Protective Effects of Sauropus Androgynus Leaf Extract against Isoproterenol Induced Cardiotoxicity
The current research work focuses on the identification of cardioprotective effect of the ethanolic extract of Sauropus androgynus (EESA) leaves. Sauropus androgynus leaves are being utilized in folk and ayurvedic medicines in India to treat cardiovascular diseases like myocardial infraction, athero...
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| Veröffentlicht in: | Cardiovascular toxicology 2022-06, Vol.22 (6), p.579-591 |
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| creator | S., Preethi Kumar, Hitesh C., Ramesh A., Sowmya B. K., Niveditha Ajmeer, Ramkishan Jain, Vikas |
| description | The current research work focuses on the identification of cardioprotective effect of the ethanolic extract of
Sauropus androgynus
(EESA) leaves.
Sauropus androgynus
leaves are being utilized in folk and ayurvedic medicines in India to treat cardiovascular diseases like myocardial infraction, atherosclerosis, and venous thrombosis. However, the cardioprotective effects associated with the leaf extract of this plant has not yet been established. Methods: The identification of cardioprotective effects of the ethanolic extract of
Sauropus androgynus
(EESA) leaves was performed using in vitro and in vivo models. The cell culture studies were performed using cardio myoblast cells (H9C2) and in vivo cardioprotective effects of EESA was assessed in albino wistar rats employing isoproterenol (ISO) as cardiotoxic agent. The animals were divided into six treatment groups and myocardial infraction was induced at 14
th
day followed by the treatment with therapeutic doses of EESA (100, 200 and 400 mg/kg) for next two days. Various biochemical and histopathological parameters were evaluated in animals kept under control and treatment groups. Results: The in vitro cell line studies revealed a positive impact on H9C2 cells. The ethanolic extract of
Sauropus androgynus
depicted low toxicity on cardiomyoblast cells and significant proliferation was observed after treatment. The results from animal studies have shown 1.7 times reduction in serum LDH (151.9 ± 1.302) and CPK (237.6 ± 5.781) levels with EESA treated groups compared to toxic control. EESA also significantly increased the antioxidant enzyme levels, which are responsible for cardioprotective effects in animals. Conclusion: This research study reveals that EESA possess antioxidant activity and also provides a protective role against myocardial infarction induced by ISO. We conclude that EESA could be a potential candidate to prevent and treat cardiotoxic consequences of high catecholamine levels. |
| doi_str_mv | 10.1007/s12012-022-09739-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2651684451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A706385210</galeid><sourcerecordid>A706385210</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-2718c3c298d5e03adecfd8bcc6c3fde651fcc1c0d61e4998bfe14364ef9d4a3a3</originalsourceid><addsrcrecordid>eNp9kV1rFDEUhgdR7If-AS8k4E1vpuZzJrlclrVdWFBovQ7Z5GRJmU3WZEa6_96MWy2KSAg5nDzvyzm8TfOO4GuCcf-xEIoJbTGtV_VMteJFc06EULUl1Mu5ZrjtFRZnzUUpD7iStBOvmzMmOJWKyPPGfslpBDuG74BW3teqoOTRnZlyOkwFLaLLaXeMtdyA8Wj1OGZjR2R2JsQyonVJh9khQ0wDWkc3WXBoabILaUyPwYbx-KZ55c1Q4O3Te9l8_bS6X962m8836-Vi01rO6djSnkjLLFXSCcDMOLDeya21nWXeQSeIt5ZY7DoCXCm59UA46zh45bhhhl02VyffOtG3Ccqo96FYGAYTIU1F191JJzkXpKIf_kIf0pRjna5SHadEkp4_UzszgA7Rp3n52VQvetwxKSjBlbr-B1WPg32wKYIPtf-HgJ4ENqdSMnh9yGFv8lETrOdk9SlZXfPSP5PVooreP008bffgfkt-RVkBdgJK_Yo7yM8r_cf2B3xDrog</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2664218174</pqid></control><display><type>article</type><title>Protective Effects of Sauropus Androgynus Leaf Extract against Isoproterenol Induced Cardiotoxicity</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>S., Preethi ; Kumar, Hitesh ; C., Ramesh ; A., Sowmya B. ; K., Niveditha ; Ajmeer, Ramkishan ; Jain, Vikas</creator><creatorcontrib>S., Preethi ; Kumar, Hitesh ; C., Ramesh ; A., Sowmya B. ; K., Niveditha ; Ajmeer, Ramkishan ; Jain, Vikas</creatorcontrib><description>The current research work focuses on the identification of cardioprotective effect of the ethanolic extract of
Sauropus androgynus
(EESA) leaves.
