In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Proteolysis targeting chimeras (PROTACs) are molecules that induce protein degradation via formation of ternary complexes between an E3 ubiquitin ligase and a target protein. The rational design of PROTACs requires accurate knowledge of the native configuration of the PROTAC-induced ternary complex....

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Veröffentlicht in:	Journal of medicinal chemistry 2022-04, Vol.65 (8), p.6116-6132
Hauptverfasser:	Liao, Junzhuo, Nie, Xueqing, Unarta, Ilona Christy, Ericksen, Spencer S, Tang, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Chimera - metabolism Computer Simulation Intercellular Signaling Peptides and Proteins - metabolism Proteolysis Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
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