Effectiveness of Autologous Fat Transfer in the Treatment of Scar-Related Conditions: A Systematic Review and Meta-analysis
Background and Aim Autologous fat transfer (AFT) has been introduced as a potential treatment option for scar-tissue and its related symptoms. However, the scientific evidence for its effectiveness remains unclear. This meta-analysis aims to evaluate the available evidence regarding the effectivenes...
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| creator | Al Qurashi, Abdullah A. Siddiqi, Ahmed Kamal Alghamdi, Abdulrahman Abdulaziz Aljalfan, Abdullah Ali N. Almenhali, Ahmed Abdullah Al Jabr, Faisal Ali Rashid, Ahmed Mustafa Almas, Talal Menezes, Ritesh G. |
| description | Background and Aim
Autologous fat transfer (AFT) has been introduced as a potential treatment option for scar-tissue and its related symptoms. However, the scientific evidence for its effectiveness remains unclear. This meta-analysis aims to evaluate the available evidence regarding the effectiveness of autologous fat transfer for the treatment of scar-tissue and its related conditions.
Methods
PubMed/Medline database was queried from its inception till the end of November 2021. All the relevant studies assessing the effect of autologous fat transfer in the treatment of scar-related conditions were pooled in using a random-effects model.
Results
9 studies (
n
=179) were included in the meta-analysis. Pooled analysis demonstrates significant improvement in all subscales of the POSAS patient score with most prominent in color 2.4 points (95% CI 1.78–3.041), stiffness 2.9 points (95% CI 2.33–3.45), irregularity 2.2 points (95% CI 1.093–3.297) and thickness 1.8 points (95% CI 0.804–2.719), respectively. Pain and itch improved relatively lesser, 1.3 points (95% CI 0.958–1.674) and 0.6 points (95% CI 0.169–1.215), respectively. The POSAS observer scale showed a relatively lower improvement with the least in vascularity 0.5 points (95% CI 0.098–0.96), pigmentation 0.8 points (95% CI 0.391–1.276) and surface area 0.8 points (95% CI 0.34–1.25). Thickness improved by 1.4 points (95% CI 0.582–2.3), relief 1.0 points (95% CI 0.461–1.545) and pliability 1.5 points (95% CI 1.039–2.036).
Conclusion
Our findings demonstrate that autologous fat transfer (AFT) is a promising treatment for scar-related conditions as it provides beneficial results in the scar quality. Future research should focus on the long-term effects of AFT and high-level evidence studies such as, randomized controlled trials (RCTs) and cohort studies are required.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
. |
| doi_str_mv | 10.1007/s00266-022-02869-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2649587071</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2727850697</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-82b0adbdf78369eca53ebbeb81571ab593b3172bc162c6d55648b2ca73ce62333</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MZNNB-TZMbd5dKqUBHaCu5CkjlTU2aSmmQqF_-8qbcquHARDiHPeU8OD0LPGX3NKNVvCqVcKUI5b6dXAxkeoA3rBCeSd-wh2lChOsKZ-nKEnpRyTSnjWneP0ZGQHWMd7Tfox8k0ga_hFiKUgtOEt2tNc7pKa8GntuLLbGOZIOMQcf0K7Q62LhDrHXvhbSbnMNsKI96lOIYaUixv8RZf7EuFxdbg8TncBviObRzxR6iW2GjnfQnlKXo02bnAs_t6jD6fnlzu3pOzT-8-7LZnxAsqK-m5o3Z046R7oQbwVgpwDlzPpGbWyUE4wTR3ninu1Sil6nrHvdXCg-JCiGP06pB7k9O3FUo1Syge5tlGaGsarrpB9ppq1tCX_6DXac3tv43SXPeSqkE3ih8on1MpGSZzk8Ni894wau7UmIMa09SYX2rM0Jpe3EevboHxT8tvFw0QB6C0p3gF-e_s_8T-BK3ymfc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2727850697</pqid></control><display><type>article</type><title>Effectiveness of Autologous Fat Transfer in the Treatment of Scar-Related Conditions: A Systematic Review and Meta-analysis</title><source>SpringerNature Journals</source><creator>Al Qurashi, Abdullah A. ; Siddiqi, Ahmed Kamal ; Alghamdi, Abdulrahman Abdulaziz ; Aljalfan, Abdullah Ali N. ; Almenhali, Ahmed Abdullah ; Al Jabr, Faisal Ali ; Rashid, Ahmed Mustafa ; Almas, Talal ; Menezes, Ritesh G.</creator><creatorcontrib>Al Qurashi, Abdullah A. ; Siddiqi, Ahmed Kamal ; Alghamdi, Abdulrahman Abdulaziz ; Aljalfan, Abdullah Ali N. ; Almenhali, Ahmed Abdullah ; Al Jabr, Faisal Ali ; Rashid, Ahmed Mustafa ; Almas, Talal ; Menezes, Ritesh G.</creatorcontrib><description>Background and Aim
Autologous fat transfer (AFT) has been introduced as a potential treatment option for scar-tissue and its related symptoms. However, the scientific evidence for its effectiveness remains unclear. This meta-analysis aims to evaluate the available evidence regarding the effectiveness of autologous fat transfer for the treatment of scar-tissue and its related conditions.
