Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat
Vascular dementia (VaD) is the second cause of dementia after Alzheimer’s disease. Ligustilide (LIG) is one of the main active ingredients of traditional Chinese medicines, such as Angelica . Studies have reported that LIG could protect against VaD. However, the mechanism is still confused. In this...
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| Veröffentlicht in: | Metabolic brain disease 2022-06, Vol.37 (5), p.1401-1414 |
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| creator | Peng, Dong Qiao, Han-Zi Tan, Hong-Yu Wang, Yi-Xue Luo, Dan Qiao, Li-Jun Cai, Ye-Feng Zhang, Shi-Jie Wang, Qi Guan, Li |
| description | Vascular dementia (VaD) is the second cause of dementia after Alzheimer’s disease. Ligustilide (LIG) is one of the main active ingredients of traditional Chinese medicines, such as
Angelica
. Studies have reported that LIG could protect against VaD. However, the mechanism is still confused. In this study, we employed a bilateral common carotid artery occlusion rat model to study. LIG (20 or 40 mg/kg/day) and Nimodipine (20 mg/kg) were orally administered to the VaD rats for four weeks. Morris water maze test showed that LIG effectively ameliorated learning and memory impairment in VaD rats. LIG obviously reduced neuronal oxidative stress damage and the level of homocysteine in the brain of VaD rats. Western blot results showed that pro-apoptotic protein Bax and cleaved caspase 3 increased and anti-apoptotic protein Bcl-2 decreased in the hippocampi of VaD rats. But after LIG treatment, these changes were reversed. Moreover, Nissl staining result showed that LIG could reduce neuronal degeneration in VaD rats. Furthermore, LIG enhanced the expressions of P-AMPK and Sirtuin1(SIRT1) in VaD rats. In conclusion, these studies indicated that LIG could ameliorate cognitive impairment in VaD rats, which might be related to AMPK/SIRT1 pathway activation. |
| doi_str_mv | 10.1007/s11011-022-00947-0 |
| format | Article |
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Angelica
. Studies have reported that LIG could protect against VaD. However, the mechanism is still confused. In this study, we employed a bilateral common carotid artery occlusion rat model to study. LIG (20 or 40 mg/kg/day) and Nimodipine (20 mg/kg) were orally administered to the VaD rats for four weeks. Morris water maze test showed that LIG effectively ameliorated learning and memory impairment in VaD rats. LIG obviously reduced neuronal oxidative stress damage and the level of homocysteine in the brain of VaD rats. Western blot results showed that pro-apoptotic protein Bax and cleaved caspase 3 increased and anti-apoptotic protein Bcl-2 decreased in the hippocampi of VaD rats. But after LIG treatment, these changes were reversed. Moreover, Nissl staining result showed that LIG could reduce neuronal degeneration in VaD rats. Furthermore, LIG enhanced the expressions of P-AMPK and Sirtuin1(SIRT1) in VaD rats. In conclusion, these studies indicated that LIG could ameliorate cognitive impairment in VaD rats, which might be related to AMPK/SIRT1 pathway activation.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-022-00947-0</identifier><identifier>PMID: 35420377</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer's disease ; Apoptosis ; BAX protein ; Bcl-2 protein ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain damage ; Carotid artery ; Caspase-3 ; Cerebral blood flow ; Cognitive ability ; Degeneration ; Dementia ; Dementia disorders ; Herbal medicine ; Hippocampus ; Homocysteine ; Impairment ; Ischemia ; Maze learning ; Metabolic Diseases ; Neurodegeneration ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Nimodipine ; Occlusion ; Oncology ; Oral administration ; Original Article ; Oxidative stress ; Proteins ; Rodents ; SIRT1 protein ; Traditional Chinese medicine ; Vascular dementia</subject><ispartof>Metabolic brain disease, 2022-06, Vol.37 (5), p.1401-1414</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-47b594ed4166b31bab1c43e88af39825c720760f82ca33d0e26c6cfb11def6d13</citedby><cites>FETCH-LOGICAL-c375t-47b594ed4166b31bab1c43e88af39825c720760f82ca33d0e26c6cfb11def6d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-022-00947-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-022-00947-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35420377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Dong</creatorcontrib><creatorcontrib>Qiao, Han-Zi</creatorcontrib><creatorcontrib>Tan, Hong-Yu</creatorcontrib><creatorcontrib>Wang, Yi-Xue</creatorcontrib><creatorcontrib>Luo, Dan</creatorcontrib><creatorcontrib>Qiao, Li-Jun</creatorcontrib><creatorcontrib>Cai, Ye-Feng</creatorcontrib><creatorcontrib>Zhang, Shi-Jie</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Guan, Li</creatorcontrib><title>Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>Vascular dementia (VaD) is the second cause of dementia after Alzheimer’s disease. Ligustilide (LIG) is one of the main active ingredients of traditional Chinese medicines, such as
Angelica
. Studies have reported that LIG could protect against VaD. However, the mechanism is still confused. In this study, we employed a bilateral common carotid artery occlusion rat model to study. LIG (20 or 40 mg/kg/day) and Nimodipine (20 mg/kg) were orally administered to the VaD rats for four weeks. Morris water maze test showed that LIG effectively ameliorated learning and memory impairment in VaD rats. LIG obviously reduced neuronal oxidative stress damage and the level of homocysteine in the brain of VaD rats. Western blot results showed that pro-apoptotic protein Bax and cleaved caspase 3 increased and anti-apoptotic protein Bcl-2 decreased in the hippocampi of VaD rats. But after LIG treatment, these changes were reversed. Moreover, Nissl staining result showed that LIG could reduce neuronal degeneration in VaD rats. Furthermore, LIG enhanced the expressions of P-AMPK and Sirtuin1(SIRT1) in VaD rats. In conclusion, these studies indicated that LIG could ameliorate cognitive impairment in VaD rats, which might be related to AMPK/SIRT1 pathway activation.</description><subject>Alzheimer's disease</subject><subject>Apoptosis</subject><subject>BAX protein</subject><subject>Bcl-2 protein</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain damage</subject><subject>Carotid artery</subject><subject>Caspase-3</subject><subject>Cerebral blood flow</subject><subject>Cognitive ability</subject><subject>Degeneration</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Herbal medicine</subject><subject>Hippocampus</subject><subject>Homocysteine</subject><subject>Impairment</subject><subject>Ischemia</subject><subject>Maze learning</subject><subject>Metabolic Diseases</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nimodipine</subject><subject>Occlusion</subject><subject>Oncology</subject><subject>Oral administration</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Rodents</subject><subject>SIRT1 protein</subject><subject>Traditional Chinese medicine</subject><subject>Vascular dementia</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1v1DAQhi0EotvCH-CALHHpJXTGju3kWFVQqi6iKuWGZDnOZHGVj8VOFvXf42ULSBw4zWGe953Rw9grhLcIYM4SIiAWIEQBUJemgCdshcrIwkitnrIVVJUqTFnDETtO6R4ApML6OTuSqhQgjVmxr-uwWdIc-tASdwP1YYpupsT9tBnDHHbEw7B1IQ40znwXHD__eHN99vnq9g751s3ffrgHHka-c8kvvYu8pT2ZuVzzgj3rXJ_o5eM8YV_ev7u7-FCsP11eXZyvCy-NmovSNKouqS1R60Zi4xr0paSqcp2sK6G8EWA0dJXwTsoWSGivfdcgttTpFuUJOz30buP0faE02yEkT33vRpqWZIVWIJTU1R598w96Py1xzN9lSmsUKGqdKXGgfJxSitTZbQyDiw8Wwe7d24N7m93bX-4t5NDrx-qlGaj9E_ktOwPyAKS8GjcU_97-T-1PkxGOVQ</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Peng, Dong</creator><creator>Qiao, Han-Zi</creator><creator>Tan, Hong-Yu</creator><creator>Wang, Yi-Xue</creator><creator>Luo, Dan</creator><creator>Qiao, Li-Jun</creator><creator>Cai, Ye-Feng</creator><creator>Zhang, Shi-Jie</creator><creator>Wang, Qi</creator><creator>Guan, Li</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20220601</creationdate><title>Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat</title><author>Peng, Dong ; Qiao, Han-Zi ; Tan, Hong-Yu ; Wang, Yi-Xue ; Luo, Dan ; Qiao, Li-Jun ; Cai, Ye-Feng ; Zhang, Shi-Jie ; Wang, Qi ; Guan, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-47b594ed4166b31bab1c43e88af39825c720760f82ca33d0e26c6cfb11def6d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Apoptosis</topic><topic>BAX protein</topic><topic>Bcl-2 protein</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain damage</topic><topic>Carotid artery</topic><topic>Caspase-3</topic><topic>Cerebral blood flow</topic><topic>Cognitive ability</topic><topic>Degeneration</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Herbal medicine</topic><topic>Hippocampus</topic><topic>Homocysteine</topic><topic>Impairment</topic><topic>Ischemia</topic><topic>Maze learning</topic><topic>Metabolic Diseases</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nimodipine</topic><topic>Occlusion</topic><topic>Oncology</topic><topic>Oral administration</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Rodents</topic><topic>SIRT1 protein</topic><topic>Traditional Chinese medicine</topic><topic>Vascular dementia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Dong</creatorcontrib><creatorcontrib>Qiao, Han-Zi</creatorcontrib><creatorcontrib>Tan, Hong-Yu</creatorcontrib><creatorcontrib>Wang, Yi-Xue</creatorcontrib><creatorcontrib>Luo, Dan</creatorcontrib><creatorcontrib>Qiao, Li-Jun</creatorcontrib><creatorcontrib>Cai, Ye-Feng</creatorcontrib><creatorcontrib>Zhang, Shi-Jie</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Guan, Li</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Dong</au><au>Qiao, Han-Zi</au><au>Tan, Hong-Yu</au><au>Wang, Yi-Xue</au><au>Luo, Dan</au><au>Qiao, Li-Jun</au><au>Cai, Ye-Feng</au><au>Zhang, Shi-Jie</au><au>Wang, Qi</au><au>Guan, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>37</volume><issue>5</issue><spage>1401</spage><epage>1414</epage><pages>1401-1414</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>Vascular dementia (VaD) is the second cause of dementia after Alzheimer’s disease. Ligustilide (LIG) is one of the main active ingredients of traditional Chinese medicines, such as
Angelica
. Studies have reported that LIG could protect against VaD. However, the mechanism is still confused. In this study, we employed a bilateral common carotid artery occlusion rat model to study. LIG (20 or 40 mg/kg/day) and Nimodipine (20 mg/kg) were orally administered to the VaD rats for four weeks. Morris water maze test showed that LIG effectively ameliorated learning and memory impairment in VaD rats. LIG obviously reduced neuronal oxidative stress damage and the level of homocysteine in the brain of VaD rats. Western blot results showed that pro-apoptotic protein Bax and cleaved caspase 3 increased and anti-apoptotic protein Bcl-2 decreased in the hippocampi of VaD rats. But after LIG treatment, these changes were reversed. Moreover, Nissl staining result showed that LIG could reduce neuronal degeneration in VaD rats. Furthermore, LIG enhanced the expressions of P-AMPK and Sirtuin1(SIRT1) in VaD rats. In conclusion, these studies indicated that LIG could ameliorate cognitive impairment in VaD rats, which might be related to AMPK/SIRT1 pathway activation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35420377</pmid><doi>10.1007/s11011-022-00947-0</doi><tpages>14</tpages></addata></record> |
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| subjects | Alzheimer's disease Apoptosis BAX protein Bcl-2 protein Biochemistry Biomedical and Life Sciences Biomedicine Brain damage Carotid artery Caspase-3 Cerebral blood flow Cognitive ability Degeneration Dementia Dementia disorders Herbal medicine Hippocampus Homocysteine Impairment Ischemia Maze learning Metabolic Diseases Neurodegeneration Neurodegenerative diseases Neurology Neurosciences Nimodipine Occlusion Oncology Oral administration Original Article Oxidative stress Proteins Rodents SIRT1 protein Traditional Chinese medicine Vascular dementia |
| title | Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat |
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