SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity

Emerging evidence indicates that the accretion of senescent cells is linked to metabolic disorders. However, the underlying mechanisms and metabolic consequences of cellular senescence in obesity remain obscure. In this study, we found that obese adipocytes are senescence-susceptible cells accompani...

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Veröffentlicht in:	Cell metabolism 2022-05, Vol.34 (5), p.702-718.e5
Hauptverfasser:	Lee, Gung, Kim, Ye Young, Jang, Hagoon, Han, Ji Seul, Nahmgoong, Hahn, Park, Yoon Jeong, Han, Sang Mun, Cho, Changyun, Lim, Sangsoo, Noh, Jung-Ran, Oh, Won Keun, Lee, Chul-Ho, Kim, Sun, Kim, Jae Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocyte adipose tissue inflammation cellular senescence DNA repair process energy homeostasis insulin resistance obesity PARP1 SASP SREBP1c
Online-Zugang:	Volltext
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