Conformational Constrained 4‑(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations

Tertiary C797S mutation of epidermal growth factor receptor (EGFR)-mediated resistance in non-small-cell-lung-cancer (NSCLC) patients is still an unmet clinical need. Several classes of adenosine 5′-triphosphate-competitive or allosteric EGFRT790M/C797S inhibitors and degraders have been developed,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2022-05, Vol.65 (9), p.6840-6858
Hauptverfasser:	Chen, Hao, Lai, Mengzhen, Zhang, Tao, Chen, Yuqing, Tong, Linjiang, Zhu, Sujie, Zhou, Yang, Ren, Xiaomei, Ding, Jian, Xie, Hua, Lu, Xiaoyun, Ding, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Drug Resistance, Neoplasm ErbB Receptors Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mutation Protein Kinase Inhibitors - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!