Prognostic Significance of Intraoperative Peritoneal Lavage Cytology in Patients with Pancreatic Ductal Adenocarcinoma: A Single-Center Experience and Systematic Review of the Literature
Background The prognostic significance of peritoneal lavage cytology (PLC) in patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. The purpose of this study was to evaluate the prognostic impact of PLC status in PDAC patients. Methods Patients intending to undergo resection f...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 2022-09, Vol.29 (9), p.5972-5983 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5983 |
|---|---|
| container_issue | 9 |
| container_start_page | 5972 |
| container_title | Annals of surgical oncology |
| container_volume | 29 |
| creator | Kawakatsu, Shoji Shimizu, Yasuhiro Natsume, Seiji Okuno, Masataka Ito, Seiji Komori, Koji Abe, Tetsuya Misawa, Kazunari Ito, Yuichi Kinoshita, Takashi Higaki, Eiji Fujieda, Hironori Sato, Yusuke Ouchi, Akira Nagino, Masato Hara, Kazuo Matsuo, Keitaro Hosoda, Waki |
| description | Background
The prognostic significance of peritoneal lavage cytology (PLC) in patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. The purpose of this study was to evaluate the prognostic impact of PLC status in PDAC patients.
Methods
Patients intending to undergo resection for PDAC between 2007 and 2020 were included. Survival was compared among patients who underwent resection with negative or positive PLC status and those who did not undergo resection. Univariable and multivariable analyses were conducted to evaluate the prognostic impact of positive PLC status. A systematic literature review was performed to evaluate the correlation between prognosis and the positive PLC rate.
Results
A total of 480 patients formed the study cohort and were divided as follows: 438 in the negative PLC group, 18 in the positive PLC group, and 24 in the no resection group. Although the median survival time significantly differed between the negative and positive PLC groups (35.7 vs. 13.6 months,
P
< 0.001), it did not significantly differ between the positive PLC and no resection groups (13.6 vs. 12.2 months,
P
= 0.605). Multivariable analyses demonstrated that positive PLC status (hazard ratio = 3.54, 95% confidence interval = 1.97–6.38,
P
< 0.001) was the strongest poor prognostic factor. Based on statistical analyses for the systematic review, the prognostic impact of positive PLC status weakened significantly as the institutional positive PLC rate increased (
P
= 0.044).
Conclusions
Resection did not improve the prognosis of patients with positive PLC status in our cohort. The institutional positive PLC rate may be a good reference for surgical indication in these patients. |
| doi_str_mv | 10.1245/s10434-022-11722-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2653269842</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2653269842</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-ad4615f5e0497ba6aff5b264447676663ec442dca2bc4d05437f0d74ac48e543</originalsourceid><addsrcrecordid>eNp9kcFuEzEQhlcIREvhBTggS1y4LNjesTfLLQoFKkUior2vHO_s1tXGDrY3TV6Np2PSFJA4cLE99vf_M_JfFK8Ffy8kqA9JcKig5FKWQtS07p8U50LRFeiZeEpnrmdlI7U6K16kdMe5qCuunhdnlQJQDRfnxc9VDIMPKTvLrt3gXe-s8RZZ6NmVz9GELUaT3Q7ZCqPLwaMZ2dLszIBscchhDMOBOc9WBKHPid27fEuVtxHN0fXTZDNJ5h36YE20zoeN-cjm1M4PI5YLUmFkl3tqRA7U2viOXR9Sxs2DwXfcObw_DpRvkS1dPg40RXxZPOvNmPDV435R3Hy-vFl8LZffvlwt5svSVrXKpelAC9Ur5NDUa6NN36u11ABQ61prXaEFkJ01cm2h4wqquuddDcbCDKm6KN6dbLcx_Jgw5XbjksVxNB7DlFr63krqZgaS0Lf_oHdhip6GI6pppKygVkTJE2VjSCli326j25h4aAVvj8G2p2BbCrZ9CLbdk-jNo_W03mD3R_I7SQKqE5DoyQ8Y__b-j-0v4TWyGg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2699223475</pqid></control><display><type>article</type><title>Prognostic Significance of Intraoperative Peritoneal Lavage Cytology in Patients with Pancreatic Ductal Adenocarcinoma: A Single-Center Experience and Systematic Review of the Literature</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kawakatsu, Shoji ; Shimizu, Yasuhiro ; Natsume, Seiji ; Okuno, Masataka ; Ito, Seiji ; Komori, Koji ; Abe, Tetsuya ; Misawa, Kazunari ; Ito, Yuichi ; Kinoshita, Takashi ; Higaki, Eiji ; Fujieda, Hironori ; Sato, Yusuke ; Ouchi, Akira ; Nagino, Masato ; Hara, Kazuo ; Matsuo, Keitaro ; Hosoda, Waki</creator><creatorcontrib>Kawakatsu, Shoji ; Shimizu, Yasuhiro ; Natsume, Seiji ; Okuno, Masataka ; Ito, Seiji ; Komori, Koji ; Abe, Tetsuya ; Misawa, Kazunari ; Ito, Yuichi ; Kinoshita, Takashi ; Higaki, Eiji ; Fujieda, Hironori ; Sato, Yusuke ; Ouchi, Akira ; Nagino, Masato ; Hara, Kazuo ; Matsuo, Keitaro ; Hosoda, Waki</creatorcontrib><description>Background
The prognostic significance of peritoneal lavage cytology (PLC) in patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. The purpose of this study was to evaluate the prognostic impact of PLC status in PDAC patients.
