Assessment of brain tumors by magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging and computed tomography perfusion: a comparison study
Purpose To investigate the association and agreement between magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) and computed tomography perfusion (CTP) in determining vascularity and permeability of primary and secondary brain tumors. Material and methods DSC-PWI...
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| Veröffentlicht in: | Radiologia medica 2022-06, Vol.127 (6), p.664-672 |
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| container_title | Radiologia medica |
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| creator | Scola, Elisa Desideri, Ilaria Bianchi, Andrea Gadda, Davide Busto, Giorgio Fiorenza, Alessandro Amadori, Tommaso Mancini, Sara Miele, Vittorio Fainardi, Enrico |
| description | Purpose
To investigate the association and agreement between magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) and computed tomography perfusion (CTP) in determining vascularity and permeability of primary and secondary brain tumors.
Material and methods
DSC-PWI and CTP studies from 97 patients with high-grade glioma, low-grade glioma and solitary brain metastasis were retrospectively reviewed. Normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), capillary transfer constant (nK2) and permeability surface area product (nPS) values were obtained. Variables among groups were compared, and correlation and agreement between DSC-PWI and CTP were tested.
Results
All DSC-PWI and CTP parameters were higher in high-grade than in low-grade gliomas (
p
|
| doi_str_mv | 10.1007/s11547-022-01470-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2652863352</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2652863352</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-ff3870fd0bd75441078d4660987eb25faa77f469b32c2fe05a94e680192098b43</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS1ERUvhBVggS2zYhI5_Esfsqqr8SJW6gXXkJHbq6sYOHkcofRveFN_eQhGLrmyNv3NmxoeQNww-MAB1hozVUlXAeQVMKqjunpET1vKmanQrnv9zPyYvEW8BJDDQL8ixqKVkWsEJ-XWOaBFnGzKNjvbJ-EDzOseEtN_obKZgsx9oshiDCYOl4xbMXCq44mCX7Hu_83mjQww5Gcx0scmt6GOoflo_3WQ7Ul9sfJioCWPh5mXdF3Oc45TMcrM9Sj5Scw-Y5Es7inkdt1fkyJkd2tcP5yn5_uny28WX6ur689eL86tqEKrOlXOiVeBG6Ee13w5UO8qmAd0q2_PaGaOUk43uBR-4s1AbLW3TAtO8ML0Up-T9wXdJ8cdqMXezLxvudibYuGLHm5q3jRA1L-i7_9DbuKZQpitUo0FIrnSh-IEaUkRM1nVLKj-Rto5Btw-wOwTYlQC7-wC7uyJ6-2C99rMd_0r-JFYAcQCwPIXJpsfeT9j-BtPpqss</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2669034279</pqid></control><display><type>article</type><title>Assessment of brain tumors by magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging and computed tomography perfusion: a comparison study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Scola, Elisa ; Desideri, Ilaria ; Bianchi, Andrea ; Gadda, Davide ; Busto, Giorgio ; Fiorenza, Alessandro ; Amadori, Tommaso ; Mancini, Sara ; Miele, Vittorio ; Fainardi, Enrico</creator><creatorcontrib>Scola, Elisa ; Desideri, Ilaria ; Bianchi, Andrea ; Gadda, Davide ; Busto, Giorgio ; Fiorenza, Alessandro ; Amadori, Tommaso ; Mancini, Sara ; Miele, Vittorio ; Fainardi, Enrico</creatorcontrib><description><![CDATA[Purpose
To investigate the association and agreement between magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) and computed tomography perfusion (CTP) in determining vascularity and permeability of primary and secondary brain tumors.
Material and methods
DSC-PWI and CTP studies from 97 patients with high-grade glioma, low-grade glioma and solitary brain metastasis were retrospectively reviewed. Normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), capillary transfer constant (nK2) and permeability surface area product (nPS) values were obtained. Variables among groups were compared, and correlation and agreement between DSC-PWI and CTP were tested.
