Effect of Itraconazole and Its Metabolite Hydroxyitraconazole on the Blood Concentrations of Cyclosporine and Tacrolimus in Lung Transplant Recipients

Invasive Aspergillus infection is a major factor for poor prognosis in patients receiving lung transplantation (LT). An antifungal agent, itraconazole (ITCZ), that has antimicrobial activity against Aspergillus species, is used as a prophylactic agent against Aspergillus infection after LT. ITCZ and...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/04/01, Vol.45(4), pp.397-402
Hauptverfasser:	Matsuda, Yuya, Nakagawa, Shunsaku, Yano, Ikuko, Masuda, Satohiro, Imai, Satoshi, Yonezawa, Atsushi, Yamamoto, Takashi, Sugimoto, Mitsuhiro, Tsuda, Masahiro, Tsuzuki, Tetsunori, Omura, Tomohiro, Nakagawa, Takayuki, Chen-Yoshikawa, Toyofumi Fengshi, Nagao, Miki, Date, Hiroshi, Matsubara, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal agents Antimicrobial activity Aspergillus Blood levels Calcineurin calcineurin inhibitor Calcineurin inhibitors Cyclosporine - pharmacology Cyclosporine - therapeutic use Cyclosporins drug–drug interaction Humans hydroxyitraconazole Immunosuppressive agents Itraconazole Itraconazole - analogs & derivatives Itraconazole - pharmacology Lung Lung transplantation P-Glycoprotein Plasma Plasma levels Retrospective Studies Tacrolimus Tacrolimus - therapeutic use therapeutic drug monitoring Transplant Recipients Transplants & implants
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