Mediterranean diet and other dietary patterns in association with biological aging in the Moli-sani Study cohort
Biological age (BA) is the hypothetical underlying age of an organism and has been proposed as a more powerful predictor of health than chronological age (CA). The difference between BA and CA (Δage) reflects the rate of biological aging, with lower values indicating slowed-down aging. We sought to...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2022-05, Vol.41 (5), p.1025-1033 |
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| creator | Esposito, Simona Gialluisi, Alessandro Costanzo, Simona Di Castelnuovo, Augusto Ruggiero, Emilia De Curtis, Amalia Persichillo, Mariarosaria Cerletti, Chiara Donati, Maria Benedetta de Gaetano, Giovanni Iacoviello, Licia Bonaccio, Marialaura Iacoviello, Licia de Gaetano, Giovanni Donati, Maria Benedetta Bonaccio, Marialaura Bonanni, Americo Cerletti, Chiara Costanzo, Simona De Curtis, Amalia Di Castelnuovo, Augusto Gianfagna, Francesco Persichillo, Mariarosaria Di Prospero, Teresa Vermylen, Jos De Paula Carrasco, Ignacio Spagnuolo, Antonio Assanelli, Deodato Centritto, Vincenzo Costanzo, Simona Olivieri, Marco Panzera, Teresa Di Castelnuovo, Augusto Bonaccio, Marialaura Costanzo, Simona Esposito, Simona Gialluisi, Alessandro Gianfagna, Francesco Ruggiero, Emilia De Curtis, Amalia Magnacca, Sara Izzi, Benedetta Marotta, Annalisa Noro, Fabrizia Parisi, Roberta Tirozzi, Alfonsina Persichillo, Mariarosaria Bracone, Francesca De Lucia, Francesca Mignogna, Cristiana Panzera, Teresa Rago, Livia Bonanni, Americo Direzione Generale per la Salute - Regione Molise Azienda Sanitaria Regionale del Molise Molise Dati Spa Offices of vital statistics of the Molise region Ospedale A. Cardarelli – Campobasso Ospedale F. Veneziale – Isernia Ospedale San Timoteo - Termoli (CB) Ospedale Ss. Rosario - Venafro (IS) Ospedale Vietri – Larino (CB) Ospedale San Francesco Caracciolo - Agnone (IS) Casa di Cura Villa Maria - Campobasso Ospedale Gemelli Molise - Campobasso IRCCS Neuromed - Pozzilli (IS) |
| description | Biological age (BA) is the hypothetical underlying age of an organism and has been proposed as a more powerful predictor of health than chronological age (CA). The difference between BA and CA (Δage) reflects the rate of biological aging, with lower values indicating slowed-down aging. We sought to compare the relationship of four a priori–defined dietary patterns, including a traditional Mediterranean diet (MD) and three non-Mediterranean diets, with biological aging (Δage) among Italian adults. We also examined distinctive nutritional traits of these diets as potential mediators of such associations.
Cross-sectional analysis on a sub-cohort of 4510 subjects (aged ≥35 y; 52.0% women) from the Moli-sani Study (enrolment, 2005–2010). Food intake was recorded by a 188-item semi-quantitative food-frequency questionnaire. A Mediterranean diet score (MDS) was used as exposure and compared with non-Mediterranean dietary patterns, i.e. DASH (Dietary Approaches to Stop Hypertension), Palaeolithic and the Nordic diets. A Deep Neural Network based on 36 blood biomarkers was used to compute BA and the resulting Δage (BA-CA), which was tested as outcome in multivariable linear regressions adjusted for clinical factors, lifestyles and sociodemographic factors.
In a multivariable-adjusted model, 1 standard deviation increase in the MDS was inversely associated with Δage (β = −0.23; 95%CI -0.40, −0.07), and similar findings were observed with the DASH diet (β = −0.17; 95%CI -0.33, −0.01). High dietary polyphenol content explained 29.8% (p = 0.04) and 65.8% (p = 0.02) of these associations, respectively, while other nutritional factors analysed (e.g. dietary fibre) were unlikely to be on the pathway. No significant associations were found with either the Palaeolithic or the Nordic diets.
