Biological variation in clozapine and metabolite reporting during therapeutic drug monitoring

•The biological variation of clozapine and norclozapine are defined.•Evidence is provided for the clinical utility of reporting both clozapine and norclozapine levels routinely.•Large inter-individual variation in clozapine metabolism is observed. Clozapine (CLO) is an atypical antipsychotic used in...

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Veröffentlicht in:	Clinica chimica acta 2022-06, Vol.531, p.183-187
Hauptverfasser:	Wickramarachchi, Pasindu, Boyd, Jessica M., Orton, Dennis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse drug reactions Analytical quality targets Biological variation Clozapine Norclozapine Therapeutic drug monitoring
Online-Zugang:	Volltext
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