Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis
To identify metabolites in presurgical blood associated with risk of persistent postsurgical pelvic pain 1 year after endometriosis surgery in adolescent and young adult patients. Prospective observational study within the Women’s Health Study: From Adolescence to Adulthood, a US-based longitudinal...
Gespeichert in:
| Veröffentlicht in: | Fertility and sterility 2022-06, Vol.117 (6), p.1235-1245 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1245 |
|---|---|
| container_issue | 6 |
| container_start_page | 1235 |
| container_title | Fertility and sterility |
| container_volume | 117 |
| creator | Sasamoto, Naoko Zeleznik, Oana A. Vitonis, Allison F. Missmer, Stacey A. Laufer, Marc R. Avila-Pacheco, Julian Clish, Clary B. Terry, Kathryn L. |
| description | To identify metabolites in presurgical blood associated with risk of persistent postsurgical pelvic pain 1 year after endometriosis surgery in adolescent and young adult patients.
Prospective observational study within the Women’s Health Study: From Adolescence to Adulthood, a US-based longitudinal cohort of adolescents and women enrolled from 2012–2018.
Two tertiary care hospitals.
Laparoscopically confirmed endometriosis patients (n = 180) with blood collected before their endometriosis surgery. Of these, 77 patients additionally provided blood samples 5 weeks to 6 months after their surgery. We measured plasma metabolites using liquid chromatography tandem mass spectrometry, and a total of 390 known metabolites were included in our analysis.
None.
Persistent postsurgical pelvic pain, defined as severe, life-impacting pelvic pain 1 year after endometriosis surgery.
Most patients (>95%) were at stage I/II of the revised American Society for Reproductive Medicine classification. Their average age at diagnosis was 18.7 years, with 36% reporting persistent postsurgical pelvic pain. Of the 21 metabolites in presurgical blood that were associated with risk of persistent postsurgical pelvic pain, 19 metabolites, which were mainly lipid metabolites, were associated with increased risk. Only 2 metabolites—pregnenolone sulfate (odds ratio = 0.64, 95% confidence interval = 0.44–0.92) and fucose (odds ratio = 0.69, 95% confidence interval = 0.47–0.97)—were associated with decreased risk. Metabolite set enrichment analysis revealed that higher levels of lysophosphatidylethanolamines (false discovery rate = 0.01) and lysophosphatidylcholines (false discovery rate = 0.01) in presurgical blood were associated with increased risk of persistent postsurgical pelvic pain.
Our results suggest that dysregulation of multiple groups of lipid metabolites may play a role in the persistence of pelvic pain postsurgery among young endometriosis patients.
Metabolitos sanguíneos prequirúrgicos y riesgo de dolor pélvico posquirúrgico en pacientes jóvenes con endometriosis.
Identificar metabolitos en sangre prequirúrgica asociados con el riesgo de dolor pélvico posquirúrgico persistente 1 año después de la cirugía de endometriosis en pacientes adolescentes y adultas jóvenes.
estudio observacional prospectivo dentro del Estudio de salud de la mujer: de la adolescencia a la edad adulta, un estudio longitudinal basado en cohorte de adolescentes y mujeres reclutadas en EE. UU, entre 2012 y |
| doi_str_mv | 10.1016/j.fertnstert.2022.02.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2646940718</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028222001273</els_id><sourcerecordid>2646940718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-f1b39efb94a3c4450495044d2279b02c5c552f5d3b36ba0561b36f8c1dc053593</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EokvhLyAfuWQZf-7mCBUFpEpwgLPl2JPFSzYOHqeo_x5XW8oR6bVHlp6ZkR_GuICtAGHfHrcjljpTbfdWgpRbaBHyCdsIY2xnrFFP2QZAmA7kXl6wF0RHALBiJ5-zC2WU3YHVG3b4WpDWckjBT3yYco78hNUPeUoVifs58pLoJ88jXzLVR3TB6TYFvvg085a7vM6H9qoJ50r8d6o_OM4xt1klZUr0kj0b_UT46qFesu_XH75dfepuvnz8fPXupgta6tqNYlA9jkOvvQpaG9B9OzpKuesHkMEEY-RoohqUHTwY23g77oOIAYwyvbpkb85zl5J_rUjVnRIFnCY_Y17JSattr2En9g3dn9FQMlHB0S0lnXy5cwLcvWZ3dP80u3vNDlqEbK2vH7aswwnjY-Nfrw14fwaw_fU2YXEUmpqAMRUM1cWc_r_lD-VHlZg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2646940718</pqid></control><display><type>article</type><title>Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><source>Alma/SFX Local Collection</source><creator>Sasamoto, Naoko ; Zeleznik, Oana A. ; Vitonis, Allison F. ; Missmer, Stacey A. ; Laufer, Marc R. ; Avila-Pacheco, Julian ; Clish, Clary B. ; Terry, Kathryn L.</creator><creatorcontrib>Sasamoto, Naoko ; Zeleznik, Oana A. ; Vitonis, Allison F. ; Missmer, Stacey A. ; Laufer, Marc R. ; Avila-Pacheco, Julian ; Clish, Clary B. ; Terry, Kathryn L.</creatorcontrib><description>To identify metabolites in presurgical blood associated with risk of persistent postsurgical pelvic pain 1 year after endometriosis surgery in adolescent and young adult patients.
