Punicalagin Attenuates Neuronal Apoptosis by Upregulating 5‑Hydroxymethylcytosine in the Diabetic Mouse Brain

Punicalagin exerts neuroprotective activity by improving AMP-activated kinase (AMPK) and mitochondrial Krebs cycle. AMPK and Krebs cycle metabolites regulate 5-hydroxymethylcytosine (5hmC) via acting on ten-eleven translocation (TET) enzymes. Therefore, we hypothesized that punicalagin inhibits diab...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of agricultural and food chemistry 2022-04, Vol.70 (16), p.4995-5004
Hauptverfasser:	He, Xin, Pei, Shengjie, Meng, Xiangyuan, Hua, Qinglian, Zhang, Tianyu, Wang, Yan, Zhang, Zhizhao, Zhu, Xinyu, Liu, Run, Guo, Yurong, Chen, Lei, Li, Duo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Apoptosis Bioactive Constituents, Metabolites, and Functions Brain - metabolism Diabetes Mellitus - metabolism Hydrolyzable Tannins Mice Mice, Inbred C57BL
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!