Alleviation of doxorubicin-induced cardiomyocyte death through miR-147-y-mediated mitophagy

Doxorubicin (DOX) is a commonly used antitumor drug. However, it may cause severe cardiotoxicity, apoptosis being a major change. A recent report indicates that miR-147 expression is decreased in the myocardium of a myocardial infarction model, suggesting a potential role of this miRNA in DOX-induce...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 2022-06, Vol.609, p.176-182
Hauptverfasser:	Gao, Hongbin, Xian, Gaopeng, Zhong, Guoheng, Huang, Bihong, Liang, Shi, Zeng, Qingchun, Liu, Yungang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cardiomyocyte Caspase 3 - metabolism Doxorubicin Doxorubicin - metabolism Doxorubicin - pharmacology MicroRNAs - metabolism miR-147-y Mitophagy Myocytes, Cardiac - metabolism Protein Kinases - metabolism Swine Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!