Methods
PubMed/Medline database was queried from its inception till the end of November 2021. All the relevant studies assessing the effect of autologous fat transfer in the treatment of scar-related conditions were pooled in using a random-effects model.
Results
9 studies (
n
=179) were included in the meta-analysis. Pooled analysis demonstrates significant improvement in all subscales of the POSAS patient score with most prominent in color 2.4 points (95% CI 1.78–3.041), stiffness 2.9 points (95% CI 2.33–3.45), irregularity 2.2 points (95% CI 1.093–3.297) and thickness 1.8 points (95% CI 0.804–2.719), respectively. Pain and itch improved relatively lesser, 1.3 points (95% CI 0.958–1.674) and 0.6 points (95% CI 0.169–1.215), respectively. The POSAS observer scale showed a relatively lower improvement with the least in vascularity 0.5 points (95% CI 0.098–0.96), pigmentation 0.8 points (95% CI 0.391–1.276) and surface area 0.8 points (95% CI 0.34–1.25). Thickness improved by 1.4 points (95% CI 0.582–2.3), relief 1.0 points (95% CI 0.461–1.545) and pliability 1.5 points (95% CI 1.039–2.036).
Conclusion
Our findings demonstrate that autologous fat transfer (AFT) is a promising treatment for scar-related conditions as it provides beneficial results in the scar quality. Future research should focus on the long-term effects of AFT and high-level evidence studies such as, randomized controlled trials (RCTs) and cohort studies are required.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><identifier>ISSN: 0364-216X</identifier><identifier>EISSN: 1432-5241</identifier><identifier>DOI: 10.1007/s00266-022-02869-9</identifier><identifier>PMID: 35411408</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Body fat ; Clinical trials ; Cohort analysis ; Medical research ; Medicine ; Medicine & Public Health ; Meta-analysis ; Otorhinolaryngology ; Plastic Surgery ; Review ; Scars ; Skin ; Statistical analysis ; Systematic review</subject><ispartof>Aesthetic plastic surgery, 2022-10, Vol.46 (5), p.2564-2572</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2022</rights><rights>2022. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-82b0adbdf78369eca53ebbeb81571ab593b3172bc162c6d55648b2ca73ce62333</citedby><cites>FETCH-LOGICAL-c305t-82b0adbdf78369eca53ebbeb81571ab593b3172bc162c6d55648b2ca73ce62333</cites><orcidid>0000-0001-5612-8626</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00266-022-02869-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00266-022-02869-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35411408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al Qurashi, Abdullah A.</creatorcontrib><creatorcontrib>Siddiqi, Ahmed Kamal</creatorcontrib><creatorcontrib>Alghamdi, Abdulrahman Abdulaziz</creatorcontrib><creatorcontrib>Aljalfan, Abdullah Ali N.</creatorcontrib><creatorcontrib>Almenhali, Ahmed Abdullah</creatorcontrib><creatorcontrib>Al Jabr, Faisal Ali</creatorcontrib><creatorcontrib>Rashid, Ahmed Mustafa</creatorcontrib><creatorcontrib>Almas, Talal</creatorcontrib><creatorcontrib>Menezes, Ritesh G.</creatorcontrib><title>Effectiveness of Autologous Fat Transfer in the Treatment of Scar-Related Conditions: A Systematic Review and Meta-analysis</title><title>Aesthetic plastic surgery</title><addtitle>Aesth Plast Surg</addtitle><addtitle>Aesthetic Plast Surg</addtitle><description>Background and Aim
Autologous fat transfer (AFT) has been introduced as a potential treatment option for scar-tissue and its related symptoms. However, the scientific evidence for its effectiveness remains unclear. This meta-analysis aims to evaluate the available evidence regarding the effectiveness of autologous fat transfer for the treatment of scar-tissue and its related conditions.
