Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota
Inflammatory bowel disease (IBD) poses a threat to health and compromises the immune system and gut microflora. The present study aimed to explore the effects of rice protein (RP) purified from rice dregs (RD) on acute colitis induced by dextran sulfate sodium (DSS) and the underlying mechanisms. Re...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2022-04, Vol.70 (16), p.4952-4965 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Huang, Zhenghua Yang, Wenting Wang, Xiaoya Guo, Fanghua Cheng, Yibin Cao, Leipeng Zhu, Wenting Sun, Yong Xiong, Hua |
| description | Inflammatory bowel disease (IBD) poses a threat to health and compromises the immune system and gut microflora. The present study aimed to explore the effects of rice protein (RP) purified from rice dregs (RD) on acute colitis induced by dextran sulfate sodium (DSS) and the underlying mechanisms. Results showed that RP treatment could alleviate the loss of body weight, colon shortening and injury, and the level of disease activity index, repair colonic function (claudin-1, ZO-1 and occludin), regulate inflammatory factors, and restore oxidative balance (malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and total antioxidant capability (T-AOC)) in mice. Also, RP treatment could activate the Kelch-like ECH-associating protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2) signaling pathway, mediate the expression of downstream antioxidant protease (NQO-1, HO-1, and Gclc), regulate gut microbiota by enhancing the relative abundance of Akkermansia and increasing the value of F/B, and adjust short-chain fatty acid levels to alleviate DSS-induced colitis in mice. Thus, RP may be an effective therapeutic dietary resource for ulcerative colitis. |
| doi_str_mv | 10.1021/acs.jafc.2c00585 |
| format | Article |
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The present study aimed to explore the effects of rice protein (RP) purified from rice dregs (RD) on acute colitis induced by dextran sulfate sodium (DSS) and the underlying mechanisms. Results showed that RP treatment could alleviate the loss of body weight, colon shortening and injury, and the level of disease activity index, repair colonic function (claudin-1, ZO-1 and occludin), regulate inflammatory factors, and restore oxidative balance (malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and total antioxidant capability (T-AOC)) in mice. Also, RP treatment could activate the Kelch-like ECH-associating protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2) signaling pathway, mediate the expression of downstream antioxidant protease (NQO-1, HO-1, and Gclc), regulate gut microbiota by enhancing the relative abundance of Akkermansia and increasing the value of F/B, and adjust short-chain fatty acid levels to alleviate DSS-induced colitis in mice. Thus, RP may be an effective therapeutic dietary resource for ulcerative colitis.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.2c00585</identifier><identifier>PMID: 35412826</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Antioxidants - metabolism ; Bioactive Constituents, Metabolites, and Functions ; Colitis - chemically induced ; Colitis - drug therapy ; Colitis - genetics ; Colon - metabolism ; Dextran Sulfate - metabolism ; Disease Models, Animal ; Gastrointestinal Microbiome ; Kelch-Like ECH-Associated Protein 1 - metabolism ; Mice ; Mice, Inbred C57BL ; NF-E2-Related Factor 2 - metabolism ; Oryza - metabolism ; Oxidative Stress</subject><ispartof>Journal of agricultural and food chemistry, 2022-04, Vol.70 (16), p.4952-4965</ispartof><rights>2022 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a336t-37a76e2bfd7c1afc6ae6acd8f0fd61f332e46e48fab0479b43fc7c5c87fc96503</citedby><cites>FETCH-LOGICAL-a336t-37a76e2bfd7c1afc6ae6acd8f0fd61f332e46e48fab0479b43fc7c5c87fc96503</cites><orcidid>0000-0002-2198-0162 ; 0000-0003-2324-7180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.2c00585$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.2c00585$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27081,27929,27930,56743,56793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35412826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Zhenghua</creatorcontrib><creatorcontrib>Yang, Wenting</creatorcontrib><creatorcontrib>Wang, Xiaoya</creatorcontrib><creatorcontrib>Guo, Fanghua</creatorcontrib><creatorcontrib>Cheng, Yibin</creatorcontrib><creatorcontrib>Cao, Leipeng</creatorcontrib><creatorcontrib>Zhu, Wenting</creatorcontrib><creatorcontrib>Sun, Yong</creatorcontrib><creatorcontrib>Xiong, Hua</creatorcontrib><title>Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Inflammatory bowel disease (IBD) poses a threat to health and compromises the immune system and gut microflora. The present study aimed to explore the effects of rice protein (RP) purified from rice dregs (RD) on acute colitis induced by dextran sulfate sodium (DSS) and the underlying mechanisms. Results showed that RP treatment could alleviate the loss of body weight, colon shortening and injury, and the level of disease activity index, repair colonic function (claudin-1, ZO-1 and occludin), regulate inflammatory factors, and restore oxidative balance (malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and total antioxidant capability (T-AOC)) in mice. Also, RP treatment could activate the Kelch-like ECH-associating protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2) signaling pathway, mediate the expression of downstream antioxidant protease (NQO-1, HO-1, and Gclc), regulate gut microbiota by enhancing the relative abundance of Akkermansia and increasing the value of F/B, and adjust short-chain fatty acid levels to alleviate DSS-induced colitis in mice. Thus, RP may be an effective therapeutic dietary resource for ulcerative colitis.