The potential efficacy and mechanism of bendamustine in entra‐nodal NK/T cell lymphoma

Bendamustine has been shown to have anti‐tumor activities in hematological malignancies, but the role of bendamustine in natural killer (NK)/T cell lymphoma (NKTCL) treatment is unclear. Our study has shown that bendamustine had potent growth‐inhibitory and apoptosis‐inducing effects on NKTCL cells....

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Veröffentlicht in:	Hematological oncology 2022-10, Vol.40 (4), p.678-688
Hauptverfasser:	Gao, Yuyang, Feng, Xiaoyan, Song, Wenting, Li, Hongwen, Shi, Cunzhen, Jin, Mengyuan, Li, Zhaoming, Zhang, Lei, Zhang, Mingzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Ataxia Ataxia telangiectasia Ataxia telangiectasia mutated protein bendamustine Biocompatibility Cdc2 protein Cell cycle cell cycle arrest Cell proliferation CHK1 protein CHK2 protein Cyclin B1 Cytotoxicity DNA damage DNA damage response Etoposide Gemcitabine Lymphocytes Lymphocytes T Lymphoma Mitochondria Natural killer cells NK/T‐cell lymphoma p53 Protein Phosphorylation Poly(ADP-ribose) polymerase Reactive oxygen species Ribose Stat3 protein T-cell lymphoma Toxicity Tumors
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