Methods
Patients intending to undergo resection for PDAC between 2007 and 2020 were included. Survival was compared among patients who underwent resection with negative or positive PLC status and those who did not undergo resection. Univariable and multivariable analyses were conducted to evaluate the prognostic impact of positive PLC status. A systematic literature review was performed to evaluate the correlation between prognosis and the positive PLC rate.
Results
A total of 480 patients formed the study cohort and were divided as follows: 438 in the negative PLC group, 18 in the positive PLC group, and 24 in the no resection group. Although the median survival time significantly differed between the negative and positive PLC groups (35.7 vs. 13.6 months,
P
< 0.001), it did not significantly differ between the positive PLC and no resection groups (13.6 vs. 12.2 months,
P
= 0.605). Multivariable analyses demonstrated that positive PLC status (hazard ratio = 3.54, 95% confidence interval = 1.97–6.38,
P
< 0.001) was the strongest poor prognostic factor. Based on statistical analyses for the systematic review, the prognostic impact of positive PLC status weakened significantly as the institutional positive PLC rate increased (
P
= 0.044).
Conclusions
Resection did not improve the prognosis of patients with positive PLC status in our cohort. The institutional positive PLC rate may be a good reference for surgical indication in these patients.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-022-11722-x</identifier><identifier>PMID: 35445901</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adenocarcinoma ; Cancer ; Carcinoma, Pancreatic Ductal - pathology ; Cellular biology ; Cytology ; Humans ; Literature reviews ; Lung Neoplasms - pathology ; Medical prognosis ; Medicine ; Medicine & Public Health ; Neoplasm Staging ; Oncology ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms ; Pancreatic Neoplasms - pathology ; Pancreatic Tumors ; Peritoneal Lavage ; Peritoneum ; Prognosis ; Retrospective Studies ; Statistical analysis ; Surgery ; Surgical Oncology ; Survival ; Systematic review</subject><ispartof>Annals of surgical oncology, 2022-09, Vol.29 (9), p.5972-5983</ispartof><rights>Society of Surgical Oncology 2022</rights><rights>2022. Society of Surgical Oncology.</rights><rights>Society of Surgical Oncology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ad4615f5e0497ba6aff5b264447676663ec442dca2bc4d05437f0d74ac48e543</citedby><cites>FETCH-LOGICAL-c375t-ad4615f5e0497ba6aff5b264447676663ec442dca2bc4d05437f0d74ac48e543</cites><orcidid>0000-0002-6692-552X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-022-11722-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-022-11722-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35445901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakatsu, Shoji</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><creatorcontrib>Natsume, Seiji</creatorcontrib><creatorcontrib>Okuno, Masataka</creatorcontrib><creatorcontrib>Ito, Seiji</creatorcontrib><creatorcontrib>Komori, Koji</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Misawa, Kazunari</creatorcontrib><creatorcontrib>Ito, Yuichi</creatorcontrib><creatorcontrib>Kinoshita, Takashi</creatorcontrib><creatorcontrib>Higaki, Eiji</creatorcontrib><creatorcontrib>Fujieda, Hironori</creatorcontrib><creatorcontrib>Sato, Yusuke</creatorcontrib><creatorcontrib>Ouchi, Akira</creatorcontrib><creatorcontrib>Nagino, Masato</creatorcontrib><creatorcontrib>Hara, Kazuo</creatorcontrib><creatorcontrib>Matsuo, Keitaro</creatorcontrib><creatorcontrib>Hosoda, Waki</creatorcontrib><title>Prognostic Significance of Intraoperative Peritoneal Lavage Cytology in Patients with Pancreatic Ductal Adenocarcinoma: A Single-Center Experience and Systematic Review of the Literature</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
The prognostic significance of peritoneal lavage cytology (PLC) in patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. The purpose of this study was to evaluate the prognostic impact of PLC status in PDAC patients.
