Two-photon microscopy with enhanced resolution and signal-to-background ratio using hollow Gaussian beam excitation

Two-photon microscopy (TPM) offers deeper imaging depth inside the scattering medium, however, it suffers from limited resolution owing to the longer excitation wavelength. We demonstrate the use of a hollow Gaussian beam (HGB) at the therapeutic window to improve the resolution and signal-to-backgr...

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Veröffentlicht in:	Optics letters 2022-04, Vol.47 (8), p.2048-2051
Hauptverfasser:	Ul Alam, Sabir, Kumar Soni, Niraj, Srinivasa Rao, A, He, Hongsen, Ren, Yu-Xuan, Wong, Kenneth K Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beads Excitation Fluorescence Gaussian beams (optics) Imaging Mice Microscopy Microscopy - methods Normal Distribution Photon beams Photons Point spread functions
Online-Zugang:	Volltext
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