - metabolism Fibrosis Galectin 1 - genetics Galectin 1 - metabolism Galectin-1 Gene silencing Hepatocellular carcinoma Hepatoma Human Genetics Humans Inflammation Internal Medicine Liver Liver cancer Liver Neoplasms - pathology Medicine Medicine & Public Health Metalloproteinase Microenvironments Oncology Paracrine signalling Plasminogen activator inhibitors Protein Stability Receptors, Tumor Necrosis Factor, Type I - metabolism Stellate cells Stroma Transcription factors Tumor Microenvironment Tumor necrosis factor receptors Tumor necrosis factor-α Tumors Xenografts
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