Methods
Patients intending to undergo resection for PDAC between 2007 and 2020 were included. Survival was compared among patients who underwent resection with negative or positive PLC status and those who did not undergo resection. Univariable and multivariable analyses were conducted to evaluate the prognostic impact of positive PLC status. A systematic literature review was performed to evaluate the correlation between prognosis and the positive PLC rate.
Results
A total of 480 patients formed the study cohort and were divided as follows: 438 in the negative PLC group, 18 in the positive PLC group, and 24 in the no resection group. Although the median survival time significantly differed between the negative and positive PLC groups (35.7 vs. 13.6 months,
P
< 0.001), it did not significantly differ between the positive PLC and no resection groups (13.6 vs. 12.2 months,
P
= 0.605). Multivariable analyses demonstrated that positive PLC status (hazard ratio = 3.54, 95% confidence interval = 1.97–6.38,
P
< 0.001) was the strongest poor prognostic factor. Based on statistical analyses for the systematic review, the prognostic impact of positive PLC status weakened significantly as the institutional positive PLC rate increased (
P
= 0.044).
Conclusions
Resection did not improve the prognosis of patients with positive PLC status in our cohort. The institutional positive PLC rate may be a good reference for surgical indication in these patients.</description><subject>Adenocarcinoma</subject><subject>Cancer</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Cellular biology</subject><subject>Cytology</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Tumors</subject><subject>Peritoneal Lavage</subject><subject>Peritoneum</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Systematic review</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcFuEzEQhlcIREvhBTggS1y4LNjesTfLLQoFKkUior2vHO_s1tXGDrY3TV6Np2PSFJA4cLE99vf_M_JfFK8Ffy8kqA9JcKig5FKWQtS07p8U50LRFeiZeEpnrmdlI7U6K16kdMe5qCuunhdnlQJQDRfnxc9VDIMPKTvLrt3gXe-s8RZZ6NmVz9GELUaT3Q7ZCqPLwaMZ2dLszIBscchhDMOBOc9WBKHPid27fEuVtxHN0fXTZDNJ5h36YE20zoeN-cjm1M4PI5YLUmFkl3tqRA7U2viOXR9Sxs2DwXfcObw_DpRvkS1dPg40RXxZPOvNmPDV435R3Hy-vFl8LZffvlwt5svSVrXKpelAC9Ur5NDUa6NN36u11ABQ61prXaEFkJ01cm2h4wqquuddDcbCDKm6KN6dbLcx_Jgw5XbjksVxNB7DlFr63krqZgaS0Lf_oHdhip6GI6pppKygVkTJE2VjSCli326j25h4aAVvj8G2p2BbCrZ9CLbdk-jNo_W03mD3R_I7SQKqE5DoyQ8Y__b-j-0v4TWyGg</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Kawakatsu, Shoji</creator><creator>Shimizu, Yasuhiro</creator><creator>Natsume, Seiji</creator><creator>Okuno, Masataka</creator><creator>Ito, Seiji</creator><creator>Komori, Koji</creator><creator>Abe, Tetsuya</creator><creator>Misawa, Kazunari</creator><creator>Ito, Yuichi</creator><creator>Kinoshita, Takashi</creator><creator>Higaki, Eiji</creator><creator>Fujieda, Hironori</creator><creator>Sato, Yusuke</creator><creator>Ouchi, Akira</creator><creator>Nagino, Masato</creator><creator>Hara, Kazuo</creator><creator>Matsuo, Keitaro</creator><creator>Hosoda, Waki</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6692-552X</orcidid></search><sort><creationdate>20220901</creationdate><title>Prognostic Significance of Intraoperative Peritoneal Lavage Cytology in Patients with Pancreatic Ductal Adenocarcinoma: A Single-Center Experience and Systematic Review of the Literature</title><author>Kawakatsu, Shoji ; Shimizu, Yasuhiro ; Natsume, Seiji ; Okuno, Masataka ; Ito, Seiji ; Komori, Koji ; Abe, Tetsuya ; Misawa, Kazunari ; Ito, Yuichi ; Kinoshita, Takashi ; Higaki, Eiji ; Fujieda, Hironori ; Sato, Yusuke ; Ouchi, Akira ; Nagino, Masato ; Hara, Kazuo ; Matsuo, Keitaro ; Hosoda, Waki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ad4615f5e0497ba6aff5b264447676663ec442dca2bc4d05437f0d74ac48e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Cancer</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Cellular biology</topic><topic>Cytology</topic><topic>Humans</topic><topic>Literature reviews</topic><topic>Lung Neoplasms - pathology</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Tumors</topic><topic>Peritoneal