Responsive hydrogel-based microneedle dressing for diabetic wound healing
Wound healing is a critical challenge in diabetic patients, mainly due to long-term dysglycemia and its related pathological complications. Subcutaneous insulin injection represents a typical clinical solution, while the low controllability of insulin administration commonly leads to a result far fr...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2022-05, Vol.1 (18), p.351-3511 |
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| creator | Guo, Zhaoyang Liu, Haiyang Shi, Zhekun Lin, Lulu Li, Yinping Wang, Miao Pan, Guoqing Lei, Yifeng Xue, Longjian |
| description | Wound healing is a critical challenge in diabetic patients, mainly due to long-term dysglycemia and its related pathological complications. Subcutaneous insulin injection represents a typical clinical solution, while the low controllability of insulin administration commonly leads to a result far from the optimal therapeutic effect. In this work, we developed a glucose-responsive insulin-releasing hydrogel for microneedle dressing fabrication and then investigated its effects on diabetic wound healing. The hydrogel system was composed of biocompatible gelatin methacrylate (GelMa), glucose-responsive monomer 4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic acid (AFPBA) and gluconic insulin (G-insulin), and the Gel-AFPBA-ins hydrogel-based microneedle dressing was developed by replicating PDMS molds. The resultant hydrogel microneedle dressing exhibited adequate mechanical properties, high biocompatibility, glucose-responsive insulin release behavior upon exposure to different glucose solutions, and potent adhesion to the skin compared to hydrogels without microstructures. The microneedle dressing could accelerate the diabetic wound healing process with decreased inflammatory reaction, enhanced collagen deposition on the regenerated tissue sites, and improved blood glucose control in animals. Therefore, the glucose-responsive insulin-releasing hydrogel microneedle dressing is effective in diabetic wound management and has potential for treatment of other chronic skin injuries.
A glucose-responsive insulin-releasing hydrogel microneedle dressing was developed with the aim to accelerate wound healing in type 1 diabetic mice. |
| doi_str_mv | 10.1039/d2tb00126h |
| format | Article |
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A glucose-responsive insulin-releasing hydrogel microneedle dressing was developed with the aim to accelerate wound healing in type 1 diabetic mice.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d2tb00126h</identifier><identifier>PMID: 35416225</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biocompatibility ; Blood glucose ; Collagen ; Complications ; Diabetes ; Diabetes mellitus ; Fabrication ; Gelatin ; Glucose ; Hydrogels ; Inflammation ; Insulin ; Mechanical properties ; Mold dressing ; Needles ; Skin ; Skin injuries ; Wound healing</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2022-05, Vol.1 (18), p.351-3511</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-e8b6661f8e4eae5cef9e5d1cfdfc7dffb749d2ed3fce74b0dc76066409903b7f3</citedby><cites>FETCH-LOGICAL-c378t-e8b6661f8e4eae5cef9e5d1cfdfc7dffb749d2ed3fce74b0dc76066409903b7f3</cites><orcidid>0000-0002-4024-2827 ; 0000-0002-3523-6887 ; 0000-0001-5512-747X ; 0000-0001-5187-796X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35416225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Zhaoyang</creatorcontrib><creatorcontrib>Liu, Haiyang</creatorcontrib><creatorcontrib>Shi, Zhekun</creatorcontrib><creatorcontrib>Lin, Lulu</creatorcontrib><creatorcontrib>Li, Yinping</creatorcontrib><creatorcontrib>Wang, Miao</creatorcontrib><creatorcontrib>Pan, Guoqing</creatorcontrib><creatorcontrib>Lei, Yifeng</creatorcontrib><creatorcontrib>Xue, Longjian</creatorcontrib><title>Responsive hydrogel-based microneedle dressing for diabetic wound healing</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Wound healing is a critical challenge in diabetic patients, mainly due to long-term dysglycemia and its related pathological complications. Subcutaneous insulin injection represents a typical clinical solution, while the low controllability of insulin administration commonly leads to a result far from the optimal therapeutic effect. In this work, we developed a glucose-responsive insulin-releasing hydrogel for microneedle dressing fabrication and then investigated its effects on diabetic wound healing. The hydrogel system was composed of biocompatible gelatin methacrylate (GelMa), glucose-responsive monomer 4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic acid (AFPBA) and gluconic insulin (G-insulin), and the Gel-AFPBA-ins hydrogel-based microneedle dressing was developed by replicating PDMS molds. The resultant hydrogel microneedle dressing exhibited adequate mechanical properties, high biocompatibility, glucose-responsive insulin release behavior upon exposure to different glucose solutions, and potent adhesion to the skin compared to hydrogels without microstructures. The microneedle dressing could accelerate the diabetic wound healing process with decreased inflammatory reaction, enhanced collagen deposition on the regenerated tissue sites, and improved blood glucose control in animals. Therefore, the glucose-responsive insulin-releasing hydrogel microneedle dressing is effective in diabetic wound management and has potential for treatment of other chronic skin injuries.