Prospective observational study within the Women’s Health Study: From Adolescence to Adulthood, a US-based longitudinal cohort of adolescents and women enrolled from 2012–2018.
Two tertiary care hospitals.
Laparoscopically confirmed endometriosis patients (n = 180) with blood collected before their endometriosis surgery. Of these, 77 patients additionally provided blood samples 5 weeks to 6 months after their surgery. We measured plasma metabolites using liquid chromatography tandem mass spectrometry, and a total of 390 known metabolites were included in our analysis.
None.
Persistent postsurgical pelvic pain, defined as severe, life-impacting pelvic pain 1 year after endometriosis surgery.
Most patients (>95%) were at stage I/II of the revised American Society for Reproductive Medicine classification. Their average age at diagnosis was 18.7 years, with 36% reporting persistent postsurgical pelvic pain. Of the 21 metabolites in presurgical blood that were associated with risk of persistent postsurgical pelvic pain, 19 metabolites, which were mainly lipid metabolites, were associated with increased risk. Only 2 metabolites—pregnenolone sulfate (odds ratio = 0.64, 95% confidence interval = 0.44–0.92) and fucose (odds ratio = 0.69, 95% confidence interval = 0.47–0.97)—were associated with decreased risk. Metabolite set enrichment analysis revealed that higher levels of lysophosphatidylethanolamines (false discovery rate = 0.01) and lysophosphatidylcholines (false discovery rate = 0.01) in presurgical blood were associated with increased risk of persistent postsurgical pelvic pain.
Our results suggest that dysregulation of multiple groups of lipid metabolites may play a role in the persistence of pelvic pain postsurgery among young endometriosis patients.
Metabolitos sanguíneos prequirúrgicos y riesgo de dolor pélvico posquirúrgico en pacientes jóvenes con endometriosis.
Identificar metabolitos en sangre prequirúrgica asociados con el riesgo de dolor pélvico posquirúrgico persistente 1 año después de la cirugía de endometriosis en pacientes adolescentes y adultas jóvenes.
estudio observacional prospectivo dentro del Estudio de salud de la mujer: de la adolescencia a la edad adulta, un estudio longitudinal basado en cohorte de adolescentes y mujeres reclutadas en EE. UU, entre 2012 y 2018.
dos hospitales de atención terciaria.
Pacientes con endometriosis confirmada por laparoscopia (n = 180) con sangre extraída antes de la cirugía de endometriosis. De estas, 77 pacientes adicionalmente proporcionaron muestras de sangre a las 5 semanas hasta los 6 meses después de su cirugía. Se han medido los metabolitos plasmáticos utilizando espectrometría de masas en tándem de cromatografía líquida, y un total de 390 metabolitos conocidos se incluyeron en nuestro análisis.
Ninguna.
dolor pélvico posquirúrgico persistente, definido como dolor pélvico intenso que afecta la vida 1 año después de la endometriosis cirugía.
