Clinical Research into Treating Unexplained Recurrent Spontaneous Abortion during Early Pregnancy with the Qing Yi Tiao Mian Formula

•The aim of the present study was to analyze the clinical effect of Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and on the immune balance of T lymphocytes.•45 patients with URSA in 4th-9th week of pregnancy were separated into three gr...

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Veröffentlicht in:Explore (New York, N.Y.) N.Y.), 2023-01, Vol.19 (1), p.52-57
Hauptverfasser: Shen, Ming-Jie, Pan, Ding-Chen, Du, Le, Jiang, Guo-Jing
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Du, Le
Jiang, Guo-Jing
description •The aim of the present study was to analyze the clinical effect of Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and on the immune balance of T lymphocytes.•45 patients with URSA in 4th-9th week of pregnancy were separated into three groups: conventional fetal protection group (n=15), prednisone treatment group (n=10) and QYTM formula treatment group (n=20). These patients would get the treatment once they were diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (an injection of 20 ∼ 40 mg daily) for four weeks. The prednisone treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) +prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) + QYTM formula (one dose per day) for four weeks. In addition, the women who had previously had a normal pregnancy have been enrolled as a control group (n=18). The success rate of the pregnancy in the first trimester was observed in each group, and the proportion of T lymphocytes in the peripheral blood before and after treatment was recorded.•QYTM formula significantly decreased the spontaneous abortion rate in URSA patients during early pregnancy. The mechanism may be closely related to the inhibition of the proliferation of killer lymphocytes represented by CD8+T lymphocytes and natural killer (NK) cells. The present study aims to analyze the clinical effect of the Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and the immune balance of T lymphocytes. With their consent, 45 patients with URSA in weeks 4–9 of pregnancy were separated into three groups, i.e., the conventional fetal protection (n = 15), prednisone treatment (n = 10), and QYTM formula treatment (n = 20) groups. These patients received treatment once they had been diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (20 ∼ 40 mg daily injection) for four weeks. The prednisone treatment group was given progesterone (20 ∼ 40 mg daily injection) + prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (20 ∼ 40 mg daily injection) + QYTM formula (one dose per day) for four weeks. In addition, women who had previously had a normal pregnancy were enrolled as a control group (n = 18). The success rate of the pregna
doi_str_mv 10.1016/j.explore.2022.03.009
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These patients would get the treatment once they were diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (an injection of 20 ∼ 40 mg daily) for four weeks. The prednisone treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) +prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) + QYTM formula (one dose per day) for four weeks. In addition, the women who had previously had a normal pregnancy have been enrolled as a control group (n=18). The success rate of the pregnancy in the first trimester was observed in each group, and the proportion of T lymphocytes in the peripheral blood before and after treatment was recorded.•QYTM formula significantly decreased the spontaneous abortion rate in URSA patients during early pregnancy. The mechanism may be closely related to the inhibition of the proliferation of killer lymphocytes represented by CD8+T lymphocytes and natural killer (NK) cells. The present study aims to analyze the clinical effect of the Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and the immune balance of T lymphocytes. With their consent, 45 patients with URSA in weeks 4–9 of pregnancy were separated into three groups, i.e., the conventional fetal protection (n = 15), prednisone treatment (n = 10), and QYTM formula treatment (n = 20) groups. These patients received treatment once they had been diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (20 ∼ 40 mg daily injection) for four weeks. The prednisone treatment group was given progesterone (20 ∼ 40 mg daily injection) + prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (20 ∼ 40 mg daily injection) + QYTM formula (one dose per day) for four weeks. In addition, women who had previously had a normal pregnancy were enrolled as a control group (n = 18). The success rate of the pregnancy in the first trimester was observed in each group, and the proportion of T lymphocytes in the peripheral blood before and after treatment was recorded. Among the 20 patients with URSA in the QYTM formula treatment group, 19 remained pregnant. Thus, the success rate during early pregnancy was 95%, which was significantly higher than the conventional fetal protection (53.33%) and prednisone treatment (70%) groups. The CD8+ T and natural killer (NK) cells population in the URSA groups was higher compared with the control group (P &lt; 0.01). The QYTM formula treatment significantly decreased the ratio of CD8+ T lymphocytes (P &lt; 0.01) and NK cells (P &lt; 0.01). The QYTM formula significantly decreased the spontaneous abortion rate in patients with URSA during early pregnancy. The mechanism may be closely related to the inhibition of the killer lymphocytes’ proliferation by CD8+ T lymphocytes and NK cells.