Methods
PubMed/Medline database was queried from its inception till the end of November 2021. All the relevant studies assessing the effect of autologous fat transfer in the treatment of scar-related conditions were pooled in using a random-effects model.
Results
9 studies (
n
=179) were included in the meta-analysis. Pooled analysis demonstrates significant improvement in all subscales of the POSAS patient score with most prominent in color 2.4 points (95% CI 1.78–3.041), stiffness 2.9 points (95% CI 2.33–3.45), irregularity 2.2 points (95% CI 1.093–3.297) and thickness 1.8 points (95% CI 0.804–2.719), respectively. Pain and itch improved relatively lesser, 1.3 points (95% CI 0.958–1.674) and 0.6 points (95% CI 0.169–1.215), respectively. The POSAS observer scale showed a relatively lower improvement with the least in vascularity 0.5 points (95% CI 0.098–0.96), pigmentation 0.8 points (95% CI 0.391–1.276) and surface area 0.8 points (95% CI 0.34–1.25). Thickness improved by 1.4 points (95% CI 0.582–2.3), relief 1.0 points (95% CI 0.461–1.545) and pliability 1.5 points (95% CI 1.039–2.036).
Conclusion
Our findings demonstrate that autologous fat transfer (AFT) is a promising treatment for scar-related conditions as it provides beneficial results in the scar quality. Future research should focus on the long-term effects of AFT and high-level evidence studies such as, randomized controlled trials (RCTs) and cohort studies are required.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><subject>Body fat</subject><subject>Clinical trials</subject><subject>Cohort analysis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Review</subject><subject>Scars</subject><subject>Skin</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><issn>0364-216X</issn><issn>1432-5241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MZNNB-TZMbd5dKqUBHaCu5CkjlTU2aSmmQqF_-8qbcquHARDiHPeU8OD0LPGX3NKNVvCqVcKUI5b6dXAxkeoA3rBCeSd-wh2lChOsKZ-nKEnpRyTSnjWneP0ZGQHWMd7Tfox8k0ga_hFiKUgtOEt2tNc7pKa8GntuLLbGOZIOMQcf0K7Q62LhDrHXvhbSbnMNsKI96lOIYaUixv8RZf7EuFxdbg8TncBviObRzxR6iW2GjnfQnlKXo02bnAs_t6jD6fnlzu3pOzT-8-7LZnxAsqK-m5o3Z046R7oQbwVgpwDlzPpGbWyUE4wTR3ninu1Sil6nrHvdXCg-JCiGP06pB7k9O3FUo1Syge5tlGaGsarrpB9ppq1tCX_6DXac3tv43SXPeSqkE3ih8on1MpGSZzk8Ni894wau7UmIMa09SYX2rM0Jpe3EevboHxT8tvFw0QB6C0p3gF-e_s_8T-BK3ymfc</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Al Qurashi, Abdullah A.</creator><creator>Siddiqi, Ahmed Kamal</creator><creator>Alghamdi, Abdulrahman Abdulaziz</creator><creator>Aljalfan, Abdullah Ali N.</creator><creator>Almenhali, Ahmed Abdullah</creator><creator>Al Jabr, Faisal Ali</creator><creator>Rashid, Ahmed Mustafa</creator><creator>Almas, Talal</creator><creator>Menezes, Ritesh G.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5612-8626</orcidid></search><sort><creationdate>20221001</creationdate><title>Effectiveness of Autologous Fat Transfer in the Treatment of Scar-Related Conditions: A Systematic Review and Meta-analysis</title><author>Al Qurashi, Abdullah A. ; Siddiqi, Ahmed Kamal ; Alghamdi, Abdulrahman Abdulaziz ; Aljalfan, Abdullah Ali N. ; Almenhali, Ahmed Abdullah ; Al Jabr, Faisal Ali ; Rashid, Ahmed Mustafa ; Almas, Talal ; Menezes, Ritesh G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-82b0adbdf78369eca53ebbeb81571ab593b3172bc162c6d55648b2ca73ce62333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Body fat</topic><topic>Clinical trials</topic><topic>Cohort analysis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Review</topic><topic>Scars</topic><topic>Skin</topic><topic>Statistical analysis</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al Qurashi, Abdullah A.