A glucose-responsive insulin-releasing hydrogel microneedle dressing was developed with the aim to accelerate wound healing in type 1 diabetic mice.</description><subject>Biocompatibility</subject><subject>Blood glucose</subject><subject>Collagen</subject><subject>Complications</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Fabrication</subject><subject>Gelatin</subject><subject>Glucose</subject><subject>Hydrogels</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Mechanical properties</subject><subject>Mold dressing</subject><subject>Needles</subject><subject>Skin</subject><subject>Skin injuries</subject><subject>Wound healing</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpd0c1LwzAYBvAgihtzF-9KwYsI1Xy0aXLU-bHBQJAJ3kqbvNk6umYmrbL_3ujmBHNJ4P3xkDxB6JTga4KZvNG0LTEmlC8OUJ_iFMdZSsTh_ozfemjo_RKHJQgXLDlGPZYmhFOa9tHkBfzaNr76gGix0c7OoY7LwoOOVpVytgHQNUTagfdVM4-MdZGuihLaSkWftmt0tICiDqMTdGSK2sNwtw_Q6-PDbDSOp89Pk9HtNFYsE20MouScEyMggQJSBUZCqoky2qhMG1NmidQUNDMKsqTEWmUcc55gKTErM8MG6HKbu3b2vQPf5qvKK6jrogHb-ZzyREopBCGBXvyjS9u5JtwuKE4EESE5qKutCs_13oHJ165aFW6TE5x_d5zf09ndT8fjgM93kV25Ar2nv40GcLYFzqv99O-T2BfnEYFh</recordid><startdate>20220511</startdate><enddate>20220511</enddate><creator>Guo, Zhaoyang</creator><creator>Liu, Haiyang</creator><creator>Shi, Zhekun</creator><creator>Lin, Lulu</creator><creator>Li, Yinping</creator><creator>Wang, Miao</creator><creator>Pan, Guoqing</creator><creator>Lei, Yifeng</creator><creator>Xue, Longjian</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4024-2827</orcidid><orcidid>https://orcid.org/0000-0002-3523-6887</orcidid><orcidid>https://orcid.org/0000-0001-5512-747X</orcidid><orcidid>https://orcid.org/0000-0001-5187-796X</orcidid></search><sort><creationdate>20220511</creationdate><title>Responsive hydrogel-based microneedle dressing for diabetic wound healing</title><author>Guo, Zhaoyang ; Liu, Haiyang ; Shi, Zhekun ; Lin, Lulu ; Li, Yinping ; Wang, Miao ; Pan, Guoqing ; Lei, Yifeng ; Xue, Longjian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-e8b6661f8e4eae5cef9e5d1cfdfc7dffb749d2ed3fce74b0dc76066409903b7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biocompatibility</topic><topic>Blood glucose</topic><topic>Collagen</topic><topic>Complications</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Fabrication</topic><topic>Gelatin</topic><topic>Glucose</topic><topic>Hydrogels</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Mechanical properties</topic><topic>Mold dressing</topic><topic>Needles</topic><topic>Skin</topic><topic>Skin injuries</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Zhaoyang</creatorcontrib><creatorcontrib>Liu, Haiyang</creatorcontrib><creatorcontrib>Shi, Zhekun</creatorcontrib><creatorcontrib>Lin, Lulu</creatorcontrib><creatorcontrib>Li, Yinping</creatorcontrib><creatorcontrib>Wang, Miao</creatorcontrib><creatorcontrib>Pan, Guoqing</creatorcontrib><creatorcontrib>Lei, Yifeng</creatorcontrib><creatorcontrib>Xue, Longjian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Zhaoyang</au><au>Liu, Haiyang</au><au>Shi, Zhekun</au><au>Lin, Lulu</au><au>Li, Yinping</au><au>Wang, Miao</au><au>Pan, Guoqing</au><au>Lei, Yifeng</au><au>Xue, Longjian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responsive hydrogel-based microneedle dressing for diabetic wound healing</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2022-05-11</date><risdate>2022</risdate><volume>1</volume><issue>18</issue><spage>351</spage><epage>3511</epage><pages>351-3511</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Wound healing is a critical challenge in diabetic patients, mainly due to long-term dysglycemia and its related pathological complications. Subcutaneous insulin injection represents a typical clinical solution, while the low controllability of insulin administration commonly leads to a result far from the optimal therapeutic effect. In this work, we developed a glucose-responsive insulin-releasing hydrogel for microneedle dressing fabrication and then investigated its effects on diabetic wound healing. The hydrogel system was composed of biocompatible gelatin methacrylate (GelMa), glucose-responsive monomer 4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic acid (AFPBA) and gluconic insulin (G-insulin), and the Gel-AFPBA-ins hydrogel-based microneedle dressing was developed by replicating PDMS molds. The resultant hydrogel microneedle dressing exhibited adequate mechanical properties, high biocompatibility, glucose-responsive insulin release behavior upon exposure to different glucose solutions, and potent adhesion to the skin compared to hydrogels without microstructures. The microneedle dressing could accelerate the diabetic wound healing process with decreased inflammatory reaction, enhanced collagen deposition on the regenerated tissue sites, and improved blood glucose control in animals. Therefore, the glucose-responsive insulin-releasing hydrogel microneedle dressing is effective in diabetic wound management and has potential for treatment of other chronic skin injuries.
A glucose-responsive insulin-releasing hydrogel microneedle dressing was developed with the aim to accelerate wound healing in type 1 diabetic mice.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35416225</pmid><doi>10.1039/d2tb00126h</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4024-2827</orcidid><orcidid>https://orcid.org/0000-0002-3523-6887</orcidid><orcidid>https://orcid.org/0000-0001-5512-747X</orcidid><orcidid>https://orcid.org/0000-0001-5187-796X</orcidid></addata></record> |
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| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2022-05, Vol.1 (18), p.351-3511 |
| issn | 2050-750X 2050-7518 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Biocompatibility Blood glucose Collagen Complications Diabetes Diabetes mellitus Fabrication Gelatin Glucose Hydrogels Inflammation Insulin Mechanical properties Mold dressing Needles Skin Skin injuries Wound healing |
| title | Responsive hydrogel-based microneedle dressing for diabetic wound healing |
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