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Bioactive Constituents, Metabolites, and Functions</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Colitis - genetics</subject><subject>Colon - metabolism</subject><subject>Dextran Sulfate - metabolism</subject><subject>Disease Models, Animal</subject><subject>Gastrointestinal Microbiome</subject><subject>Kelch-Like ECH-Associated Protein 1 - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Oryza - metabolism</subject><subject>Oxidative Stress</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxS0EotvCnRPykcNmsZ3YyR7LAmWloiIK52jijBdXTlL8p2o_GV-vTrNwwxd7rN97mplHyBvONpwJ_h502NyA0RuhGZONfEZWXApWSM6b52TFMlM0UvETchrCDWOskTV7SU5KWXHRCLUif_Zjn0L0Fpx7oN_81CeNPf1uNc5VRDvS8wGdnTxEDPQj3kcPI71OzuQPej31Ng3F7DLrdpOz0QZ6Z2GR62jHA42_kO7HrM8VOPoBvLfo1_Rrhg_whFzd2z6_7rJl9BjCmsKY-8BDcgtwkWLmtZ86O0V4RV4YcAFfH-8z8vPzpx-7L8Xl1cV-d35ZQFmqWJQ11ApFZ_pa87woBahA941hplfclKXASmHVGOhYVW-7qjS61lI3tdFbJVl5Rt4tvrd--p3yAO1gg0bnYMQphVaoajufSmSULWjuMQSPpr31dgD_0HLWznG1Oa52jqs9xpUlb4_uqRuw_yf4m08G1gvwJJ2Sz-sL__d7BFZwpkk</recordid><startdate>20220427</startdate><enddate>20220427</enddate><creator>Huang, Zhenghua</creator><creator>Yang, Wenting</creator><creator>Wang, Xiaoya</creator><creator>Guo, Fanghua</creator><creator>Cheng, Yibin</creator><creator>Cao, Leipeng</creator><creator>Zhu, Wenting</creator><creator>Sun, Yong</creator><creator>Xiong, Hua</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2198-0162</orcidid><orcidid>https://orcid.org/0000-0003-2324-7180</orcidid></search><sort><creationdate>20220427</creationdate><title>Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota</title><author>Huang, Zhenghua ; Yang, Wenting ; Wang, Xiaoya ; Guo, Fanghua ; Cheng, Yibin ; Cao, Leipeng ; Zhu, Wenting ; Sun, Yong ; Xiong, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-37a76e2bfd7c1afc6ae6acd8f0fd61f332e46e48fab0479b43fc7c5c87fc96503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Bioactive Constituents, Metabolites, and Functions</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Colitis - genetics</topic><topic>Colon - metabolism</topic><topic>Dextran Sulfate - metabolism</topic><topic>Disease Models, Animal</topic><topic>Gastrointestinal Microbiome</topic><topic>Kelch-Like ECH-Associated Protein 1 - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Oryza - metabolism</topic><topic>Oxidative Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Zhenghua</creatorcontrib><creatorcontrib>Yang, Wenting</creatorcontrib><creatorcontrib>Wang, Xiaoya</creatorcontrib><creatorcontrib>Guo, Fanghua</creatorcontrib><creatorcontrib>Cheng, Yibin</creatorcontrib><creatorcontrib>Cao, Leipeng</creatorcontrib><creatorcontrib>Zhu, Wenting</creatorcontrib><creatorcontrib>Sun, Yong</creatorcontrib><creatorcontrib>Xiong, Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Zhenghua</au><au>Yang, Wenting</au><au>Wang, Xiaoya</au><au>Guo, Fanghua</au><au>Cheng, Yibin</au><au>Cao, Leipeng</au><au>Zhu, Wenting</au><au>Sun, Yong</au><au>Xiong, Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2022-04-27</date><risdate>2022</risdate><volume>70</volume><issue>16</issue><spage>4952</spage><epage>4965</epage><pages>4952-4965</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Inflammatory bowel disease (IBD) poses a threat to health and compromises the immune system and gut microflora. The present study aimed to explore the effects of rice protein (RP) purified from rice dregs (RD) on acute colitis induced by dextran sulfate sodium (DSS) and the underlying mechanisms. Results showed that RP treatment could alleviate the loss of body weight, colon shortening and injury, and the level of disease activity index, repair colonic function (claudin-1, ZO-1 and occludin), regulate inflammatory factors, and restore oxidative balance (malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and total antioxidant capability (T-AOC)) in mice. Also, RP treatment could activate the Kelch-like ECH-associating protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2) signaling pathway, mediate the expression of downstream antioxidant protease (NQO-1, HO-1, and Gclc), regulate gut microbiota by enhancing the relative abundance of Akkermansia and increasing the value of F/B, and adjust short-chain fatty acid levels to alleviate DSS-induced colitis in mice. Thus, RP may be an effective therapeutic dietary resource for ulcerative colitis.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>35412826</pmid><doi>10.1021/acs.jafc.2c00585</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-2198-0162</orcidid><orcidid>https://orcid.org/0000-0003-2324-7180</orcidid></addata></record> |
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| subjects | Animals Antioxidants - metabolism Bioactive Constituents, Metabolites, and Functions Colitis - chemically induced Colitis - drug therapy Colitis - genetics Colon - metabolism Dextran Sulfate - metabolism Disease Models, Animal Gastrointestinal Microbiome Kelch-Like ECH-Associated Protein 1 - metabolism Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - metabolism Oryza - metabolism Oxidative Stress |
| title | Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota |
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