Increasing adherence to either the traditional MD or the DASH diet was associated with delayed biological aging, possibly through their high polyphenol content. |
| doi_str_mv | 10.1016/j.clnu.2022.02.023 |
| format | Article |
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Cardarelli – Campobasso ; Ospedale F. Veneziale – Isernia ; Ospedale San Timoteo - Termoli (CB) ; Ospedale Ss. Rosario - Venafro (IS) ; Ospedale Vietri – Larino (CB) ; Ospedale San Francesco Caracciolo - Agnone (IS) ; Casa di Cura Villa Maria - Campobasso ; Ospedale Gemelli Molise - Campobasso ; IRCCS Neuromed - Pozzilli (IS)</creator><creatorcontrib>Esposito, Simona ; Gialluisi, Alessandro ; Costanzo, Simona ; Di Castelnuovo, Augusto ; Ruggiero, Emilia ; De Curtis, Amalia ; Persichillo, Mariarosaria ; Cerletti, Chiara ; Donati, Maria Benedetta ; de Gaetano, Giovanni ; Iacoviello, Licia ; Bonaccio, Marialaura ; Iacoviello, Licia ; de Gaetano, Giovanni ; Donati, Maria Benedetta ; Bonaccio, Marialaura ; Bonanni, Americo ; Cerletti, Chiara ; Costanzo, Simona ; De Curtis, Amalia ; Di Castelnuovo, Augusto ; Gianfagna, Francesco ; Persichillo, Mariarosaria ; Di Prospero, Teresa ; Vermylen, Jos ; De Paula Carrasco, Ignacio ; Spagnuolo, Antonio ; Assanelli, Deodato ; Centritto, Vincenzo ; Costanzo, Simona ; Olivieri, Marco ; Panzera, Teresa ; Di Castelnuovo, Augusto ; Bonaccio, Marialaura ; Costanzo, Simona ; Esposito, Simona ; Gialluisi, Alessandro ; Gianfagna, Francesco ; Ruggiero, Emilia ; De Curtis, Amalia ; Magnacca, Sara ; Izzi, Benedetta ; Marotta, Annalisa ; Noro, Fabrizia ; Parisi, Roberta ; Tirozzi, Alfonsina ; Persichillo, Mariarosaria ; Bracone, Francesca ; De Lucia, Francesca ; Mignogna, Cristiana ; Panzera, Teresa ; Rago, Livia ; Bonanni, Americo ; Direzione Generale per la Salute - Regione Molise ; Azienda Sanitaria Regionale del Molise ; Molise Dati Spa ; Offices of vital statistics of the Molise region ; Ospedale A. Cardarelli – Campobasso ; Ospedale F. Veneziale – Isernia ; Ospedale San Timoteo - Termoli (CB) ; Ospedale Ss. Rosario - Venafro (IS) ; Ospedale Vietri – Larino (CB) ; Ospedale San Francesco Caracciolo - Agnone (IS) ; Casa di Cura Villa Maria - Campobasso ; Ospedale Gemelli Molise - Campobasso ; IRCCS Neuromed - Pozzilli (IS) ; Moli-sani Study Investigators</creatorcontrib><description>Biological age (BA) is the hypothetical underlying age of an organism and has been proposed as a more powerful predictor of health than chronological age (CA). The difference between BA and CA (Δage) reflects the rate of biological aging, with lower values indicating slowed-down aging. We sought to compare the relationship of four a priori–defined dietary patterns, including a traditional Mediterranean diet (MD) and three non-Mediterranean diets, with biological aging (Δage) among Italian adults. We also examined distinctive nutritional traits of these diets as potential mediators of such associations.
Cross-sectional analysis on a sub-cohort of 4510 subjects (aged ≥35 y; 52.0% women) from the Moli-sani Study (enrolment, 2005–2010). Food intake was recorded by a 188-item semi-quantitative food-frequency questionnaire. A Mediterranean diet score (MDS) was used as exposure and compared with non-Mediterranean dietary patterns, i.e. DASH (Dietary Approaches to Stop Hypertension), Palaeolithic and the Nordic diets. A Deep Neural Network based on 36 blood biomarkers was used to compute BA and the resulting Δage (BA-CA), which was tested as outcome in multivariable linear regressions adjusted for clinical factors, lifestyles and sociodemographic factors.
In a multivariable-adjusted model, 1 standard deviation increase in the MDS was inversely associated with Δage (β = −0.23; 95%CI -0.40, −0.07), and similar findings were observed with the DASH diet (β = −0.17; 95%CI -0.33, −0.01). High dietary polyphenol content explained 29.8% (p = 0.04) and 65.8% (p = 0.02) of these associations, respectively, while other nutritional factors analysed (e.g. dietary fibre) were unlikely to be on the pathway. No significant associations were found with either the Palaeolithic or the Nordic diets.