</description><identifier>ISSN: 1550-8307</identifier><identifier>EISSN: 1878-7541</identifier><identifier>DOI: 10.1016/j.explore.2022.03.009</identifier><identifier>PMID: 35397998</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abortion, Habitual - drug therapy ; CD8+ T lymphocyte ; Female ; Humans ; Killer Cells, Natural ; natural killer (NK) cells ; Prednisone ; Pregnancy ; Progesterone - therapeutic use ; Qing Yi Tiao Mian (QYTM) formula ; Unexplained recurrent spontaneous abortion (URSA)</subject><ispartof>Explore (New York, N.Y.), 2023-01, Vol.19 (1), p.52-57</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c313t-982c34d275b2c0cb773ed26fc0d7d415e7ede042baffd107566930a0183c68373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.explore.2022.03.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35397998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Ming-Jie</creatorcontrib><creatorcontrib>Pan, Ding-Chen</creatorcontrib><creatorcontrib>Du, Le</creatorcontrib><creatorcontrib>Jiang, Guo-Jing</creatorcontrib><title>Clinical Research into Treating Unexplained Recurrent Spontaneous Abortion during Early Pregnancy with the Qing Yi Tiao Mian Formula</title><title>Explore (New York, N.Y.)</title><addtitle>Explore (NY)</addtitle><description>•The aim of the present study was to analyze the clinical effect of Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and on the immune balance of T lymphocytes.•45 patients with URSA in 4th-9th week of pregnancy were separated into three groups: conventional fetal protection group (n=15), prednisone treatment group (n=10) and QYTM formula treatment group (n=20). These patients would get the treatment once they were diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (an injection of 20 ∼ 40 mg daily) for four weeks. The prednisone treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) +prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) + QYTM formula (one dose per day) for four weeks. In addition, the women who had previously had a normal pregnancy have been enrolled as a control group (n=18). The success rate of the pregnancy in the first trimester was observed in each group, and the proportion of T lymphocytes in the peripheral blood before and after treatment was recorded.•QYTM formula significantly decreased the spontaneous abortion rate in URSA patients during early pregnancy. The mechanism may be closely related to the inhibition of the proliferation of killer lymphocytes represented by CD8+T lymphocytes and natural killer (NK) cells. The present study aims to analyze the clinical effect of the Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and the immune balance of T lymphocytes. With their consent, 45 patients with URSA in weeks 4–9 of pregnancy were separated into three groups, i.e., the conventional fetal protection (n = 15), prednisone treatment (n = 10), and QYTM formula treatment (n = 20) groups. These patients received treatment once they had been diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (20 ∼ 40 mg daily injection) for four weeks. The prednisone treatment group was given progesterone (20 ∼ 40 mg daily injection) + prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (20 ∼ 40 mg daily injection) + QYTM formula (one dose per day) for four weeks. In addition, women who had previously had a normal pregnancy were enrolled as a control group (n = 18). The success rate of the pregnancy in the first trimester was observed in each group, and the proportion of T lymphocytes in the peripheral blood before and after treatment was recorded. Among the 20 patients with URSA in the QYTM formula treatment group, 19 remained pregnant. Thus, the success rate during early pregnancy was 95%, which was significantly higher than the conventional fetal protection (53.33%) and prednisone treatment (70%) groups. The CD8+ T and natural killer (NK) cells population in the URSA groups was higher compared with the control group (P &lt; 0.01). The QYTM formula treatment significantly decreased the ratio of CD8+ T lymphocytes (P &lt; 0.01) and NK cells (P &lt; 0.01). The QYTM formula significantly decreased the spontaneous abortion rate in patients with URSA during early pregnancy. The mechanism may be closely related to the inhibition of the killer lymphocytes’ proliferation by CD8+ T lymphocytes and NK cells.</description><subject>Abortion, Habitual - drug therapy</subject><subject>CD8+ T lymphocyte</subject><subject>Female</subject><subject>Humans</subject><subject>Killer Cells, Natural</subject><subject>natural killer (NK) cells</subject><subject>Prednisone</subject><subject>Pregnancy</subject><subject>Progesterone - therapeutic use</subject><subject>Qing Yi Tiao Mian (QYTM) formula</subject><subject>Unexplained recurrent spontaneous abortion (URSA)</subject><issn>1550-8307</issn><issn>1878-7541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP1DAQhC0EYh_wE0A-cklo20mcnNBqtLustIjX7IGT5didHY8y9mA7wNz54SSagSsnt-SvulRdhLxiUDJgzdttib_2Y4hYcuC8BFECdE_IOWtlW8i6Yk_nua6haAXIM3KR0hZANHXTPCdnohad7Lr2nPxejc47o0f6BRPqaDbU-RzoOqLOzj_SB7_4aOfRzoiZYkSf6dd98Fl7DFOiV32I2QVP7RQXxbWO44F-ivjotTcH-tPlDc0bpJ-X32-Orp0O9IPTnt6EuJtG_YI8G_SY8OXpvSQPN9fr1fvi_uPt3erqvjCCiVx0LTeislzWPTdgeikFWt4MBqy0FatRokWoeK-HwTKQc9ZOgAbWCtO0QopL8ua4dx_D9wlTVjuXDI7jMYniTdXxupEVm9H6iJoYUoo4qH10Ox0PioFaClBbdSpALQUoEGouYNa9PllM_Q7tP9Xfi8_AuyOAc9AfDqNKxqE3aF1Ek5UN7j8WfwBca5vD</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Shen, Ming-Jie</creator><creator>Pan, Ding-Chen</creator><creator>Du, Le</creator><creator>Jiang, Guo-Jing</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202301</creationdate><title>Clinical