Tenascin-C restricts reactive astrogliosis in the ischemic brain

•De novo expression of TnC post stroke is associated with reactive astrocytes.•TnC restricts astrogliosis in the ischemic brain.•TnC supports ramification of reactive astrocytes.•Astrocytic TnC stimulates microglial migration. Cellular responses in glia play a key role in regulating brain remodeling...

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Veröffentlicht in:	Matrix biology 2022-06, Vol.110, p.1-15
Hauptverfasser:	Dzyubenko, Egor, Manrique-Castano, Daniel, Pillath-Eilers, Matthias, Vasileiadou, Paraskevi, Reinhard, Jacqueline, Faissner, Andreas, Hermann, Dirk M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecan Astrocyte morphology Astrocytes Cell adhesion Cerebral blood flow Extracellular matrix Focal cerebral ischemia Glial plasticity Glial scar Gliosis Intercellular adhesion molecule 1 Ischemia Microglia Neuronal-glial interactions Neuroplasticity Proteoglycans Stem cells Stroke Tenascin Tenascin C Wound healing
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