Increasing adherence to either the traditional MD or the DASH diet was associated with delayed biological aging, possibly through their high polyphenol content.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2022.02.023</identifier><identifier>PMID: 35390726</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aging ; Biological aging ; Cohort Studies ; Cross-Sectional Studies ; Dash diet ; Diet ; Diet, Mediterranean ; Female ; Humans ; Male ; Mediterranean diet ; Nordic diet ; Palaeolithic diet ; Polyphenols</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2022-05, Vol.41 (5), p.1025-1033</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-a410d87eecbddc0c3cbb30a07d013d217d1d0d152253181a250976be5bcd4043</citedby><cites>FETCH-LOGICAL-c356t-a410d87eecbddc0c3cbb30a07d013d217d1d0d152253181a250976be5bcd4043</cites><orcidid>0000-0002-7109-1128 ; 0000-0003-1747-5443 ; 0000-0002-7823-1402 ; 0000-0002-9731-0173 ; 0000-0002-4759-3179 ; 0000-0003-0514-5885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0261561422000747$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35390726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esposito, Simona</creatorcontrib><creatorcontrib>Gialluisi, Alessandro</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>Di Castelnuovo, Augusto</creatorcontrib><creatorcontrib>Ruggiero, Emilia</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Persichillo, Mariarosaria</creatorcontrib><creatorcontrib>Cerletti, Chiara</creatorcontrib><creatorcontrib>Donati, Maria Benedetta</creatorcontrib><creatorcontrib>de Gaetano, Giovanni</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>Bonaccio, Marialaura</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>de Gaetano, Giovanni</creatorcontrib><creatorcontrib>Donati, Maria Benedetta</creatorcontrib><creatorcontrib>Bonaccio, Marialaura</creatorcontrib><creatorcontrib>Bonanni, Americo</creatorcontrib><creatorcontrib>Cerletti, Chiara</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Di Castelnuovo, Augusto</creatorcontrib><creatorcontrib>Gianfagna, Francesco</creatorcontrib><creatorcontrib>Persichillo, Mariarosaria</creatorcontrib><creatorcontrib>Di Prospero, Teresa</creatorcontrib><creatorcontrib>Vermylen, Jos</creatorcontrib><creatorcontrib>De Paula Carrasco, Ignacio</creatorcontrib><creatorcontrib>Spagnuolo, Antonio</creatorcontrib><creatorcontrib>Assanelli, Deodato</creatorcontrib><creatorcontrib>Centritto, Vincenzo</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>Olivieri, Marco</creatorcontrib><creatorcontrib>Panzera, Teresa</creatorcontrib><creatorcontrib>Di Castelnuovo, Augusto</creatorcontrib><creatorcontrib>Bonaccio, Marialaura</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>Esposito, Simona</creatorcontrib><creatorcontrib>Gialluisi, Alessandro</creatorcontrib><creatorcontrib>Gianfagna, Francesco</creatorcontrib><creatorcontrib>Ruggiero, Emilia</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Magnacca, Sara</creatorcontrib><creatorcontrib>Izzi, Benedetta</creatorcontrib><creatorcontrib>Marotta, Annalisa</creatorcontrib><creatorcontrib>Noro, Fabrizia</creatorcontrib><creatorcontrib>Parisi, Roberta</creatorcontrib><creatorcontrib>Tirozzi, Alfonsina</creatorcontrib><creatorcontrib>Persichillo, Mariarosaria</creatorcontrib><creatorcontrib>Bracone, Francesca</creatorcontrib><creatorcontrib>De Lucia, Francesca</creatorcontrib><creatorcontrib>Mignogna, Cristiana</creatorcontrib><creatorcontrib>Panzera, Teresa</creatorcontrib><creatorcontrib>Rago, Livia</creatorcontrib><creatorcontrib>Bonanni, Americo</creatorcontrib><creatorcontrib>Direzione Generale per la Salute - Regione Molise</creatorcontrib><creatorcontrib>Azienda Sanitaria Regionale del Molise</creatorcontrib><creatorcontrib>Molise Dati Spa</creatorcontrib><creatorcontrib>Offices of vital statistics of the Molise region</creatorcontrib><creatorcontrib>Ospedale A. Cardarelli – Campobasso</creatorcontrib><creatorcontrib>Ospedale F. Veneziale – Isernia</creatorcontrib><creatorcontrib>Ospedale San Timoteo - Termoli (CB)</creatorcontrib><creatorcontrib>Ospedale Ss. Rosario - Venafro (IS)</creatorcontrib><creatorcontrib>Ospedale Vietri – Larino (CB)</creatorcontrib><creatorcontrib>Ospedale San Francesco Caracciolo - Agnone (IS)</creatorcontrib><creatorcontrib>Casa di Cura Villa Maria - Campobasso</creatorcontrib><creatorcontrib>Ospedale Gemelli Molise - Campobasso</creatorcontrib><creatorcontrib>IRCCS Neuromed - Pozzilli (IS)</creatorcontrib><creatorcontrib>Moli-sani Study Investigators</creatorcontrib><title>Mediterranean diet and other dietary patterns in association with biological aging in the Moli-sani Study cohort</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Biological age (BA) is the hypothetical underlying age of an organism and has been proposed as a more powerful predictor of health than chronological age (CA). The difference between BA and CA (Δage) reflects the rate of biological aging, with lower values indicating slowed-down aging. We sought to compare the relationship of four a priori–defined dietary patterns, including a traditional Mediterranean diet (MD) and three non-Mediterranean diets, with biological aging (Δage) among Italian adults. We also examined distinctive nutritional traits of these diets as potential mediators of such associations.
Cross-sectional analysis on a sub-cohort of 4510 subjects (aged ≥35 y; 52.0% women) from the Moli-sani Study (enrolment, 2005–2010). Food intake was recorded by a 188-item semi-quantitative food-frequency questionnaire. A Mediterranean diet score (MDS) was used as exposure and compared with non-Mediterranean dietary patterns, i.e. DASH (Dietary Approaches to Stop Hypertension), Palaeolithic and the Nordic diets. A Deep Neural Network based on 36 blood biomarkers was used to compute BA and the resulting Δage (BA-CA), which was tested as outcome in multivariable linear regressions adjusted for clinical factors, lifestyles and sociodemographic factors.
In a multivariable-adjusted model, 1 standard deviation increase in the MDS was inversely associated with Δage (β = −0.23; 95%CI -0.40, −0.07), and similar findings were observed with the DASH diet (β = −0.17; 95%CI -0.33, −0.01). High dietary polyphenol content explained 29.8% (p = 0.04) and 65.8% (p = 0.02) of these associations, respectively, while other nutritional factors analysed (e.g. dietary fibre) were unlikely to be on the pathway. No significant associations were found with either the Palaeolithic or the Nordic diets.
Increasing adherence to either the traditional MD or the DASH diet was associated with delayed biological aging, possibly through their high polyphenol content.</description><subject>Adult</subject><subject>Aging</subject><subject>Biological aging</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Dash diet</subject><subject>Diet</subject><subject>Diet, Mediterranean</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mediterranean diet</subject><subject>Nordic diet</subject><subject>Palaeolithic diet</subject><subject>Polyphenols</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEURUVoady0P9BF0bKbcZ-k0cwYugkmSQM2XTR7oZFebJmx5EqaBP99NLGTZeGBEJx74R5CvjGYM2DNz93cDH6cc-B8DtOJCzJjUvCKLTrxgcyAN6ySDasvyeeUdgAgRdt9IpdCigW0vJmRwxqtyxij9qg9tQ4z1d7SkLcYX786HulB58L4RJ2nOqVgnM4uePrs8pb2Lgxh44weqN44v5mgkqbrMLgqae_o3zzaIzVhG2L-Qj4-6iHh1_N7RR5ubx6Wv6vVn7v75fWqMkI2udI1A9u1iKa31oARpu8FaGgtMGE5ay2zYJnkXArWMc0lLNqmR9kbW0MtrsiPU-0hhn8jpqz2LhkchrIzjEnxpu66Rdc1UFB-Qk0MKUV8VIfo9mW2YqAm0WqnJtFqEq1gOlFC38_9Y79H-x55M1uAXycAy8gnh1El49CbojuiycoG97_-F5jQkJs</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Esposito, Simona</creator><creator>Gialluisi, Alessandro</creator><creator>Costanzo, Simona</creator><creator>Di Castelnuovo, Augusto</creator><creator>Ruggiero, Emilia</creator><creator>De