Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination

Pyroptosis is a recently discovered form of inflammatory programmed necrosis characterized by caspase-1-mediated and gasdermin D-dependent cell death leading to the release of pro-inflammatory cytokines such as Interleukin-1 beta (IL-1β). Here, we evaluated whether pyroptosis could be exploited in D...

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Veröffentlicht in:	Vaccine 2022-03, Vol.40 (13), p.2087-2098
Hauptverfasser:	Arakelian, Tsolere, Oosterhuis, Koen, Tondini, Elena, Los, Mandy, Vree, Jana, van Geldorp, Mariska, Camps, Marcel, Teunisse, Bram, Zoutendijk, Iris, Arens, Ramon, Zondag, Gerben, Ossendorp, Ferry, van Bergen, Jeroen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Animals Antigens Apoptosis Cancer Cancer immunotherapy Caspase 1 - metabolism Caspase-1 CD8 antigen CD8-positive T-lymphocytes Cell death Chemokines Cytokines Deoxyribonucleic acid DNA DNA vaccination DNA vaccines Epitopes IL-1β Immunization Immunotherapy Inflammation Interleukin 1 Interleukin-1beta Lymphocytes Lymphocytes T Melanoma Mice necroptosis Necrosis Ovalbumin Plasmids Pyroptosis recombinant vaccines Recruitment Transfection Vaccination Vaccines Vaccines, DNA
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