Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function

Targeting immune checkpoints such as programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has transformed cancer treatment, with durable clinical responses across a wide range of tumor types. However, a high percentage of patients fail to respond to anti-PD-1/PD-L1 treatment. A...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2022-06, Vol.82 (11), p.2185-2195
Hauptverfasser:	Zhao, Xixi, Wei, Yongkun, Chu, Yu-Yi, Li, Yintao, Hsu, Jung-Mao, Jiang, Zhou, Liu, Chunxiao, Hsu, Jennifer L, Chang, Wei-Chao, Yang, Riyao, Chan, Li-Chuan, Qu, Jingkun, Zhang, Shuqun, Ying, Haoqiang, Yu, Dihua, Hung, Mien-Chie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-H1 Antigen Casein Kinase II - metabolism Dendritic Cells - metabolism Hepatitis A Virus Cellular Receptor 2 - metabolism Humans Mice Neoplasms Phosphorylation Programmed Cell Death 1 Receptor - metabolism
Online-Zugang:	Volltext
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