Curtis, Amalia</creator><creator>Persichillo, Mariarosaria</creator><creator>Cerletti, Chiara</creator><creator>Donati, Maria Benedetta</creator><creator>de Gaetano, Giovanni</creator><creator>Iacoviello, Licia</creator><creator>Bonaccio, Marialaura</creator><creator>Iacoviello, Licia</creator><creator>de Gaetano, Giovanni</creator><creator>Donati, Maria Benedetta</creator><creator>Bonaccio, Marialaura</creator><creator>Bonanni, Americo</creator><creator>Cerletti, Chiara</creator><creator>Costanzo, Simona</creator><creator>De Curtis, Amalia</creator><creator>Di Castelnuovo, Augusto</creator><creator>Gianfagna, Francesco</creator><creator>Persichillo, Mariarosaria</creator><creator>Di Prospero, Teresa</creator><creator>Vermylen, Jos</creator><creator>De Paula Carrasco, Ignacio</creator><creator>Spagnuolo, Antonio</creator><creator>Assanelli, Deodato</creator><creator>Centritto, Vincenzo</creator><creator>Costanzo, Simona</creator><creator>Olivieri, Marco</creator><creator>Panzera, Teresa</creator><creator>Di Castelnuovo, Augusto</creator><creator>Bonaccio, Marialaura</creator><creator>Costanzo, Simona</creator><creator>Esposito, Simona</creator><creator>Gialluisi, Alessandro</creator><creator>Gianfagna, Francesco</creator><creator>Ruggiero, Emilia</creator><creator>De Curtis, Amalia</creator><creator>Magnacca, Sara</creator><creator>Izzi, Benedetta</creator><creator>Marotta, Annalisa</creator><creator>Noro, Fabrizia</creator><creator>Parisi, Roberta</creator><creator>Tirozzi, Alfonsina</creator><creator>Persichillo, Mariarosaria</creator><creator>Bracone, Francesca</creator><creator>De Lucia, Francesca</creator><creator>Mignogna, Cristiana</creator><creator>Panzera, Teresa</creator><creator>Rago, Livia</creator><creator>Bonanni, Americo</creator><creator>Direzione Generale per la Salute - Regione Molise</creator><creator>Azienda Sanitaria Regionale del Molise</creator><creator>Molise Dati Spa</creator><creator>Offices of vital statistics of the Molise region</creator><creator>Ospedale A. 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Cardarelli – Campobasso ; Ospedale F. Veneziale – Isernia ; Ospedale San Timoteo - Termoli (CB) ; Ospedale Ss. Rosario - Venafro (IS) ; Ospedale Vietri – Larino (CB) ; Ospedale San Francesco Caracciolo - Agnone (IS) ; Casa di Cura Villa Maria - Campobasso ; Ospedale Gemelli Molise - Campobasso ; IRCCS Neuromed - Pozzilli (IS)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-a410d87eecbddc0c3cbb30a07d013d217d1d0d152253181a250976be5bcd4043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aging</topic><topic>Biological aging</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Dash diet</topic><topic>Diet</topic><topic>Diet, Mediterranean</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mediterranean diet</topic><topic>Nordic diet</topic><topic>Palaeolithic diet</topic><topic>Polyphenols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esposito, Simona</creatorcontrib><creatorcontrib>Gialluisi, Alessandro</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>Di Castelnuovo, Augusto</creatorcontrib><creatorcontrib>Ruggiero, Emilia</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Persichillo, Mariarosaria</creatorcontrib><creatorcontrib>Cerletti, Chiara</creatorcontrib><creatorcontrib>Donati, Maria Benedetta</creatorcontrib><creatorcontrib>de Gaetano, Giovanni</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>Bonaccio, Marialaura</creatorcontrib><creatorcontrib>Iacoviello, Licia</creatorcontrib><creatorcontrib>de Gaetano, Giovanni</creatorcontrib><creatorcontrib>Donati, Maria Benedetta</creatorcontrib><creatorcontrib>Bonaccio, Marialaura</creatorcontrib><creatorcontrib>Bonanni, Americo</creatorcontrib><creatorcontrib>Cerletti, Chiara</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Di Castelnuovo, Augusto</creatorcontrib><creatorcontrib>Gianfagna, Francesco</creatorcontrib><creatorcontrib>Persichillo, Mariarosaria</creatorcontrib><creatorcontrib>Di