</creatorcontrib><creatorcontrib>Siddiqi, Ahmed Kamal</creatorcontrib><creatorcontrib>Alghamdi, Abdulrahman Abdulaziz</creatorcontrib><creatorcontrib>Aljalfan, Abdullah Ali N.</creatorcontrib><creatorcontrib>Almenhali, Ahmed Abdullah</creatorcontrib><creatorcontrib>Al Jabr, Faisal Ali</creatorcontrib><creatorcontrib>Rashid, Ahmed Mustafa</creatorcontrib><creatorcontrib>Almas, Talal</creatorcontrib><creatorcontrib>Menezes, Ritesh G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aesthetic plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al Qurashi, Abdullah A.</au><au>Siddiqi, Ahmed Kamal</au><au>Alghamdi, Abdulrahman Abdulaziz</au><au>Aljalfan, Abdullah Ali N.</au><au>Almenhali, Ahmed Abdullah</au><au>Al Jabr, Faisal Ali</au><au>Rashid, Ahmed Mustafa</au><au>Almas, Talal</au><au>Menezes, Ritesh G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of Autologous Fat Transfer in the Treatment of Scar-Related Conditions: A Systematic Review and Meta-analysis</atitle><jtitle>Aesthetic plastic surgery</jtitle><stitle>Aesth Plast Surg</stitle><addtitle>Aesthetic Plast Surg</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>46</volume><issue>5</issue><spage>2564</spage><epage>2572</epage><pages>2564-2572</pages><issn>0364-216X</issn><eissn>1432-5241</eissn><abstract>Background and Aim
Autologous fat transfer (AFT) has been introduced as a potential treatment option for scar-tissue and its related symptoms. However, the scientific evidence for its effectiveness remains unclear. This meta-analysis aims to evaluate the available evidence regarding the effectiveness of autologous fat transfer for the treatment of scar-tissue and its related conditions.
Methods
PubMed/Medline database was queried from its inception till the end of November 2021. All the relevant studies assessing the effect of autologous fat transfer in the treatment of scar-related conditions were pooled in using a random-effects model.
Results
9 studies (
n
=179) were included in the meta-analysis. Pooled analysis demonstrates significant improvement in all subscales of the POSAS patient score with most prominent in color 2.4 points (95% CI 1.78–3.041), stiffness 2.9 points (95% CI 2.33–3.45), irregularity 2.2 points (95% CI 1.093–3.297) and thickness 1.8 points (95% CI 0.804–2.719), respectively. Pain and itch improved relatively lesser, 1.3 points (95% CI 0.958–1.674) and 0.6 points (95% CI 0.169–1.215), respectively. The POSAS observer scale showed a relatively lower improvement with the least in vascularity 0.5 points (95% CI 0.098–0.96), pigmentation 0.8 points (95% CI 0.391–1.276) and surface area 0.8 points (95% CI 0.34–1.25). Thickness improved by 1.4 points (95% CI 0.582–2.3), relief 1.0 points (95% CI 0.461–1.545) and pliability 1.5 points (95% CI 1.039–2.036).
Conclusion
Our findings demonstrate that autologous fat transfer (AFT) is a promising treatment for scar-related conditions as it provides beneficial results in the scar quality. Future research should focus on the long-term effects of AFT and high-level evidence studies such as, randomized controlled trials (RCTs) and cohort studies are required.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35411408</pmid><doi>10.1007/s00266-022-02869-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5612-8626</orcidid></addata></record> |
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| source | SpringerNature Journals |
| subjects | Body fat Clinical trials Cohort analysis Medical research Medicine Medicine & Public Health Meta-analysis Otorhinolaryngology Plastic Surgery Review Scars Skin Statistical analysis Systematic review |
| title | Effectiveness of Autologous Fat Transfer in the Treatment of Scar-Related Conditions: A Systematic Review and Meta-analysis |
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