Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity

The Mycobacterium tuberculosis tyrosine‐specific phosphatase MptpA and its cognate kinase PtkA are prospective targets for anti‐tuberculosis drugs as they interact with the host defense response within the macrophages. Although both are structurally well‐characterized, the functional mechanism regul...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	FEBS letters 2022-06, Vol.596 (12), p.1503-1515
Hauptverfasser:	Niesteruk, Anna, Sreeramulu, Sridhar, Jonker, Hendrik R. A., Richter, Christian, Schwalbe, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	cysteine‐redox regulation Mycobacterium tuberculosis nuclear magnetic resonance spectroscopy protein oxidation protein tyrosine phosphatase reactive oxygen species
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!