Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity
Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for t...
Gespeichert in:
| Veröffentlicht in: | Phytochemistry (Oxford) 2022-07, Vol.199, p.113187-113187, Article 113187 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 113187 |
|---|---|
| container_issue | |
| container_start_page | 113187 |
| container_title | Phytochemistry (Oxford) |
| container_volume | 199 |
| creator | Jiang, Chunyu Yang, Mengyue Zhao, Chunxue Liu, Fangshen Yang, Hangao Li, Zhanlin Han, Tong Lin, Bin Li, Dahong Hua, Huiming |
| description | Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC50 values of 16.34, 15.63 and 21.33 μM and was further investigated for colony formation and apoptosis in HepG2 cells.
The manuscript covered twenty one abietane diterpenes including seven undescribed ones from Cephalotaxus oliveri, and metaglyptin A further investigated for colony formation and apoptosis in HepG2 cells. [Display omitted]
•Seven undescribed abietane diterpenes were isolated and characterized.•Some compounds exhibited potent antitumor activity.•Metaglyptin A can inhibit colony formation.•Metaglyptin A can induce cell apoptosis. |
| doi_str_mv | 10.1016/j.phytochem.2022.113187 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2649593574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0031942222001030</els_id><sourcerecordid>2649593574</sourcerecordid><originalsourceid>FETCH-LOGICAL-c301t-e825dd713406ff85e71ce289aa0c70f88167c403dd634911ebc39c04fc971c333</originalsourceid><addsrcrecordid>eNqFkE1v2zAMQIWhxZql-wutjr3Yoyz56xgE6zYgwy7tWVAkelZgR54kO8u_r4p0ve5CguAjCT5C7hnkDFj15ZBP_Tk63eOYF1AUOWOcNfUHskqRZ7wGuCIrAM6yVhTFDfkUwgEAyrKqPpIbXgoomWhXRG_2FqM6IjU2op_wiIF23o009kjjyf4OVB0NHVAtqeM6usWpV4OL6u-c6sEu6C39qULM6cnGPtHRxnl0niod7WLj-ZZcd2oI-Pktr8nz49en7fds9-vbj-1ml2kOLGbYFKUxNeMCqq5rSqyZxqJplQJdQ9c0rKq1AG5MxUXLGO41bzWITreJ5JyvycNl7-TdnxlDlKMNGochvefmIItKtGXLy1oktL6g2rsQPHZy8nZU_iwZyFfD8iDfDctXw_JiOE3evR2Z9yOa97l_ShOwuQCYXl0sehm0xaNGYz3qKI2z_z3yAkUWkfE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2649593574</pqid></control><display><type>article</type><title>Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Jiang, Chunyu ; Yang, Mengyue ; Zhao, Chunxue ; Liu, Fangshen ; Yang, Hangao ; Li, Zhanlin ; Han, Tong ; Lin, Bin ; Li, Dahong ; Hua, Huiming</creator><creatorcontrib>Jiang, Chunyu ; Yang, Mengyue ; Zhao, Chunxue ; Liu, Fangshen ; Yang, Hangao ; Li, Zhanlin ; Han, Tong ; Lin, Bin ; Li, Dahong ; Hua, Huiming</creatorcontrib><description>Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC50 values of 16.34, 15.63 and 21.33 μM and was further investigated for colony formation and apoptosis in HepG2 cells.
The manuscript covered twenty one abietane diterpenes including seven undescribed ones from Cephalotaxus oliveri, and metaglyptin A further investigated for colony formation and apoptosis in HepG2 cells. [Display omitted]
•Seven undescribed abietane diterpenes were isolated and characterized.•Some compounds exhibited potent antitumor activity.•Metaglyptin A can inhibit colony formation.•Metaglyptin A can induce cell apoptosis.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/j.phytochem.2022.113187</identifier><identifier>PMID: 35405149</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Abietane diterpenes ; Abietanes - chemistry ; Abietanes - pharmacology ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - pharmacology ; Antitumor activity ; Cell Line, Tumor ; Cephalotaxaceae ; Cephalotaxus - chemistry ; Cephalotaxus oliveri Mast ; Diterpenes - chemistry ; Molecular Structure ; Plant Leaves - chemistry</subject><ispartof>Phytochemistry (Oxford), 2022-07, Vol.199, p.113187-113187, Article 113187</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-e825dd713406ff85e71ce289aa0c70f88167c403dd634911ebc39c04fc971c333</citedby><cites>FETCH-LOGICAL-c301t-e825dd713406ff85e71ce289aa0c70f88167c403dd634911ebc39c04fc971c333</cites><orcidid>0000-0002-6964-4619</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031942222001030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35405149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Chunyu</creatorcontrib><creatorcontrib>Yang, Mengyue</creatorcontrib><creatorcontrib>Zhao, Chunxue</creatorcontrib><creatorcontrib>Liu, Fangshen</creatorcontrib><creatorcontrib>Yang, Hangao</creatorcontrib><creatorcontrib>Li, Zhanlin</creatorcontrib><creatorcontrib>Han, Tong</creatorcontrib><creatorcontrib>Lin, Bin</creatorcontrib><creatorcontrib>Li, Dahong</creatorcontrib><creatorcontrib>Hua, Huiming</creatorcontrib><title>Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC50 values of 16.34, 15.63 and 21.33 μM and was further investigated for colony formation and apoptosis in HepG2 cells.