Prospero, Teresa</creatorcontrib><creatorcontrib>Vermylen, Jos</creatorcontrib><creatorcontrib>De Paula Carrasco, Ignacio</creatorcontrib><creatorcontrib>Spagnuolo, Antonio</creatorcontrib><creatorcontrib>Assanelli, Deodato</creatorcontrib><creatorcontrib>Centritto, Vincenzo</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>Olivieri, Marco</creatorcontrib><creatorcontrib>Panzera, Teresa</creatorcontrib><creatorcontrib>Di Castelnuovo, Augusto</creatorcontrib><creatorcontrib>Bonaccio, Marialaura</creatorcontrib><creatorcontrib>Costanzo, Simona</creatorcontrib><creatorcontrib>Esposito, Simona</creatorcontrib><creatorcontrib>Gialluisi, Alessandro</creatorcontrib><creatorcontrib>Gianfagna, Francesco</creatorcontrib><creatorcontrib>Ruggiero, Emilia</creatorcontrib><creatorcontrib>De Curtis, Amalia</creatorcontrib><creatorcontrib>Magnacca, Sara</creatorcontrib><creatorcontrib>Izzi, Benedetta</creatorcontrib><creatorcontrib>Marotta, Annalisa</creatorcontrib><creatorcontrib>Noro, Fabrizia</creatorcontrib><creatorcontrib>Parisi, Roberta</creatorcontrib><creatorcontrib>Tirozzi, Alfonsina</creatorcontrib><creatorcontrib>Persichillo, Mariarosaria</creatorcontrib><creatorcontrib>Bracone, Francesca</creatorcontrib><creatorcontrib>De Lucia, Francesca</creatorcontrib><creatorcontrib>Mignogna, Cristiana</creatorcontrib><creatorcontrib>Panzera, Teresa</creatorcontrib><creatorcontrib>Rago, Livia</creatorcontrib><creatorcontrib>Bonanni, Americo</creatorcontrib><creatorcontrib>Direzione Generale per la Salute - Regione Molise</creatorcontrib><creatorcontrib>Azienda Sanitaria Regionale del Molise</creatorcontrib><creatorcontrib>Molise Dati Spa</creatorcontrib><creatorcontrib>Offices of vital statistics of the Molise region</creatorcontrib><creatorcontrib>Ospedale A. Cardarelli – Campobasso</creatorcontrib><creatorcontrib>Ospedale F. Veneziale – Isernia</creatorcontrib><creatorcontrib>Ospedale San Timoteo - Termoli (CB)</creatorcontrib><creatorcontrib>Ospedale Ss. Rosario - Venafro (IS)</creatorcontrib><creatorcontrib>Ospedale Vietri – Larino (CB)</creatorcontrib><creatorcontrib>Ospedale San Francesco Caracciolo - Agnone (IS)</creatorcontrib><creatorcontrib>Casa di Cura Villa Maria - Campobasso</creatorcontrib><creatorcontrib>Ospedale Gemelli Molise - Campobasso</creatorcontrib><creatorcontrib>IRCCS Neuromed - Pozzilli (IS)</creatorcontrib><creatorcontrib>Moli-sani Study Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Esposito, Simona</au><au>Gialluisi, Alessandro</au><au>Costanzo, Simona</au><au>Di Castelnuovo, Augusto</au><au>Ruggiero, Emilia</au><au>De Curtis, Amalia</au><au>Persichillo, Mariarosaria</au><au>Cerletti, Chiara</au><au>Donati, Maria Benedetta</au><au>de Gaetano, Giovanni</au><au>Iacoviello, Licia</au><au>Bonaccio, Marialaura</au><au>Iacoviello, Licia</au><au>de Gaetano, Giovanni</au><au>Donati, Maria Benedetta</au><au>Bonaccio, Marialaura</au><au>Bonanni, Americo</au><au>Cerletti, Chiara</au><au>Costanzo, Simona</au><au>De Curtis, Amalia</au><au>Di Castelnuovo, Augusto</au><au>Gianfagna, Francesco</au><au>Persichillo, Mariarosaria</au><au>Di Prospero, Teresa</au><au>Vermylen, Jos</au><au>De Paula Carrasco, Ignacio</au><au>Spagnuolo, Antonio</au><au>Assanelli, Deodato</au><au>Centritto, Vincenzo</au><au>Costanzo, Simona</au><au>Olivieri, Marco</au><au>Panzera, Teresa</au><au>Di Castelnuovo, Augusto</au><au>Bonaccio, Marialaura</au><au>Costanzo, Simona</au><au>Esposito, Simona</au><au>Gialluisi, Alessandro</au><au>Gianfagna, Francesco</au><au>Ruggiero, Emilia</au><au>De Curtis, Amalia</au><au>Magnacca, Sara</au><au>Izzi, Benedetta</au><au>Marotta, Annalisa</au><au>Noro, Fabrizia</au><au>Parisi, Roberta</au><au>Tirozzi, Alfonsina</au><au>Persichillo, Mariarosaria</au><au>Bracone, Francesca</au><au>De Lucia, Francesca</au><au>Mignogna, Cristiana</au><au>Panzera, Teresa</au><au>Rago, Livia</au><au>Bonanni, Americo</au><au>Direzione Generale per la Salute - Regione Molise</au><au>Azienda