Research into Treating Unexplained Recurrent Spontaneous Abortion during Early Pregnancy with the Qing Yi Tiao Mian Formula</title><author>Shen, Ming-Jie ; Pan, Ding-Chen ; Du, Le ; Jiang, Guo-Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-982c34d275b2c0cb773ed26fc0d7d415e7ede042baffd107566930a0183c68373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abortion, Habitual - drug therapy</topic><topic>CD8+ T lymphocyte</topic><topic>Female</topic><topic>Humans</topic><topic>Killer Cells, Natural</topic><topic>natural killer (NK) cells</topic><topic>Prednisone</topic><topic>Pregnancy</topic><topic>Progesterone - therapeutic use</topic><topic>Qing Yi Tiao Mian (QYTM) formula</topic><topic>Unexplained recurrent spontaneous abortion (URSA)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Ming-Jie</creatorcontrib><creatorcontrib>Pan, Ding-Chen</creatorcontrib><creatorcontrib>Du, Le</creatorcontrib><creatorcontrib>Jiang, Guo-Jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Explore (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Ming-Jie</au><au>Pan, Ding-Chen</au><au>Du, Le</au><au>Jiang, Guo-Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Research into Treating Unexplained Recurrent Spontaneous Abortion during Early Pregnancy with the Qing Yi Tiao Mian Formula</atitle><jtitle>Explore (New York, N.Y.)</jtitle><addtitle>Explore (NY)</addtitle><date>2023-01</date><risdate>2023</risdate><volume>19</volume><issue>1</issue><spage>52</spage><epage>57</epage><pages>52-57</pages><issn>1550-8307</issn><eissn>1878-7541</eissn><abstract>•The aim of the present study was to analyze the clinical effect of Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and on the immune balance of T lymphocytes.•45 patients with URSA in 4th-9th week of pregnancy were separated into three groups: conventional fetal protection group (n=15), prednisone treatment group (n=10) and QYTM formula treatment group (n=20). These patients would get the treatment once they were diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (an injection of 20 ∼ 40 mg daily) for four weeks. The prednisone treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) +prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (an injection of 20 ∼ 40 mg daily) + QYTM formula (one dose per day) for four weeks. In addition, the women who had previously had a normal pregnancy have been enrolled as a control group (n=18). The success rate of the pregnancy in the first trimester was observed in each group, and the proportion of T lymphocytes in the peripheral blood before and after treatment was recorded.•QYTM formula significantly decreased the spontaneous abortion rate in URSA patients during early pregnancy. The mechanism may be closely related to the inhibition of the proliferation of killer lymphocytes represented by CD8+T lymphocytes and natural killer (NK) cells. The present study aims to analyze the clinical effect of the Qing Yi Tiao Mian (QYTM) formula on unexplained recurrent spontaneous abortion (URSA) during early pregnancy and the immune balance of T lymphocytes. With their consent, 45 patients with URSA in weeks 4–9 of pregnancy were separated into three groups, i.e., the conventional fetal protection (n = 15), prednisone treatment (n = 10), and QYTM formula treatment (n = 20) groups. These patients received treatment once they had been diagnosed with an intrauterine pregnancy. The conventional fetal protection group was given progesterone (20 ∼ 40 mg daily injection) for four weeks. The prednisone treatment group was given progesterone (20 ∼ 40 mg daily injection) + prednisone (5 mg/d) for four weeks. The QYTM formula treatment group was given progesterone (20 ∼ 40 mg daily injection) + QYTM formula (one dose per day) for four weeks. In addition, women who had previously had a normal pregnancy were enrolled as a control group (n = 18). The success rate of the pregnancy in the first trimester was observed in each group, and the proportion of T lymphocytes in the peripheral blood before and after treatment was recorded. Among the 20 patients with URSA in the QYTM formula treatment group, 19 remained pregnant. Thus, the success rate during early pregnancy was 95%, which was significantly higher than the conventional fetal protection (53.33%) and prednisone treatment (70%) groups. The CD8+ T and natural killer (NK) cells population in the URSA groups was higher compared with the control group (P &lt; 0.01). The QYTM formula treatment significantly decreased the ratio of CD8+ T lymphocytes (P &lt; 0.01) and NK cells (P &lt; 0.01). The QYTM formula significantly decreased the spontaneous abortion rate in patients with URSA during early pregnancy. The mechanism may be closely related to the inhibition of the killer lymphocytes’ proliferation by CD8+ T lymphocytes and NK cells.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35397998</pmid><doi>10.1016/j.explore.2022.03.009</doi><tpages>6</tpages></addata></record>
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subjects Abortion, Habitual - drug therapy
CD8+ T lymphocyte
Female
Humans
Killer Cells, Natural
natural killer (NK) cells
Prednisone
Pregnancy
Progesterone - therapeutic use
Qing Yi Tiao Mian (QYTM) formula
Unexplained recurrent spontaneous abortion (URSA)
title Clinical Research into Treating Unexplained Recurrent Spontaneous Abortion during Early Pregnancy with the Qing Yi Tiao Mian Formula
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