Sauropus androgynus
leaves are being utilized in folk and ayurvedic medicines in India to treat cardiovascular diseases like myocardial infraction, atherosclerosis, and venous thrombosis. However, the cardioprotective effects associated with the leaf extract of this plant has not yet been established. Methods: The identification of cardioprotective effects of the ethanolic extract of
Sauropus androgynus
(EESA) leaves was performed using in vitro and in vivo models. The cell culture studies were performed using cardio myoblast cells (H9C2) and in vivo cardioprotective effects of EESA was assessed in albino wistar rats employing isoproterenol (ISO) as cardiotoxic agent. The animals were divided into six treatment groups and myocardial infraction was induced at 14
th
day followed by the treatment with therapeutic doses of EESA (100, 200 and 400 mg/kg) for next two days. Various biochemical and histopathological parameters were evaluated in animals kept under control and treatment groups. Results: The in vitro cell line studies revealed a positive impact on H9C2 cells. The ethanolic extract of
Sauropus androgynus
depicted low toxicity on cardiomyoblast cells and significant proliferation was observed after treatment. The results from animal studies have shown 1.7 times reduction in serum LDH (151.9 ± 1.302) and CPK (237.6 ± 5.781) levels with EESA treated groups compared to toxic control. EESA also significantly increased the antioxidant enzyme levels, which are responsible for cardioprotective effects in animals. Conclusion: This research study reveals that EESA possess antioxidant activity and also provides a protective role against myocardial infarction induced by ISO. We conclude that EESA could be a potential candidate to prevent and treat cardiotoxic consequences of high catecholamine levels.</description><identifier>ISSN: 1530-7905</identifier><identifier>EISSN: 1559-0259</identifier><identifier>DOI: 10.1007/s12012-022-09739-5</identifier><identifier>PMID: 35428918</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Animals ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Arteriosclerosis ; Atherosclerosis ; Biocompatibility ; Biomedical and Life Sciences ; Biomedicine ; Blood clot ; Cardiac glycosides ; Cardiology ; Cardiotonic agents ; Cardiotoxicity ; Cardiotoxicity - metabolism ; Cardiotoxicity - pathology ; Cardiovascular diseases ; Catecholamine ; Catecholamines ; Cell culture ; Cell proliferation ; Health aspects ; In vivo methods and tests ; Isoproterenol ; Isoproterenol - toxicity ; Leaves ; Medicine, Ayurvedic ; Medicine, Botanic ; Medicine, Herbal ; Methylene blue ; Myoblasts ; Myocardial infarction ; Myocardium - pathology ; Pharmacology/Toxicology ; Plant extracts ; Plant Extracts - pharmacology ; Rats ; Sauropus androgynus ; Thromboembolism ; Thrombosis ; Toxicity</subject><ispartof>Cardiovascular toxicology, 2022-06, Vol.22 (6), p.579-591</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-2718c3c298d5e03adecfd8bcc6c3fde651fcc1c0d61e4998bfe14364ef9d4a3a3</citedby><cites>FETCH-LOGICAL-c442t-2718c3c298d5e03adecfd8bcc6c3fde651fcc1c0d61e4998bfe14364ef9d4a3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12012-022-09739-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12012-022-09739-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35428918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>S., Preethi</creatorcontrib><creatorcontrib>Kumar, Hitesh</creatorcontrib><creatorcontrib>C., Ramesh</creatorcontrib><creatorcontrib>A., Sowmya B.</creatorcontrib><creatorcontrib>K., Niveditha</creatorcontrib><creatorcontrib>Ajmeer, Ramkishan</creatorcontrib><creatorcontrib>Jain, Vikas</creatorcontrib><title>Protective Effects of Sauropus Androgynus Leaf Extract against Isoproterenol Induced Cardiotoxicity</title><title>Cardiovascular toxicology</title><addtitle>Cardiovasc Toxicol</addtitle><addtitle>Cardiovasc Toxicol</addtitle><description>The current research work focuses on the identification of cardioprotective effect of the ethanolic extract of
Sauropus androgynus
(EESA) leaves.
