Linc-ROR genetic variants are associated with the advanced disease in oral squamous cell carcinoma

Linc-ROR genetic variants are associated with the advanced disease in oral squamous cell carcinoma

The objective of this study is to identify the association between linc-ROR genetic variants and oral squamous cell carcinoma tumorigenesis. Four genetic variants of linc-ROR (rs6420545, rs4801078, rs1942348, and rs9636089) were analyzed in 178 OSCCs and 191 controls of the South Indian population b...

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Veröffentlicht in:Archives of oral biology 2022-07, Vol.139, p.105428-105428, Article 105428
Hauptverfasser: Rose, Mathew Maria, Dhamodharan, Shankar, Bharath, Govindaswamy, Murali, Kannan, Subbiah, Shanmugam, Bhaskar, Lakkakula VKS, Murugan, Avaniyapuram Kannan, Munirajan, Arasambattu Kannan
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Genetic variants
Linc-ROR
Long non-coding RNA
Oral cancer
Tobacco
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container_title Archives of oral biology
container_volume 139
creator Rose, Mathew Maria
Dhamodharan, Shankar
Bharath, Govindaswamy
Murali, Kannan
Subbiah, Shanmugam
Bhaskar, Lakkakula VKS
Murugan, Avaniyapuram Kannan
Munirajan, Arasambattu Kannan
description The objective of this study is to identify the association between linc-ROR genetic variants and oral squamous cell carcinoma tumorigenesis. Four genetic variants of linc-ROR (rs6420545, rs4801078, rs1942348, and rs9636089) were analyzed in 178 OSCCs and 191 controls of the South Indian population by PCR amplification followed by restriction digestion. In addition, we examined whether these variants alter linc-ROR expression levels and the progression of OSCC. The frequency of linc-ROR rs6420545 and rs4801078 genotypes were significantly associated with advanced tumor grade (>2) (p = 0.002 and p = 0.048), and nodal metastasis (p = 0.001 and p = 0.019), respectively. We observed a significant association of rs6420545 specifically in the over-dominant model [OR 1.77 (95%CI; 1.17–2.68); p = 0.006] and rs9636089 in dominant model [OR 2.17 (95%CI; 1.06 – 4.46); p = 0.03], and allelic model [OR 2.26 (95%CI; 1.13 – 4.53) p = 0.02], respectively. Further, significant upregulation of linc-ROR (p = 0.005) was observed in our cohort, consistent with the HNSCC TCGA dataset (p 
doi_str_mv 10.1016/j.archoralbio.2022.105428
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Four genetic variants of linc-ROR (rs6420545, rs4801078, rs1942348, and rs9636089) were analyzed in 178 OSCCs and 191 controls of the South Indian population by PCR amplification followed by restriction digestion. In addition, we examined whether these variants alter linc-ROR expression levels and the progression of OSCC. The frequency of linc-ROR rs6420545 and rs4801078 genotypes were significantly associated with advanced tumor grade (&gt;2) (p = 0.002 and p = 0.048), and nodal metastasis (p = 0.001 and p = 0.019), respectively. We observed a significant association of rs6420545 specifically in the over-dominant model [OR 1.77 (95%CI; 1.17–2.68); p = 0.006] and rs9636089 in dominant model [OR 2.17 (95%CI; 1.06 – 4.46); p = 0.03], and allelic model [OR 2.26 (95%CI; 1.13 – 4.53) p = 0.02], respectively. Further, significant upregulation of linc-ROR (p = 0.005) was observed in our cohort, consistent with the HNSCC TCGA dataset (p &lt; 0.0001). Our findings suggest that the linc-ROR genetic variants could contribute to the metastasis and progression mainly in the late event of tumorigenesis of OSCCs and these variants could be useful in the precision therapeutic management of this cancer particularly in prognosis. •Linc-ROR was significantly overexpressed in our study and HNSCC TCGA dataset.•Variants rs6420545 and rs4801078 associated with late tumorigenic events.•These SNPs are frequent in high grade, and nodal positive tumors.•rs6420545 and rs9636089 showed a significant association in genetic models.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2022.105428</identifier><identifier>PMID: 35461069</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Genetic variants ; Linc-ROR ; Long non-coding RNA ; Oral cancer ; Tobacco</subject><ispartof>Archives of oral biology, 2022-07, Vol.139, p.105428-105428, Article 105428</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. 