Sanitaria Regionale del Molise</au><au>Molise Dati Spa</au><au>Offices of vital statistics of the Molise region</au><au>Ospedale A. Cardarelli – Campobasso</au><au>Ospedale F. Veneziale – Isernia</au><au>Ospedale San Timoteo - Termoli (CB)</au><au>Ospedale Ss. Rosario - Venafro (IS)</au><au>Ospedale Vietri – Larino (CB)</au><au>Ospedale San Francesco Caracciolo - Agnone (IS)</au><au>Casa di Cura Villa Maria - Campobasso</au><au>Ospedale Gemelli Molise - Campobasso</au><au>IRCCS Neuromed - Pozzilli (IS)</au><aucorp>Moli-sani Study Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediterranean diet and other dietary patterns in association with biological aging in the Moli-sani Study cohort</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2022-05</date><risdate>2022</risdate><volume>41</volume><issue>5</issue><spage>1025</spage><epage>1033</epage><pages>1025-1033</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>Biological age (BA) is the hypothetical underlying age of an organism and has been proposed as a more powerful predictor of health than chronological age (CA). The difference between BA and CA (Δage) reflects the rate of biological aging, with lower values indicating slowed-down aging. We sought to compare the relationship of four a priori–defined dietary patterns, including a traditional Mediterranean diet (MD) and three non-Mediterranean diets, with biological aging (Δage) among Italian adults. We also examined distinctive nutritional traits of these diets as potential mediators of such associations.
Cross-sectional analysis on a sub-cohort of 4510 subjects (aged ≥35 y; 52.0% women) from the Moli-sani Study (enrolment, 2005–2010). Food intake was recorded by a 188-item semi-quantitative food-frequency questionnaire. A Mediterranean diet score (MDS) was used as exposure and compared with non-Mediterranean dietary patterns, i.e. DASH (Dietary Approaches to Stop Hypertension), Palaeolithic and the Nordic diets. A Deep Neural Network based on 36 blood biomarkers was used to compute BA and the resulting Δage (BA-CA), which was tested as outcome in multivariable linear regressions adjusted for clinical factors, lifestyles and sociodemographic factors.
In a multivariable-adjusted model, 1 standard deviation increase in the MDS was inversely associated with Δage (β = −0.23; 95%CI -0.40, −0.07), and similar findings were observed with the DASH diet (β = −0.17; 95%CI -0.33, −0.01). High dietary polyphenol content explained 29.8% (p = 0.04) and 65.8% (p = 0.02) of these associations, respectively, while other nutritional factors analysed (e.g. dietary fibre) were unlikely to be on the pathway. No significant associations were found with either the Palaeolithic or the Nordic diets.
Increasing adherence to either the traditional MD or the DASH diet was associated with delayed biological aging, possibly through their high polyphenol content.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35390726</pmid><doi>10.1016/j.clnu.2022.02.023</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7109-1128</orcidid><orcidid>https://orcid.org/0000-0003-1747-5443</orcidid><orcidid>https://orcid.org/0000-0002-7823-1402</orcidid><orcidid>https://orcid.org/0000-0002-9731-0173</orcidid><orcidid>https://orcid.org/0000-0002-4759-3179</orcidid><orcidid>https://orcid.org/0000-0003-0514-5885</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2022-05, Vol.41 (5), p.1025-1033 |
| issn | 0261-5614 1532-1983 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2648898860 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aging Biological aging Cohort Studies Cross-Sectional Studies Dash diet Diet Diet, Mediterranean Female Humans Male Mediterranean diet Nordic diet Palaeolithic diet Polyphenols |
| title | Mediterranean diet and other dietary patterns in association with biological aging in the Moli-sani Study cohort |
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