Sauropus androgynus
leaves are being utilized in folk and ayurvedic medicines in India to treat cardiovascular diseases like myocardial infraction, atherosclerosis, and venous thrombosis. However, the cardioprotective effects associated with the leaf extract of this plant has not yet been established. Methods: The identification of cardioprotective effects of the ethanolic extract of
Sauropus androgynus
(EESA) leaves was performed using in vitro and in vivo models. The cell culture studies were performed using cardio myoblast cells (H9C2) and in vivo cardioprotective effects of EESA was assessed in albino wistar rats employing isoproterenol (ISO) as cardiotoxic agent. The animals were divided into six treatment groups and myocardial infraction was induced at 14
th
day followed by the treatment with therapeutic doses of EESA (100, 200 and 400 mg/kg) for next two days. Various biochemical and histopathological parameters were evaluated in animals kept under control and treatment groups. Results: The in vitro cell line studies revealed a positive impact on H9C2 cells. The ethanolic extract of
Sauropus androgynus
depicted low toxicity on cardiomyoblast cells and significant proliferation was observed after treatment. The results from animal studies have shown 1.7 times reduction in serum LDH (151.9 ± 1.302) and CPK (237.6 ± 5.781) levels with EESA treated groups compared to toxic control. EESA also significantly increased the antioxidant enzyme levels, which are responsible for cardioprotective effects in animals. Conclusion: This research study reveals that EESA possess antioxidant activity and also provides a protective role against myocardial infarction induced by ISO. We conclude that EESA could be a potential candidate to prevent and treat cardiotoxic consequences of high catecholamine levels.</description><subject>Analysis</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood clot</subject><subject>Cardiac glycosides</subject><subject>Cardiology</subject><subject>Cardiotonic agents</subject><subject>Cardiotoxicity</subject><subject>Cardiotoxicity - metabolism</subject><subject>Cardiotoxicity - pathology</subject><subject>Cardiovascular diseases</subject><subject>Catecholamine</subject><subject>Catecholamines</subject><subject>Cell culture</subject><subject>Cell proliferation</subject><subject>Health aspects</subject><subject>In vivo methods and tests</subject><subject>Isoproterenol</subject><subject>Isoproterenol - toxicity</subject><subject>Leaves</subject><subject>Medicine, Ayurvedic</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Methylene blue</subject><subject>Myoblasts</subject><subject>Myocardial infarction</subject><subject>Myocardium - pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Sauropus androgynus</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Toxicity</subject><issn>1530-7905</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV1rFDEUhgdR7If-AS8k4E1vpuZzJrlclrVdWFBovQ7Z5GRJmU3WZEa6_96MWy2KSAg5nDzvyzm8TfOO4GuCcf-xEIoJbTGtV_VMteJFc06EULUl1Mu5ZrjtFRZnzUUpD7iStBOvmzMmOJWKyPPGfslpBDuG74BW3teqoOTRnZlyOkwFLaLLaXeMtdyA8Wj1OGZjR2R2JsQyonVJh9khQ0wDWkc3WXBoabILaUyPwYbx-KZ55c1Q4O3Te9l8_bS6X962m8836-Vi01rO6djSnkjLLFXSCcDMOLDeya21nWXeQSeIt5ZY7DoCXCm59UA46zh45bhhhl02VyffOtG3Ccqo96FYGAYTIU1F191JJzkXpKIf_kIf0pRjna5SHadEkp4_UzszgA7Rp3n52VQvetwxKSjBlbr-B1WPg32wKYIPtf-HgJ4ENqdSMnh9yGFv8lETrOdk9SlZXfPSP5PVooreP008bffgfkt-RVkBdgJK_Yo7yM8r_cf2B3xDrog</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>S., Preethi</creator><creator>Kumar, Hitesh</creator><creator>C., Ramesh</creator><creator>A., Sowmya B.