Methylselenocysteine Potentiates Etoposide-Induced Cytotoxicity by Enhancing Gap Junction Activity

Homomeric or heteromeric connexin (Cx) hemichannels-composed gap junction (GJ) intercellular channel can mediate direct cell-to-cell communication. Accumulating studies indicate that GJs potentiate the cytotoxicity of antitumor drugs in malignant cells. Methylselenocysteine (MSC), a selenium compoun...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/04/01, Vol.45(4), pp.467-476
Hauptverfasser:	Zhou, Xueli, Li, Man, Cheng, Qianqian, Shao, Yu, Wang, Wei, Du, Qianyu, Liu, Jing, Yang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Antineoplastic drugs Cell density Cell interactions chemomodulatory effect Chemotherapy Cisplatin Connexin 32 Connexins - metabolism Cytotoxicity Doxycycline Etoposide Etoposide - pharmacology gap junction Gap Junctions Gene expression Glutathione HeLa Cells Humans methylselenocysteine Post-transcription posttranscriptional modification Selenium compounds Selenocysteine - analogs & derivatives Tumor cell lines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!