miR-223-3p contributes to suppressing NLRP3 inflammasome activation in Streptococcus equi ssp. zooepidemicus infection

Streptococcus equi subsp. zooepidemicus (SEZ) is an essential pathogen in a range of species, causing a worldwide variety of diseases, such as meningitis, endocarditis, and septicaemia. Studies have shown that microRNAs (miRNAs), which regulate target genes at the post-transcriptional level, play an...

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Veröffentlicht in:	Veterinary microbiology 2022-06, Vol.269, p.109430-109430, Article 109430
Hauptverfasser:	Li, Guochao, Zong, Xueqing, Cheng, Yun, Xu, Jianqi, Deng, Jingfei, Huang, Yunfei, Ma, Chunquan, Fu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase-1 Computer applications Endocarditis IL-1β Infections Inflammasomes Inflammasomes - genetics Inflammasomes - metabolism Inflammation Inflammation - metabolism Inflammation - veterinary Interleukin 18 Intravenous administration Macrophages Meningitis Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miR-223–3p miRNA NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Post-transcription Septicemia Streptococcal Infections - veterinary Streptococcus equi Streptococcus equi - genetics Streptococcus equi - metabolism Streptococcus equi subsp. zooepidemicus Therapeutic targets
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