Direction and magnitude of displacement differ between slowly expanding and non-expanding multiple sclerosis lesions as compared to small vessel disease
Background and purpose Differentiating between multiple sclerosis (MS) and small vessel disease (SVD) lesions represents a key challenge in the day-to-day management of patients. We aimed to distinguish between MS and SVD by identifying the dynamics of lesion movement patterns between enlarging and...
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| Veröffentlicht in: | Journal of neurology 2022-08, Vol.269 (8), p.4459-4468 |
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| creator | Moog, Tatum M. McCreary, Morgan Wilson, Andrew Stanley, Thomas Yu, Fang F. Pinho, Marco Guo, Xiaohu Okuda, Darin T. |
| description | Background and purpose
Differentiating between multiple sclerosis (MS) and small vessel disease (SVD) lesions represents a key challenge in the day-to-day management of patients. We aimed to distinguish between MS and SVD by identifying the dynamics of lesion movement patterns between enlarging and contracting foci from two MRI time points.
Methods
Standardized 3-Tesla 3-dimensional brain magnetic resonance imaging (MRI) studies were performed at two time points on enrolled MS and SVD patients. Selected supratentorial lesions were segmented and longitudinal changes in the direction of lesion displacement and magnitude along with the evolution of contracting and expanding T1-weighted and T2-weighted MS lesions were quantified based on lesion centroid positioning. Bayesian linear mixed effects regression models were constructed to evaluate associations between changes in lesion transitions and disease state.
Results
A total of 420 lesions were analyzed from 35 MS (female (F):22 (62.9%); median age (range):38 years (y) (22–61), median disease duration:7.38y (0.38–20.99)) and 12 SVD patients (F:11 (100%); 54y (40–66)). MS T2-weighted lesions that increased in volume between MRI time points demonstrated movement toward the cortex (
p
= 0.01), whereas those that decreased in volume moved toward the center (
p
|
| doi_str_mv | 10.1007/s00415-022-11089-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2647211376</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2647211376</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-60f9ed213568f576c7bceb836a53cd12e77b600b64705cc54cc1cdcc8e2bb0093</originalsourceid><addsrcrecordid>eNp9kctu1TAQhi1ERQ-FF2CBLLFhEzq-5bJE5SpVYtOuI8eZHLly7OBJKH0THhefnkIlFmxsjef7_xnrZ-yVgHcCoDknAC1MBVJWQkDbVd0TthNalVKb7inbgdJQGWX0KXtOdAMAbWk8Y6fKqBak0Tv264PP6FafIrdx5LPdR79uI_I08dHTEqzDGeNaimnCzAdcbxEjp5Buwx3Hn0uR-bi_V8cUq8eXeQurXwJycgFzIk88IJVJxC1xl-bFZhz5mjjNNgT-A4kwHKaiJXzBTiYbCF8-3Gfs-tPHq4sv1eW3z18v3l9WTjVmrWqYOhylUKZuJ9PUrhkcDq2qrVFuFBKbZqgBhlo3YJwz2jnhRudalMMA0Kkz9vbou-T0fUNa-9mTwxBsxLRRL4tSCqGauqBv_kFv0pZj2a5QnZBal6NQ8ki58mfKOPVL9rPNd72A_pBbf8ytL7n197n1hy1eP1hvw4zjX8mfoAqgjgCVVtxjfpz9H9vfV1ambQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2691244912</pqid></control><display><type>article</type><title>Direction and magnitude of displacement differ between slowly expanding and non-expanding multiple sclerosis lesions as compared to small vessel disease</title><source>SpringerLink Journals</source><creator>Moog, Tatum M. ; McCreary, Morgan ; Wilson, Andrew ; Stanley, Thomas ; Yu, Fang F. ; Pinho, Marco ; Guo, Xiaohu ; Okuda, Darin T.</creator><creatorcontrib>Moog, Tatum M. ; McCreary, Morgan ; Wilson, Andrew ; Stanley, Thomas ; Yu, Fang F. ; Pinho, Marco ; Guo, Xiaohu ; Okuda, Darin T.</creatorcontrib><description>Background and purpose
Differentiating between multiple sclerosis (MS) and small vessel disease (SVD) lesions represents a key challenge in the day-to-day management of patients. We aimed to distinguish between MS and SVD by identifying the dynamics of lesion movement patterns between enlarging and contracting foci from two MRI time points.
