Clinical Aspects of Drug–Drug Interaction and Drug Nephrotoxicity at Renal Organic Cation Transporters 2 (OCT2) and Multidrug and Toxin Exclusion 1, and 2-K (MATE1/MATE2-K)

The organic cation transporter 2 (OCT2) belongs to the SLC22 family, while the multidrug and toxin extrusion 1 and 2-K (MATE1/MATE2-K) belong to the SLC47 family, are localized to the basolateral and apical membrane of human renal proximal tubular epithelial cells, respectively. They are polyspecifi...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/04/01, Vol.45(4), pp.382-393
Hauptverfasser:	Saad, Abdulaziz Ahmed A., Zhang, Fan, Mohammed, Eyad Abdulwhab H., Wu, Xin’an
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Cisplatin Clinical aspects Drug interaction Drug Interactions Drug-Related Side Effects and Adverse Reactions - metabolism Drugs drug–drug interaction Epithelial cells Humans Kidney - metabolism Kidneys multidrug and toxin extrusion 1 and 2-K nephrotoxicity Oct-2 protein Organic Cation Transport Proteins - metabolism Organic cation transporter organic cation transporter 2 Organic Cation Transporter 2 - metabolism Pharmacokinetics Plasma membranes Toxicity
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