ATG4A regulates human erythroid maturation and mitochondrial clearance

Autophagy is a self-degradation pathway that is essential for erythropoiesis. During erythroid differentiation, autophagy facilitates the degradation of macromolecules and the programmed clearance of mitochondria. Impaired mitochondrial clearance results in anemia and alters the lifespan of red bloo...

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Veröffentlicht in:	Blood advances 2022-06, Vol.6 (12), p.3579-3589
Hauptverfasser:	Stolla, Massiel Chavez, Reilly, Andreea, Bergantinos, Rochelle, Stewart, Sintra, Thom, Neele, Clough, Courtnee A., Wellington, Rachel C., Stolitenko, Raisa, Abkowitz, Janis L., Doulatov, Sergei
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - genetics Autophagy-Related Proteins - metabolism Cell Differentiation Cysteine Endopeptidases - metabolism Erythropoiesis - genetics Humans Mitochondria - metabolism Reticulocytes - metabolism
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