Quantitative changes in iris vasculature and blood flow in patients with different refractive errors
Purpose To evaluate the association between microvascular changes in the iris and refractive errors. Methods A cross-sectional case study. Seventy eyes from 70 patients with refractive errors were enrolled. Iris microvasculature was analyzed using optical coherence tomography angiography (OCTA). We...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2022-09, Vol.260 (9), p.3123-3129 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Jia, Yanwen Xue, Wenwen Wang, Yulan Zhao, Liquan Zou, Haidong |
| description | Purpose
To evaluate the association between microvascular changes in the iris and refractive errors.
Methods
A cross-sectional case study. Seventy eyes from 70 patients with refractive errors were enrolled. Iris microvasculature was analyzed using optical coherence tomography angiography (OCTA). We divided the iris images into three regions and calculated the vessel area density (VAD) and vessel skeleton density (VSD) of the inner one-third, inner two-thirds, and the entirety of the iris.
Results
The VADs and VSDs of the different regions were significantly different. The VAD and VSD of the inner one-third of the iris were higher than those of the other regions. The iris blood vessels were denser near the pupil margin, and blood vessels from the iris root to the pupil edge were radially distributed. The VAD and VSD of patients with mild hyperopia and emmetropia were higher than those of patients with moderate and high myopia. As the spherical equivalent increased, the VAD and VSD of the iris increased. Neither age nor sex contributed to significant differences in VAD and VSD.
Conclusion
Quantitative changes in iris microvasculature may indicate the development of myopia. |
| doi_str_mv | 10.1007/s00417-022-05632-7 |
| format | Article |
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To evaluate the association between microvascular changes in the iris and refractive errors.
Methods
A cross-sectional case study. Seventy eyes from 70 patients with refractive errors were enrolled. Iris microvasculature was analyzed using optical coherence tomography angiography (OCTA). We divided the iris images into three regions and calculated the vessel area density (VAD) and vessel skeleton density (VSD) of the inner one-third, inner two-thirds, and the entirety of the iris.
Results
The VADs and VSDs of the different regions were significantly different. The VAD and VSD of the inner one-third of the iris were higher than those of the other regions. The iris blood vessels were denser near the pupil margin, and blood vessels from the iris root to the pupil edge were radially distributed. The VAD and VSD of patients with mild hyperopia and emmetropia were higher than those of patients with moderate and high myopia. As the spherical equivalent increased, the VAD and VSD of the iris increased. Neither age nor sex contributed to significant differences in VAD and VSD.
Conclusion
Quantitative changes in iris microvasculature may indicate the development of myopia.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-022-05632-7</identifier><identifier>PMID: 35403868</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Angiography ; Blood flow ; Blood vessels ; Iris ; Low Vision ; Medicine ; Medicine & Public Health ; Microvasculature ; Myopia ; Ophthalmology</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2022-09, Vol.260 (9), p.3123-3129</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-561870d63b0e67ecec0e8cfcc91a509a263926defa7de6e596ae7eb03f8327f33</citedby><cites>FETCH-LOGICAL-c375t-561870d63b0e67ecec0e8cfcc91a509a263926defa7de6e596ae7eb03f8327f33</cites><orcidid>0000-0002-6831-7560</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-022-05632-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-022-05632-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35403868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Yanwen</creatorcontrib><creatorcontrib>Xue, Wenwen</creatorcontrib><creatorcontrib>Wang, Yulan</creatorcontrib><creatorcontrib>Zhao, Liquan</creatorcontrib><creatorcontrib>Zou, Haidong</creatorcontrib><title>Quantitative changes in iris vasculature and blood flow in patients with different refractive errors</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To evaluate the association between microvascular changes in the iris and refractive errors.
Methods
A cross-sectional case study. Seventy eyes from 70 patients with refractive errors were enrolled. Iris microvasculature was analyzed using optical coherence tomography angiography (OCTA). We divided the iris images into three regions and calculated the vessel area density (VAD) and vessel skeleton density (VSD) of the inner one-third, inner two-thirds, and the entirety of the iris.