Methods
Standardized 3-Tesla 3-dimensional brain magnetic resonance imaging (MRI) studies were performed at two time points on enrolled MS and SVD patients. Selected supratentorial lesions were segmented and longitudinal changes in the direction of lesion displacement and magnitude along with the evolution of contracting and expanding T1-weighted and T2-weighted MS lesions were quantified based on lesion centroid positioning. Bayesian linear mixed effects regression models were constructed to evaluate associations between changes in lesion transitions and disease state.
Results
A total of 420 lesions were analyzed from 35 MS (female (F):22 (62.9%); median age (range):38 years (y) (22–61), median disease duration:7.38y (0.38–20.99)) and 12 SVD patients (F:11 (100%); 54y (40–66)). MS T2-weighted lesions that increased in volume between MRI time points demonstrated movement toward the cortex (
p
= 0.01), whereas those that decreased in volume moved toward the center (
p
< 0.0001). Lesion volume changes related to SVD demonstrated no effect on movement direction over time. Both expanding (
p
= 0.03) and contracting (
p
= 0.01) MS lesions demonstrated greater distances between centroids when compared to SVD.
Conclusion
Lesion dynamics may reveal distinct characteristics associated with the biology of disease while providing further insights into the behavior of inflammatory CNS disorders.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-022-11089-9</identifier><identifier>PMID: 35380254</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bayesian analysis ; Lesions ; Magnetic resonance imaging ; Mathematical models ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Neuroimaging ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Regression analysis</subject><ispartof>Journal of neurology, 2022-08, Vol.269 (8), p.4459-4468</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-60f9ed213568f576c7bceb836a53cd12e77b600b64705cc54cc1cdcc8e2bb0093</citedby><cites>FETCH-LOGICAL-c375t-60f9ed213568f576c7bceb836a53cd12e77b600b64705cc54cc1cdcc8e2bb0093</cites><orcidid>0000-0002-6499-1523</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-022-11089-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-022-11089-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35380254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moog, Tatum M.</creatorcontrib><creatorcontrib>McCreary, Morgan</creatorcontrib><creatorcontrib>Wilson, Andrew</creatorcontrib><creatorcontrib>Stanley, Thomas</creatorcontrib><creatorcontrib>Yu, Fang F.</creatorcontrib><creatorcontrib>Pinho, Marco</creatorcontrib><creatorcontrib>Guo, Xiaohu</creatorcontrib><creatorcontrib>Okuda, Darin T.</creatorcontrib><title>Direction and magnitude of displacement differ between slowly expanding and non-expanding multiple sclerosis lesions as compared to small vessel disease</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background and purpose
Differentiating between multiple sclerosis (MS) and small vessel disease (SVD) lesions represents a key challenge in the day-to-day management of patients. We aimed to distinguish between MS and SVD by identifying the dynamics of lesion movement patterns between enlarging and contracting foci from two MRI time points.
Methods
Standardized 3-Tesla 3-dimensional brain magnetic resonance imaging (MRI) studies were performed at two time points on enrolled MS and SVD patients. Selected supratentorial lesions were segmented and longitudinal changes in the direction of lesion displacement and magnitude along with the evolution of contracting and expanding T1-weighted and T2-weighted MS lesions were quantified based on lesion centroid positioning. Bayesian linear mixed effects regression models were constructed to evaluate associations between changes in lesion transitions and disease state.
Results
A total of 420 lesions were analyzed from 35 MS (female (F):22 (62.9%); median age (range):38 years (y) (22–61), median disease duration:7.38y (0.38–20.99)) and 12 SVD patients (F:11 (100%); 54y (40–66)). MS T2-weighted lesions that increased in volume between MRI time points demonstrated movement toward the cortex (
p
= 0.01), whereas those that decreased in volume moved toward the center (
p
< 0.0001). Lesion volume changes related to SVD demonstrated no effect on movement direction over time. Both expanding (
p
= 0.03) and contracting (
p
= 0.01) MS lesions demonstrated greater distances between centroids when compared to SVD.