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Four genetic variants of linc-ROR (rs6420545, rs4801078, rs1942348, and rs9636089) were analyzed in 178 OSCCs and 191 controls of the South Indian population by PCR amplification followed by restriction digestion. In addition, we examined whether these variants alter linc-ROR expression levels and the progression of OSCC. The frequency of linc-ROR rs6420545 and rs4801078 genotypes were significantly associated with advanced tumor grade (&gt;2) (p = 0.002 and p = 0.048), and nodal metastasis (p = 0.001 and p = 0.019), respectively. We observed a significant association of rs6420545 specifically in the over-dominant model [OR 1.77 (95%CI; 1.17–2.68); p = 0.006] and rs9636089 in dominant model [OR 2.17 (95%CI; 1.06 – 4.46); p = 0.03], and allelic model [OR 2.26 (95%CI; 1.13 – 4.53) p = 0.02], respectively. Further, significant upregulation of linc-ROR (p = 0.005) was observed in our cohort, consistent with the HNSCC TCGA dataset (p &lt; 0.0001). Our findings suggest that the linc-ROR genetic variants could contribute to the metastasis and progression mainly in the late event of tumorigenesis of OSCCs and these variants could be useful in the precision therapeutic management of this cancer particularly in prognosis. •Linc-ROR was significantly overexpressed in our study and HNSCC TCGA dataset.•Variants rs6420545 and rs4801078 associated with late tumorigenic events.•These SNPs are frequent in high grade, and nodal positive tumors.•rs6420545 and rs9636089 showed a significant association in genetic models.</description><subject>Genetic variants</subject><subject>Linc-ROR</subject><subject>Long non-coding RNA</subject><subject>Oral cancer</subject><subject>Tobacco</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqNkFtLAzEQhYMotlb_gsQ3X7Ym2Wy2eZTiDQqFos8hl1mbspc22Vb892apio8-hCGHMzNnPoRuKJlSQsXdZqqDXXdB18Z3U0YYS3rB2ewEjemslBktiDhFY0JInkkp5AhdxLhJ30IIeo5GecEFJUKOkVn41mar5Qq_Qwu9t_igg9dtH7EOgHWMnfW6B4c_fL_G_Tpp7qBbmxTnI-gI2Ld4yILjbq-bbh-xhbrGNmX0bdfoS3RW6TrC1XedoLfHh9f5c7ZYPr3M7xeZzUnZZ5SDkaWBklaOA3CbHmFQGDOrylJoRgwHOsuNk44VhctlqXkOueQFM4yzfIJuj3O3odvtIfaq8XGIoltIqRQTAyJC6GCVR6sNXYwBKrUNvtHhU1GiBsRqo_4gVgNidUSceq-_1-xNA-6384dpMsyPBkjHHjwEFa2HgZgPYHvlOv-PNV8QRJOa</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Rose, Mathew Maria</creator><creator>Dhamodharan, Shankar</creator><creator>Bharath, Govindaswamy</creator><creator>Murali, Kannan</creator><creator>Subbiah, Shanmugam</creator><creator>Bhaskar, Lakkakula VKS</creator><creator>Murugan, Avaniyapuram Kannan</creator><creator>Munirajan, Arasambattu Kannan</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202207</creationdate><title>Linc-ROR genetic variants are associated with the advanced disease in oral squamous cell carcinoma</title><author>Rose, Mathew Maria ; Dhamodharan, Shankar ; Bharath, Govindaswamy ; Murali, Kannan ; Subbiah, Shanmugam ; Bhaskar, Lakkakula VKS ; Murugan, Avaniyapuram Kannan ; Munirajan, Arasambattu Kannan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-14eb97be71fd4ee4cee402e5bb8f776a20b4e183bd9d255d397a43e39452b2423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Genetic variants</topic><topic>Linc-ROR</topic><topic>Long non-coding RNA</topic><topic>Oral cancer</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rose, Mathew Maria</creatorcontrib><creatorcontrib>Dhamodharan, Shankar</creatorcontrib><creatorcontrib>Bharath, Govindaswamy</creatorcontrib><creatorcontrib>Murali, Kannan</creatorcontrib><creatorcontrib>Subbiah, Shanmugam</creatorcontrib><creatorcontrib>Bhaskar, Lakkakula VKS</creatorcontrib><creatorcontrib>Murugan, Avaniyapuram Kannan</creatorcontrib><creatorcontrib>Munirajan, Arasambattu Kannan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rose, Mathew Maria</au><au>Dhamodharan, Shankar</au><au>Bharath, Govindaswamy</au><au>Murali, Kannan</au><au>Subbiah, Shanmugam</au><au>Bhaskar, Lakkakula VKS</au><au>Murugan, Avaniyapuram Kannan</au><au>Munirajan, Arasambattu Kannan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linc-ROR genetic variants are associated with the advanced disease in oral squamous cell carcinoma</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2022-07</date><risdate>2022</risdate><volume>139</volume><spage>105428</spage><epage>105428</epage><pages>105428-105428</pages><artnum>105428</artnum><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>The objective of this study is to identify the association between linc-ROR genetic variants and oral squamous cell carcinoma tumorigenesis. 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Our findings suggest that the linc-ROR genetic variants could contribute to the metastasis and progression mainly in the late event of tumorigenesis of OSCCs and these variants could be useful in the precision therapeutic management of this cancer particularly in prognosis. •Linc-ROR was significantly overexpressed in our study and HNSCC TCGA dataset.•Variants rs6420545 and rs4801078 associated with late tumorigenic events.•These SNPs are frequent in high grade, and nodal positive tumors.•rs6420545 and rs9636089 showed a significant association in genetic models.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35461069</pmid><doi>10.1016/j.archoralbio.2022.105428</doi><tpages>1</tpages></addata></record>
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subjects Genetic variants
Linc-ROR
Long non-coding RNA
Oral cancer
Tobacco
title Linc-ROR genetic variants are associated with the advanced disease in oral squamous cell carcinoma
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