The manuscript covered twenty one abietane diterpenes including seven undescribed ones from Cephalotaxus oliveri, and metaglyptin A further investigated for colony formation and apoptosis in HepG2 cells. [Display omitted]
•Seven undescribed abietane diterpenes were isolated and characterized.•Some compounds exhibited potent antitumor activity.•Metaglyptin A can inhibit colony formation.•Metaglyptin A can induce cell apoptosis.</description><subject>Abietane diterpenes</subject><subject>Abietanes - chemistry</subject><subject>Abietanes - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antitumor activity</subject><subject>Cell Line, Tumor</subject><subject>Cephalotaxaceae</subject><subject>Cephalotaxus - chemistry</subject><subject>Cephalotaxus oliveri Mast</subject><subject>Diterpenes - chemistry</subject><subject>Molecular Structure</subject><subject>Plant Leaves - chemistry</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v2zAMQIWhxZql-wutjr3Yoyz56xgE6zYgwy7tWVAkelZgR54kO8u_r4p0ve5CguAjCT5C7hnkDFj15ZBP_Tk63eOYF1AUOWOcNfUHskqRZ7wGuCIrAM6yVhTFDfkUwgEAyrKqPpIbXgoomWhXRG_2FqM6IjU2op_wiIF23o009kjjyf4OVB0NHVAtqeM6usWpV4OL6u-c6sEu6C39qULM6cnGPtHRxnl0niod7WLj-ZZcd2oI-Pktr8nz49en7fds9-vbj-1ml2kOLGbYFKUxNeMCqq5rSqyZxqJplQJdQ9c0rKq1AG5MxUXLGO41bzWITreJ5JyvycNl7-TdnxlDlKMNGochvefmIItKtGXLy1oktL6g2rsQPHZy8nZU_iwZyFfD8iDfDctXw_JiOE3evR2Z9yOa97l_ShOwuQCYXl0sehm0xaNGYz3qKI2z_z3yAkUWkfE</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Jiang, Chunyu</creator><creator>Yang, Mengyue</creator><creator>Zhao, Chunxue</creator><creator>Liu, Fangshen</creator><creator>Yang, Hangao</creator><creator>Li, Zhanlin</creator><creator>Han, Tong</creator><creator>Lin, Bin</creator><creator>Li, Dahong</creator><creator>Hua, Huiming</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6964-4619</orcidid></search><sort><creationdate>202207</creationdate><title>Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity</title><author>Jiang, Chunyu ; Yang, Mengyue ; Zhao, Chunxue ; Liu, Fangshen ; Yang, Hangao ; Li, Zhanlin ; Han, Tong ; Lin, Bin ; Li, Dahong ; Hua, Huiming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-e825dd713406ff85e71ce289aa0c70f88167c403dd634911ebc39c04fc971c333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abietane diterpenes</topic><topic>Abietanes - chemistry</topic><topic>Abietanes - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antitumor activity</topic><topic>Cell Line, Tumor</topic><topic>Cephalotaxaceae</topic><topic>Cephalotaxus - chemistry</topic><topic>Cephalotaxus oliveri Mast</topic><topic>Diterpenes - chemistry</topic><topic>Molecular Structure</topic><topic>Plant Leaves - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Chunyu</creatorcontrib><creatorcontrib>Yang, Mengyue</creatorcontrib><creatorcontrib>Zhao, Chunxue</creatorcontrib><creatorcontrib>Liu, Fangshen</creatorcontrib><creatorcontrib>Yang, Hangao</creatorcontrib><creatorcontrib>Li, Zhanlin</creatorcontrib><creatorcontrib>Han, Tong</creatorcontrib><creatorcontrib>Lin, Bin</creatorcontrib><creatorcontrib>Li, Dahong</creatorcontrib><creatorcontrib>Hua, Huiming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Chunyu</au><au>Yang, Mengyue</au><au>Zhao, Chunxue</au><au>Liu, Fangshen</au><au>Yang, Hangao</au><au>Li, Zhanlin</au><au>Han, Tong</au><au>Lin, Bin</au><au>Li, Dahong</au><au>Hua, Huiming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2022-07</date><risdate>2022</risdate><volume>199</volume><spage>113187</spage><epage>113187</epage><pages>113187-113187</pages><artnum>113187</artnum><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC50 values of 16.34, 15.63 and 21.33 μM and was further investigated for colony formation and apoptosis in HepG2 cells.
The manuscript covered twenty one abietane diterpenes including seven undescribed ones from Cephalotaxus oliveri, and metaglyptin A further investigated for colony formation and apoptosis in HepG2 cells. [Display omitted]
•Seven undescribed abietane diterpenes were isolated and characterized.•Some compounds exhibited potent antitumor activity.•Metaglyptin A can inhibit colony formation.•Metaglyptin A can induce cell apoptosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35405149</pmid><doi>10.1016/j.phytochem.2022.113187</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6964-4619</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9422 |
| ispartof | Phytochemistry (Oxford), 2022-07, Vol.199, p.113187-113187, Article 113187 |
| issn | 0031-9422 1873-3700 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2649593574 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abietane diterpenes Abietanes - chemistry Abietanes - pharmacology Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antitumor activity Cell Line, Tumor Cephalotaxaceae Cephalotaxus - chemistry Cephalotaxus oliveri Mast Diterpenes - chemistry Molecular Structure Plant Leaves - chemistry |
| title | Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T13%3A32%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abietane%20diterpenes%20from%20the%20twigs%20and%20leaves%20of%20Cephalotaxus%20oliveri%20Mast.%20with%20antitumor%20activity&rft.jtitle=Phytochemistry%20(Oxford)&rft.au=Jiang,%20Chunyu&rft.date=2022-07&rft.volume=199&rft.spage=113187&rft.epage=113187&rft.pages=113187-113187&rft.artnum=113187&rft.issn=0031-9422&rft.eissn=1873-3700&rft_id=info:doi/10.1016/j.phytochem.2022.113187&rft_dat=%3Cproquest_cross%3E2649593574%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2649593574&rft_id=info:pmid/35405149&rft_els_id=S0031942222001030&rfr_iscdi=true |