Results
All DSC-PWI and CTP parameters were higher in high-grade than in low-grade gliomas (
p
< 0.01 and
p
< 0.001). Metastases had greater DSC-PWI nCBV (
p
< 0.05), nCTP-CBF (
p
< 0.05), nCTP-CBV (
p
< 0.01) and nCTP-PS (
p
< 0.0001) than low-grade gliomas and more elevated nCTP-PS (
p
< 0.01) than high-grade gliomas. The correlation was strong between DSC-PWI nCBF and CTP nCBF (
r
= 0.79;
p
< 0.00001) and between DSC-PWI nCBV and CTP nCBV (
r
= 0.83;
p
< 0.00001), weaker between DSC-PWI nK2 and CTP nPS (
r
= 0.29;
p
< 0.01). Bland–Altman plots indicated that the agreement was strong between DSC-PWI nCBF and CTP nCBF, good between DSC-PWI nCBV and CTP nCBV and poorer between DSC-PWI nK2 and CTP nPS.
Conclusion
DSC-PWI and CTP CBF and CBV maps were comparable and interchangeable in the assessment of tumor vascularity, unlike DSC-PWI K2 and CTP PS maps that were more discordant in the analysis of tumor permeability. CTP could be an alternative method to quantify tumor neoangiogenesis when MRI is not available or when the patient does not tolerate it.]]></description><identifier>ISSN: 1826-6983</identifier><identifier>ISSN: 0033-8362</identifier><identifier>EISSN: 1826-6983</identifier><identifier>DOI: 10.1007/s11547-022-01470-z</identifier><identifier>PMID: 35441970</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Blood flow ; Blood volume ; Brain ; Brain cancer ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - pathology ; Cerebrovascular Circulation - physiology ; Computed tomography ; Contrast Media ; Diagnostic Radiology ; Glioma - diagnostic imaging ; Glioma - pathology ; Humans ; Imaging ; Interventional Radiology ; Magnetic resonance ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy ; Medical imaging ; Medicine ; Medicine & Public Health ; Neuroradiology ; Perfusion ; Permeability ; Radiology ; Retrospective Studies ; Tomography ; Tumors ; Ultrasound</subject><ispartof>Radiologia medica, 2022-06, Vol.127 (6), p.664-672</ispartof><rights>Italian Society of Medical Radiology 2022</rights><rights>2022. Italian Society of Medical Radiology.</rights><rights>Italian Society of Medical Radiology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ff3870fd0bd75441078d4660987eb25faa77f469b32c2fe05a94e680192098b43</citedby><cites>FETCH-LOGICAL-c375t-ff3870fd0bd75441078d4660987eb25faa77f469b32c2fe05a94e680192098b43</cites><orcidid>0000-0001-9056-4122</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11547-022-01470-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11547-022-01470-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35441970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scola, Elisa</creatorcontrib><creatorcontrib>Desideri, Ilaria</creatorcontrib><creatorcontrib>Bianchi, Andrea</creatorcontrib><creatorcontrib>Gadda, Davide</creatorcontrib><creatorcontrib>Busto, Giorgio</creatorcontrib><creatorcontrib>Fiorenza, Alessandro</creatorcontrib><creatorcontrib>Amadori, Tommaso</creatorcontrib><creatorcontrib>Mancini, Sara</creatorcontrib><creatorcontrib>Miele, Vittorio</creatorcontrib><creatorcontrib>Fainardi, Enrico</creatorcontrib><title>Assessment of brain tumors by magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging and computed tomography perfusion: a comparison study</title><title>Radiologia medica</title><addtitle>Radiol med</addtitle><addtitle>Radiol Med</addtitle><description><![CDATA[Purpose
To investigate the association and agreement between magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) and computed tomography perfusion (CTP) in determining vascularity and permeability of primary and secondary brain tumors.
Material and methods
DSC-PWI and CTP studies from 97 patients with high-grade glioma, low-grade glioma and solitary brain metastasis were retrospectively reviewed. Normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), capillary transfer constant (nK2) and permeability surface area product (nPS) values were obtained. Variables among groups were compared, and correlation and agreement between DSC-PWI and CTP were tested.
