SIRT1 regulates trophoblast senescence in premature placental aging in preeclampsia

Premature placental aging is implicated in a number of complications of pregnancy including preeclampsia. A placenta knockout mouse model has shown a relationship between SIRT1, aging and placental dysfunction. The role of SIRT1 in cellular senescence has been extensively studied in various cell typ...

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Veröffentlicht in:	Placenta (Eastbourne) 2022-05, Vol.122, p.56-65
Hauptverfasser:	Wang, YuJia, Zhang, Yingye, Wu, Yongqi, He, Yunbiao, Xiang, Jingwen, Huang, Jieqiong, Lash, Gendie E., Li, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging, Premature - metabolism Animals Cellular Senescence Female Humans Mice Placenta Placenta - metabolism Pre-Eclampsia - metabolism Preeclampsia Pregnancy Sirtuin 1 - metabolism Syncytiotrophoblast Trophoblasts - metabolism
Online-Zugang:	Volltext
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