</creator><creator>K., Niveditha</creator><creator>Ajmeer, Ramkishan</creator><creator>Jain, Vikas</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220601</creationdate><title>Protective Effects of Sauropus Androgynus Leaf Extract against Isoproterenol Induced Cardiotoxicity</title><author>S., Preethi ; 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Sauropus androgynus
(EESA) leaves.
Sauropus androgynus
leaves are being utilized in folk and ayurvedic medicines in India to treat cardiovascular diseases like myocardial infraction, atherosclerosis, and venous thrombosis. However, the cardioprotective effects associated with the leaf extract of this plant has not yet been established. Methods: The identification of cardioprotective effects of the ethanolic extract of
Sauropus androgynus
(EESA) leaves was performed using in vitro and in vivo models. The cell culture studies were performed using cardio myoblast cells (H9C2) and in vivo cardioprotective effects of EESA was assessed in albino wistar rats employing isoproterenol (ISO) as cardiotoxic agent. The animals were divided into six treatment groups and myocardial infraction was induced at 14
th
day followed by the treatment with therapeutic doses of EESA (100, 200 and 400 mg/kg) for next two days. Various biochemical and histopathological parameters were evaluated in animals kept under control and treatment groups. Results: The in vitro cell line studies revealed a positive impact on H9C2 cells. The ethanolic extract of
Sauropus androgynus
depicted low toxicity on cardiomyoblast cells and significant proliferation was observed after treatment. The results from animal studies have shown 1.7 times reduction in serum LDH (151.9 ± 1.302) and CPK (237.6 ± 5.781) levels with EESA treated groups compared to toxic control. EESA also significantly increased the antioxidant enzyme levels, which are responsible for cardioprotective effects in animals. Conclusion: This research study reveals that EESA possess antioxidant activity and also provides a protective role against myocardial infarction induced by ISO. We conclude that EESA could be a potential candidate to prevent and treat cardiotoxic consequences of high catecholamine levels.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35428918</pmid><doi>10.1007/s12012-022-09739-5</doi><tpages>13</tpages></addata></record> |
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| subjects | Analysis Animals Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Arteriosclerosis Atherosclerosis Biocompatibility Biomedical and Life Sciences Biomedicine Blood clot Cardiac glycosides Cardiology Cardiotonic agents Cardiotoxicity Cardiotoxicity - metabolism Cardiotoxicity - pathology Cardiovascular diseases Catecholamine Catecholamines Cell culture Cell proliferation Health aspects In vivo methods and tests Isoproterenol Isoproterenol - toxicity Leaves Medicine, Ayurvedic Medicine, Botanic Medicine, Herbal Methylene blue Myoblasts Myocardial infarction Myocardium - pathology Pharmacology/Toxicology Plant extracts Plant Extracts - pharmacology Rats Sauropus androgynus Thromboembolism Thrombosis Toxicity |
| title | Protective Effects of Sauropus Androgynus Leaf Extract against Isoproterenol Induced Cardiotoxicity |
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