Pregnane X receptor (PXR) represses osteoblast differentiation through repression of the Hedgehog signaling pathway

The pregnane X receptor (PXR, NR1I2) belongs to the nuclear receptor family and functions as a xenobiotic and endobiotic sensor by binding to various molecules through its relatively flexible ligand-binding domain. In addition to these well-known canonical roles, we previously reported that PXR repr...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Experimental cell research 2022-07, Vol.416 (1), p.113156-113156, Article 113156
Hauptverfasser:	Saeki, Naoya, Itoh, Yuki, Kanai, Rinka, Itoh, Shousaku, Inubushi, Toshihiro, Akiyama, Shigehisa, Inui-Yamamoto, Chizuko, Abe, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Hedgehog Hedgehog Proteins - metabolism Osteoblasts Osteoblasts - metabolism Osteogenesis Pregnane X receptor Pregnane X Receptor - genetics Receptors, Cytoplasmic and Nuclear Receptors, Steroid - genetics Receptors, Steroid - metabolism Serum Albumin, Bovine Smoothened
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!