Conclusion
Lesion dynamics may reveal distinct characteristics associated with the biology of disease while providing further insights into the behavior of inflammatory CNS disorders.</description><subject>Bayesian analysis</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Mathematical models</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Regression analysis</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kctu1TAQhi1ERQ-FF2CBLLFhEzq-5bJE5SpVYtOuI8eZHLly7OBJKH0THhefnkIlFmxsjef7_xnrZ-yVgHcCoDknAC1MBVJWQkDbVd0TthNalVKb7inbgdJQGWX0KXtOdAMAbWk8Y6fKqBak0Tv264PP6FafIrdx5LPdR79uI_I08dHTEqzDGeNaimnCzAdcbxEjp5Buwx3Hn0uR-bi_V8cUq8eXeQurXwJycgFzIk88IJVJxC1xl-bFZhz5mjjNNgT-A4kwHKaiJXzBTiYbCF8-3Gfs-tPHq4sv1eW3z18v3l9WTjVmrWqYOhylUKZuJ9PUrhkcDq2qrVFuFBKbZqgBhlo3YJwz2jnhRudalMMA0Kkz9vbou-T0fUNa-9mTwxBsxLRRL4tSCqGauqBv_kFv0pZj2a5QnZBal6NQ8ki58mfKOPVL9rPNd72A_pBbf8ytL7n197n1hy1eP1hvw4zjX8mfoAqgjgCVVtxjfpz9H9vfV1ambQ</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Moog, Tatum M.</creator><creator>McCreary, Morgan</creator><creator>Wilson, Andrew</creator><creator>Stanley, Thomas</creator><creator>Yu, Fang F.</creator><creator>Pinho, Marco</creator><creator>Guo, Xiaohu</creator><creator>Okuda, Darin T.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6499-1523</orcidid></search><sort><creationdate>20220801</creationdate><title>Direction and magnitude of displacement differ between slowly expanding and non-expanding multiple sclerosis lesions as compared to small vessel disease</title><author>Moog, Tatum M. ; McCreary, Morgan ; Wilson, Andrew ; Stanley, Thomas ; Yu, Fang F. ; Pinho, Marco ; Guo, Xiaohu ; Okuda, Darin T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-60f9ed213568f576c7bceb836a53cd12e77b600b64705cc54cc1cdcc8e2bb0093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bayesian analysis</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>Mathematical models</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Regression analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moog, Tatum M.</creatorcontrib><creatorcontrib>McCreary, Morgan</creatorcontrib><creatorcontrib>Wilson, Andrew</creatorcontrib><creatorcontrib>Stanley, Thomas</creatorcontrib><creatorcontrib>Yu, Fang F.</creatorcontrib><creatorcontrib>Pinho, Marco</creatorcontrib><creatorcontrib>Guo, Xiaohu</creatorcontrib><creatorcontrib>Okuda, Darin T.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moog, Tatum M.</au><au>McCreary, Morgan</au><au>Wilson, Andrew</au><au>Stanley, Thomas</au><au>Yu, Fang F.</au><au>Pinho, Marco</au><au>Guo, Xiaohu</au><au>Okuda, Darin T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direction and magnitude of displacement differ between slowly expanding and non-expanding multiple sclerosis lesions as compared to small vessel disease</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>269</volume><issue>8</issue><spage>4459</spage><epage>4468</epage><pages>4459-4468</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Background and purpose
Differentiating between multiple sclerosis (MS) and small vessel disease (SVD) lesions represents a key challenge in the day-to-day management of patients. We aimed to distinguish between MS and SVD by identifying the dynamics of lesion movement patterns between enlarging and contracting foci from two MRI time points.
Methods
Standardized 3-Tesla 3-dimensional brain magnetic resonance imaging (MRI) studies were performed at two time points on enrolled MS and SVD patients. Selected supratentorial lesions were segmented and longitudinal changes in the direction of lesion displacement and magnitude along with the evolution of contracting and expanding T1-weighted and T2-weighted MS lesions were quantified based on lesion centroid positioning. Bayesian linear mixed effects regression models were constructed to evaluate associations between changes in lesion transitions and disease state.
Results
A total of 420 lesions were analyzed from 35 MS (female (F):22 (62.9%); median age (range):38 years (y) (22–61), median disease duration:7.38y (0.38–20.99)) and 12 SVD patients (F:11 (100%); 54y (40–66)). MS T2-weighted lesions that increased in volume between MRI time points demonstrated movement toward the cortex (
p
= 0.01), whereas those that decreased in volume moved toward the center (
p
< 0.0001). Lesion volume changes related to SVD demonstrated no effect on movement direction over time. Both expanding (
p
= 0.03) and contracting (
p
= 0.01) MS lesions demonstrated greater distances between centroids when compared to SVD.
Conclusion
Lesion dynamics may reveal distinct characteristics associated with the biology of disease while providing further insights into the behavior of inflammatory CNS disorders.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35380254</pmid><doi>10.1007/s00415-022-11089-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6499-1523</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Bayesian analysis Lesions Magnetic resonance imaging Mathematical models Medicine Medicine & Public Health Multiple sclerosis Neuroimaging Neurology Neuroradiology Neurosciences Original Communication Regression analysis |
| title | Direction and magnitude of displacement differ between slowly expanding and non-expanding multiple sclerosis lesions as compared to small vessel disease |
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