Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs

[Display omitted] This paper describes a new approach to the early-stage optimization of topical products and selection of lead formulation candidates. It demonstrates the application of open flow microperfusion in vitro in conjunction with the Franz diffusion cell to compare time-resolved, 24-hour...

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Veröffentlicht in:	International journal of pharmaceutics 2022-05, Vol.620, p.121737-121737, Article 121737
Hauptverfasser:	Hummer, Joanna, Birngruber, Thomas, Sinner, Frank, Page, Leanne, Toner, Frank, Roper, Clive S., Moore, David J., Baker, Mark B., Boncheva Bettex, Mila
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Anti-Inflammatory Agents, Non-Steroidal - metabolism Diclofenac - metabolism Formulation optimization Franz diffusion cell In vitro Open flow microperfusion Passive diffusion Pharmaceutical Preparations - metabolism Skin - metabolism Skin Absorption Topical diclofenac
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