Lavage</topic><topic>Peritoneum</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakatsu, Shoji</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><creatorcontrib>Natsume, Seiji</creatorcontrib><creatorcontrib>Okuno, Masataka</creatorcontrib><creatorcontrib>Ito, Seiji</creatorcontrib><creatorcontrib>Komori, Koji</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Misawa, Kazunari</creatorcontrib><creatorcontrib>Ito, Yuichi</creatorcontrib><creatorcontrib>Kinoshita, Takashi</creatorcontrib><creatorcontrib>Higaki, Eiji</creatorcontrib><creatorcontrib>Fujieda, Hironori</creatorcontrib><creatorcontrib>Sato, Yusuke</creatorcontrib><creatorcontrib>Ouchi, Akira</creatorcontrib><creatorcontrib>Nagino, Masato</creatorcontrib><creatorcontrib>Hara, Kazuo</creatorcontrib><creatorcontrib>Matsuo, Keitaro</creatorcontrib><creatorcontrib>Hosoda, Waki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakatsu, Shoji</au><au>Shimizu, Yasuhiro</au><au>Natsume, Seiji</au><au>Okuno, Masataka</au><au>Ito, Seiji</au><au>Komori, Koji</au><au>Abe, Tetsuya</au><au>Misawa, Kazunari</au><au>Ito, Yuichi</au><au>Kinoshita, Takashi</au><au>Higaki, Eiji</au><au>Fujieda, Hironori</au><au>Sato, Yusuke</au><au>Ouchi, Akira</au><au>Nagino, Masato</au><au>Hara, Kazuo</au><au>Matsuo, Keitaro</au><au>Hosoda, Waki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Intraoperative Peritoneal Lavage Cytology in Patients with Pancreatic Ductal Adenocarcinoma: A Single-Center Experience and Systematic Review of the Literature</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>29</volume><issue>9</issue><spage>5972</spage><epage>5983</epage><pages>5972-5983</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
The prognostic significance of peritoneal lavage cytology (PLC) in patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. The purpose of this study was to evaluate the prognostic impact of PLC status in PDAC patients.
Methods
Patients intending to undergo resection for PDAC between 2007 and 2020 were included. Survival was compared among patients who underwent resection with negative or positive PLC status and those who did not undergo resection. Univariable and multivariable analyses were conducted to evaluate the prognostic impact of positive PLC status. A systematic literature review was performed to evaluate the correlation between prognosis and the positive PLC rate.
Results
A total of 480 patients formed the study cohort and were divided as follows: 438 in the negative PLC group, 18 in the positive PLC group, and 24 in the no resection group. Although the median survival time significantly differed between the negative and positive PLC groups (35.7 vs. 13.6 months,
P
< 0.001), it did not significantly differ between the positive PLC and no resection groups (13.6 vs. 12.2 months,
P
= 0.605). Multivariable analyses demonstrated that positive PLC status (hazard ratio = 3.54, 95% confidence interval = 1.97–6.38,
P
< 0.001) was the strongest poor prognostic factor. Based on statistical analyses for the systematic review, the prognostic impact of positive PLC status weakened significantly as the institutional positive PLC rate increased (
P
= 0.044).
Conclusions
Resection did not improve the prognosis of patients with positive PLC status in our cohort. The institutional positive PLC rate may be a good reference for surgical indication in these patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35445901</pmid><doi>10.1245/s10434-022-11722-x</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6692-552X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2022-09, Vol.29 (9), p.5972-5983 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2653269842 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adenocarcinoma Cancer Carcinoma, Pancreatic Ductal - pathology Cellular biology Cytology Humans Literature reviews Lung Neoplasms - pathology Medical prognosis Medicine Medicine & Public Health Neoplasm Staging Oncology Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - pathology Pancreatic Tumors Peritoneal Lavage Peritoneum Prognosis Retrospective Studies Statistical analysis Surgery Surgical Oncology Survival Systematic review |
| title | Prognostic Significance of Intraoperative Peritoneal Lavage Cytology in Patients with Pancreatic Ductal Adenocarcinoma: A Single-Center Experience and Systematic Review of the Literature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T01%3A45%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Significance%20of%20Intraoperative%20Peritoneal%20Lavage%20Cytology%20in%20Patients%20with%20Pancreatic%20Ductal%20Adenocarcinoma:%20A%20Single-Center%20Experience%20and%20Systematic%20Review%20of%20the%20Literature&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Kawakatsu,%20Shoji&rft.date=2022-09-01&rft.volume=29&rft.issue=9&rft.spage=5972&rft.epage=5983&rft.pages=5972-5983&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-022-11722-x&rft_dat=%3Cproquest_cross%3E2653269842%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2699223475&rft_id=info:pmid/35445901&rfr_iscdi=true |