Hypersecretion of OmlA antigen in Corynebacterium glutamicum through high-throughput based development process

Outer membrane lipoprotein A (OmlA) is a vaccine antigen against porcine contagious pleuropneumonia (PCP), a disease severely affecting the swine industry. Here, we aimed to systematically potentiate the secretory production of OmlA in Corynebacterium glutamicum ( C. glutamicum ), a widely used micr...

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Veröffentlicht in:	Applied microbiology and biotechnology 2022-04, Vol.106 (8), p.2953-2967
Hauptverfasser:	Sun, Manman, Gao, Alex Xiong, Ledesma-Amaro, Rodrigo, Li, An, Wang, Rongbin, Nie, Jianqi, Zheng, Pei, Yang, Yankun, Bai, Zhonghu, Liu, Xiuxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacillus pleuropneumoniae Animals Antigens Biomedical and Life Sciences Bioreactors Biotechnological Products and Process Engineering Biotechnology Corynebacteria Corynebacterium glutamicum Corynebacterium glutamicum - genetics Corynebacterium glutamicum - metabolism Fermentation Food industry Immunity Life Sciences Lipoprotein(a) - metabolism Mass transfer Microbial Genetics and Genomics Microbiology Optimization Physiological aspects Pleuropneumonia Swine Vaccines
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