Results
The VADs and VSDs of the different regions were significantly different. The VAD and VSD of the inner one-third of the iris were higher than those of the other regions. The iris blood vessels were denser near the pupil margin, and blood vessels from the iris root to the pupil edge were radially distributed. The VAD and VSD of patients with mild hyperopia and emmetropia were higher than those of patients with moderate and high myopia. As the spherical equivalent increased, the VAD and VSD of the iris increased. Neither age nor sex contributed to significant differences in VAD and VSD.
Conclusion
Quantitative changes in iris microvasculature may indicate the development of myopia.</description><subject>Angiography</subject><subject>Blood flow</subject><subject>Blood vessels</subject><subject>Iris</subject><subject>Low Vision</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Myopia</subject><subject>Ophthalmology</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtLAzEUhYMoWh9_wIUE3LgZvUmaZGYp4gsEERTchTRzYyPTmZrMVPz3prYquHAVLvnOuY9DyCGDUwagzxLAmOkCOC9AKsELvUFGbCxkoYE_b5IRaM6KUvDnHbKb0itkXki2TXaEHIMoVTki9cNg2z70tg8LpG5q2xdMNLQ0xJDowiY3NLYfIlLb1nTSdF1NfdO9L5F5FmHbJ_oe-imtg_cYc00j-mjdlyHG2MW0T7a8bRIerN898nR1-XhxU9zdX99enN8VTmjZF1KxUkOtxARQaXToAEvnnauYlVBZrkTFVY3e6hoVykpZ1DgB4fOO2guxR05WvvPYvQ2YejMLyWHT2Ba7IRmuxhWXTMkqo8d_0NduiG2eznANqiqV0EtDvqJc7FLKe5l5DDMbPwwDs8zArDIwOQPzlYHRWXS0th4mM6x_JN9Hz4BYASl_5XvH397_2H4CZKGTTg</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Jia, Yanwen</creator><creator>Xue, Wenwen</creator><creator>Wang, Yulan</creator><creator>Zhao, Liquan</creator><creator>Zou, Haidong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6831-7560</orcidid></search><sort><creationdate>20220901</creationdate><title>Quantitative changes in iris vasculature and blood flow in patients with different refractive errors</title><author>Jia, Yanwen ; Xue, Wenwen ; Wang, Yulan ; Zhao, Liquan ; Zou, Haidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-561870d63b0e67ecec0e8cfcc91a509a263926defa7de6e596ae7eb03f8327f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiography</topic><topic>Blood flow</topic><topic>Blood vessels</topic><topic>Iris</topic><topic>Low Vision</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Myopia</topic><topic>Ophthalmology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Yanwen</creatorcontrib><creatorcontrib>Xue, Wenwen</creatorcontrib><creatorcontrib>Wang, Yulan</creatorcontrib><creatorcontrib>Zhao, Liquan</creatorcontrib><creatorcontrib>Zou, Haidong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Yanwen</au><au>Xue, Wenwen</au><au>Wang, Yulan</au><au>Zhao, Liquan</au><au>Zou, Haidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative changes in iris vasculature and blood flow in patients with different refractive errors</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>260</volume><issue>9</issue><spage>3123</spage><epage>3129</epage><pages>3123-3129</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To evaluate the association between microvascular changes in the iris and refractive errors.
Methods
A cross-sectional case study. Seventy eyes from 70 patients with refractive errors were enrolled. Iris microvasculature was analyzed using optical coherence tomography angiography (OCTA). We divided the iris images into three regions and calculated the vessel area density (VAD) and vessel skeleton density (VSD) of the inner one-third, inner two-thirds, and the entirety of the iris.
Results
The VADs and VSDs of the different regions were significantly different. The VAD and VSD of the inner one-third of the iris were higher than those of the other regions. The iris blood vessels were denser near the pupil margin, and blood vessels from the iris root to the pupil edge were radially distributed. The VAD and VSD of patients with mild hyperopia and emmetropia were higher than those of patients with moderate and high myopia. As the spherical equivalent increased, the VAD and VSD of the iris increased. Neither age nor sex contributed to significant differences in VAD and VSD.
Conclusion
Quantitative changes in iris microvasculature may indicate the development of myopia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35403868</pmid><doi>10.1007/s00417-022-05632-7</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6831-7560</orcidid></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Angiography Blood flow Blood vessels Iris Low Vision Medicine Medicine & Public Health Microvasculature Myopia Ophthalmology |
| title | Quantitative changes in iris vasculature and blood flow in patients with different refractive errors |
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