Circular RNA VMA21 ameliorates IL-1β-engendered chondrocyte injury through the miR-495-3p/FBWX7 signaling axis

This study explored the function of circular RNA VMA21 (circVMA21) in osteoarthritis (OA). IL-1β inducement reduced the expression of circVMA21 in C28/I2 cells and human primary chondrocytes. Forced expression of circVMA21 heightened cell viability and attenuated cell apoptosis, accompanied by upreg...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2022-05, Vol.238, p.108995-108995, Article 108995
Hauptverfasser:	Li, ZhiFu, Meng, DongDong, Liu, YongYi, Bi, FangGang, Tian, Ke, Xu, JianZhong, Sun, JianGuang, Gu, ChenXi, Li, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Chondrocytes - metabolism circVMA21 Extracellular matrix FBWX7 Interleukin-1beta - metabolism MicroRNAs - genetics MicroRNAs - metabolism miR-495-3p Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Rats RNA, Circular - genetics Signal Transduction
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