Results
All DSC-PWI and CTP parameters were higher in high-grade than in low-grade gliomas (
p
< 0.01 and
p
< 0.001). Metastases had greater DSC-PWI nCBV (
p
< 0.05), nCTP-CBF (
p
< 0.05), nCTP-CBV (
p
< 0.01) and nCTP-PS (
p
< 0.0001) than low-grade gliomas and more elevated nCTP-PS (
p
< 0.01) than high-grade gliomas. The correlation was strong between DSC-PWI nCBF and CTP nCBF (
r
= 0.79;
p
< 0.00001) and between DSC-PWI nCBV and CTP nCBV (
r
= 0.83;
p
< 0.00001), weaker between DSC-PWI nK2 and CTP nPS (
r
= 0.29;
p
< 0.01). Bland–Altman plots indicated that the agreement was strong between DSC-PWI nCBF and CTP nCBF, good between DSC-PWI nCBV and CTP nCBV and poorer between DSC-PWI nK2 and CTP nPS.
Conclusion
DSC-PWI and CTP CBF and CBV maps were comparable and interchangeable in the assessment of tumor vascularity, unlike DSC-PWI K2 and CTP PS maps that were more discordant in the analysis of tumor permeability. CTP could be an alternative method to quantify tumor neoangiogenesis when MRI is not available or when the patient does not tolerate it.]]></description><subject>Blood flow</subject><subject>Blood volume</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - pathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Computed tomography</subject><subject>Contrast Media</subject><subject>Diagnostic Radiology</subject><subject>Glioma - diagnostic imaging</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Perfusion</subject><subject>Permeability</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Ultrasound</subject><issn>1826-6983</issn><issn>0033-8362</issn><issn>1826-6983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS1ERUvhBVggS2zYhI5_Esfsqqr8SJW6gXXkJHbq6sYOHkcofRveFN_eQhGLrmyNv3NmxoeQNww-MAB1hozVUlXAeQVMKqjunpET1vKmanQrnv9zPyYvEW8BJDDQL8ixqKVkWsEJ-XWOaBFnGzKNjvbJ-EDzOseEtN_obKZgsx9oshiDCYOl4xbMXCq44mCX7Hu_83mjQww5Gcx0scmt6GOoflo_3WQ7Ul9sfJioCWPh5mXdF3Oc45TMcrM9Sj5Scw-Y5Es7inkdt1fkyJkd2tcP5yn5_uny28WX6ur689eL86tqEKrOlXOiVeBG6Ee13w5UO8qmAd0q2_PaGaOUk43uBR-4s1AbLW3TAtO8ML0Up-T9wXdJ8cdqMXezLxvudibYuGLHm5q3jRA1L-i7_9DbuKZQpitUo0FIrnSh-IEaUkRM1nVLKj-Rto5Btw-wOwTYlQC7-wC7uyJ6-2C99rMd_0r-JFYAcQCwPIXJpsfeT9j-BtPpqss</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Scola, Elisa</creator><creator>Desideri, Ilaria</creator><creator>Bianchi, Andrea</creator><creator>Gadda, Davide</creator><creator>Busto, Giorgio</creator><creator>Fiorenza, Alessandro</creator><creator>Amadori, Tommaso</creator><creator>Mancini, Sara</creator><creator>Miele, Vittorio</creator><creator>Fainardi, Enrico</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9056-4122</orcidid></search><sort><creationdate>20220601</creationdate><title>Assessment of brain tumors by magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging and computed tomography perfusion: a comparison study</title><author>Scola, Elisa ; Desideri, Ilaria ; Bianchi, Andrea ; Gadda, Davide ; Busto, Giorgio ; Fiorenza, Alessandro ; Amadori, Tommaso ; Mancini, Sara ; Miele, Vittorio ; Fainardi, Enrico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ff3870fd0bd75441078d4660987eb25faa77f469b32c2fe05a94e680192098b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Blood flow</topic><topic>Blood volume</topic><topic>Brain</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - pathology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Computed tomography</topic><topic>Contrast Media</topic><topic>Diagnostic Radiology</topic><topic>Glioma - diagnostic imaging</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Perfusion</topic><topic>Permeability</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scola, Elisa</creatorcontrib><creatorcontrib>Desideri, Ilaria</creatorcontrib><creatorcontrib>Bianchi, Andrea</creatorcontrib><creatorcontrib>Gadda, Davide</creatorcontrib><creatorcontrib>Busto, Giorgio</creatorcontrib><creatorcontrib>Fiorenza, Alessandro</creatorcontrib><creatorcontrib>Amadori, Tommaso</creatorcontrib><creatorcontrib>Mancini, Sara</creatorcontrib><creatorcontrib>Miele, Vittorio</creatorcontrib><creatorcontrib>Fainardi, Enrico</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiologia medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scola, Elisa</au><au>Desideri, Ilaria</au><au>Bianchi, Andrea</au><au>Gadda, Davide</au><au>Busto, Giorgio</au><au>Fiorenza, Alessandro</au><au>Amadori, Tommaso</au><au>Mancini, Sara</au><au>Miele, Vittorio</au><au>Fainardi, Enrico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of brain tumors by magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging and computed tomography perfusion: a comparison study</atitle><jtitle>Radiologia medica</jtitle><stitle>Radiol med</stitle><addtitle>Radiol Med</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>127</volume><issue>6</issue><spage>664</spage><epage>672</epage><pages>664-672</pages><issn>1826-6983</issn><issn>0033-8362</issn><eissn>1826-6983</eissn><abstract><![CDATA[Purpose
To investigate the association and agreement between magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) and computed tomography perfusion (CTP) in determining vascularity and permeability of primary and secondary brain tumors.
Material and methods
DSC-PWI and CTP studies from 97 patients with high-grade glioma, low-grade glioma and solitary brain metastasis were retrospectively reviewed. Normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), capillary transfer constant (nK2) and permeability surface area product (nPS) values were obtained. Variables among groups were compared, and correlation and agreement between DSC-PWI and CTP were tested.
Results
All DSC-PWI and CTP parameters were higher in high-grade than in low-grade gliomas (
p
< 0.01 and
p
< 0.001). Metastases had greater DSC-PWI nCBV (
p
< 0.05), nCTP-CBF (
p
< 0.05), nCTP-CBV (
p
< 0.01) and nCTP-PS (
p
< 0.0001) than low-grade gliomas and more elevated nCTP-PS (
p
< 0.01) than high-grade gliomas. The correlation was strong between DSC-PWI nCBF and CTP nCBF (
r
= 0.79;
p
< 0.00001) and between DSC-PWI nCBV and CTP nCBV (
r
= 0.83;
p
< 0.00001), weaker between DSC-PWI nK2 and CTP nPS (
r
= 0.29;
p
< 0.01). Bland–Altman plots indicated that the agreement was strong between DSC-PWI nCBF and CTP nCBF, good between DSC-PWI nCBV and CTP nCBV and poorer between DSC-PWI nK2 and CTP nPS.
Conclusion
DSC-PWI and CTP CBF and CBV maps were comparable and interchangeable in the assessment of tumor vascularity, unlike DSC-PWI K2 and CTP PS maps that were more discordant in the analysis of tumor permeability. CTP could be an alternative method to quantify tumor neoangiogenesis when MRI is not available or when the patient does not tolerate it.]]></abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>35441970</pmid><doi>10.1007/s11547-022-01470-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9056-4122</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1826-6983 |
| ispartof | Radiologia medica, 2022-06, Vol.127 (6), p.664-672 |
| issn | 1826-6983 0033-8362 1826-6983 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2652863352 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Blood flow Blood volume Brain Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - pathology Cerebrovascular Circulation - physiology Computed tomography Contrast Media Diagnostic Radiology Glioma - diagnostic imaging Glioma - pathology Humans Imaging Interventional Radiology Magnetic resonance Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy Medical imaging Medicine Medicine & Public Health Neuroradiology Perfusion Permeability Radiology Retrospective Studies Tomography Tumors Ultrasound |
| title | Assessment of brain tumors by magnetic resonance dynamic susceptibility contrast perfusion-weighted imaging and computed tomography perfusion: a comparison study |
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