Interleukin‐6 signaling requires EHD1‐mediated alteration of membrane rafts

Interleukin‐6 (IL‐6) is involved in many inflammatory diseases. IL‐6 binds to membrane‐bound IL‐6 receptor α (IL‐6Rα) (classic signaling) or soluble IL‐6Rα (trans‐signaling); this complex then associates with the signal‐transducing membrane protein gp130. IL‐6Rα and gp130 float on membrane (i.e., li...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FEBS journal 2022-10, Vol.289 (19), p.5914-5932
Hauptverfasser:	Woo, Joo Hong, Park, Soo Jung, Park, Sang Myun, Joe, Eun‐hye, Jou, Ilo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholera Cholera toxin Cholesterol Clustering Cytokines EHD1 Fluorescence Fusion protein Glycoprotein gp130 Homology IL‐6 inflammation Inflammatory diseases Interleukin 6 Lipid rafts Lipids Membrane proteins membrane raft Membranes Phosphorylation Proteins Rafts Receptor density Receptors Regulatory mechanisms (biology) Signaling STAT3 Stat3 protein Toxins Waterborne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!