Multicentric Castlemans disease. Symptoms, diagnostics and therapy
Castleman disease (CD) describes a group of heterogeneous hematologic disorders with characteristic histopathological features. CD can present with unicentric (UCD) or multicentric (MCD) regions of lymph node enlargement. Some cases of MCD are caused by human herpesvirus-8 (HHV-8), whereas others ar...
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| Veröffentlicht in: | Vnitřní lékar̆stvĭ 2022, Vol.68 (1), p.41-53 |
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| container_title | Vnitřní lékar̆stvĭ |
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| creator | Adam, Zdeněk Řehák, Zdeněk Adamová, Zuzana Koukalová, Renata Pour, Luděk Krejčí, Marta Boichuk, Ivanna Sandecká, Viera Krejčí, Martin Štork, Martin Ševčíková, Sabina Král, Zdeněk |
| description | Castleman disease (CD) describes a group of heterogeneous hematologic disorders with characteristic histopathological features. CD can present with unicentric (UCD) or multicentric (MCD) regions of lymph node enlargement. Some cases of MCD are caused by human herpesvirus-8 (HHV-8), whereas others are HHV-8-negative/idiopathic (iMCD). Treatment of iMCD is challenging, and outcomes can be poor. In this paper, we briefly report about symptoms of iMCD and about the International, evidencebased consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease and International evidence based consensus treatment guidelines for idiopathic multicentric Castleman disease. |
| doi_str_mv | 10.36290/vnl.2022.006 |
| format | Article |
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Treatment of iMCD is challenging, and outcomes can be poor. 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| language | cze ; eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Castleman Disease - diagnosis Castleman Disease - pathology Castleman Disease - therapy Consensus Herpesvirus 8, Human Humans |
| title | Multicentric Castlemans disease. Symptoms, diagnostics and therapy |
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