Beyond the cyclopropyl ring formation: fungal Aj_EasH catalyzes asymmetric hydroxylation of ergot alkaloids

Ergot alkaloids (EAs) are among the most important bioactive natural products. Fe II / α -ketoglutarate-dependent dioxygenase Aj_EasH from Aspergillus japonicus is responsible for the formation of the cyclopropyl ring of the ergot alkaloid (EA) cycloclavine ( 4 ). Herein we reconstituted the biosynt...

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Veröffentlicht in:	Applied microbiology and biotechnology 2022-04, Vol.106 (8), p.2981-2991
Hauptverfasser:	An, Chunyan, Zhu, Fangfang, Yao, Yongpeng, Zhang, Kexin, Wang, Wei, Zhang, Jun, Wei, Guangzheng, Xia, Yue, Gao, Qiang, Gao, Shu-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Alpha-Ketoglutarate-Dependent Dioxygenase FTO Analysis Asymmetry Biological activity Biomedical and Life Sciences Biosynthesis Biotechnologically Relevant Enzymes and Proteins Biotechnology Cloning Dioxygenase Enzymes Ergot Ergot Alkaloids Ferrous Compounds Hydroxylation Identification and classification Ketoglutaric acid Laboratories Life Sciences Methods Microbial Genetics and Genomics Microbiology Molecular docking Molecular Docking Simulation Natural products NMR Nuclear magnetic resonance Organic compounds Properties Protein expression Structure Substrates
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