La mayoría de los pacientes (>95 %) se encontraban en el estadio I/II de la clasificación revisada de la Sociedad Estadounidense de Medicina Reproductiva. La edad media en el momento del diagnóstico fue de 18,7 años, y el 36 % informó dolor pélvico posquirúrgico persistente. De los 21 metabolitos en sangre prequirúrgica que se asociaron con el riesgo de dolor pélvico posquirúrgico persistente, 19 metabolitos, que eran principalmente metabolitos lipídicos, se asociaron con un mayor riesgo. Solo 2 metabolitos: sulfato de pregnenolona (odds ratio = 0,64, intervalo de confianza del 95 % = 0,44–0,92) y fucosa (odds ratio= 0,69, intervalo de confianza del 95 % = 0,47–0,97) se asociaron con una disminución del riesgo. El análisis de enriquecimiento del conjunto de metabolitos reveló que los niveles más altos de lisofosfatidiletanolaminas (tasa de descubrimiento falso =0.01) y lisofosfatidilcolinas (tasa de descubrimiento falso= 0,01) en la sangre prequirúrgica se asociaron con un mayor riesgo de dolor pélvico posquirúrgico persistente.
Nuestros resultados sugieren que la desregulación de múltiples grupos de metabolitos de lípidos puede jugar un papel en la persistencia del dolor postoperatorio pélvico entre pacientes jóvenes con endometriosis.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2022.02.012</identifier><identifier>PMID: 35367064</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; biomarkers ; endometriosis ; Endometriosis - complications ; Endometriosis - diagnosis ; Endometriosis - surgery ; Female ; Humans ; Laparoscopy - adverse effects ; Lipids ; metabolomics ; Pain, Postoperative - diagnosis ; Pain, Postoperative - etiology ; Pelvic Pain - diagnosis ; Pelvic Pain - etiology ; Pelvic Pain - surgery ; Pelvis ; postsurgical pelvic pain ; Young Adult</subject><ispartof>Fertility and sterility, 2022-06, Vol.117 (6), p.1235-1245</ispartof><rights>2022 American Society for Reproductive Medicine</rights><rights>Copyright © 2022 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-f1b39efb94a3c4450495044d2279b02c5c552f5d3b36ba0561b36f8c1dc053593</citedby><cites>FETCH-LOGICAL-c424t-f1b39efb94a3c4450495044d2279b02c5c552f5d3b36ba0561b36f8c1dc053593</cites><orcidid>0000-0002-4526-2181</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2022.02.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35367064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasamoto, Naoko</creatorcontrib><creatorcontrib>Zeleznik, Oana A.</creatorcontrib><creatorcontrib>Vitonis, Allison F.</creatorcontrib><creatorcontrib>Missmer, Stacey A.</creatorcontrib><creatorcontrib>Laufer, Marc R.</creatorcontrib><creatorcontrib>Avila-Pacheco, Julian</creatorcontrib><creatorcontrib>Clish, Clary B.</creatorcontrib><creatorcontrib>Terry, Kathryn L.</creatorcontrib><title>Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To identify metabolites in presurgical blood associated with risk of persistent postsurgical pelvic pain 1 year after endometriosis surgery in adolescent and young adult patients.
Prospective observational study within the Women’s Health Study: From Adolescence to Adulthood, a US-based longitudinal cohort of adolescents and women enrolled from 2012–2018.
Two tertiary care hospitals.
Laparoscopically confirmed endometriosis patients (n = 180) with blood collected before their endometriosis surgery. Of these, 77 patients additionally provided blood samples 5 weeks to 6 months after their surgery. We measured plasma metabolites using liquid chromatography tandem mass spectrometry, and a total of 390 known metabolites were included in our analysis.
None.
Persistent postsurgical pelvic pain, defined as severe, life-impacting pelvic pain 1 year after endometriosis surgery.
Most patients (>95%) were at stage I/II of the revised American Society for Reproductive Medicine classification. Their average age at diagnosis was 18.7 years, with 36% reporting persistent postsurgical pelvic pain. Of the 21 metabolites in presurgical blood that were associated with risk of persistent postsurgical pelvic pain, 19 metabolites, which were mainly lipid metabolites, were associated with increased risk. Only 2 metabolites—pregnenolone sulfate (odds ratio = 0.64, 95% confidence interval = 0.44–0.92) and fucose (odds ratio = 0.69, 95% confidence interval = 0.47–0.97)—were associated with decreased risk. Metabolite set enrichment analysis revealed that higher levels of lysophosphatidylethanolamines (false discovery rate = 0.01) and lysophosphatidylcholines (false discovery rate = 0.01) in presurgical blood were associated with increased risk of persistent postsurgical pelvic pain.
Our results suggest that dysregulation of multiple groups of lipid metabolites may play a role in the persistence of pelvic pain postsurgery among young endometriosis patients.
Metabolitos sanguíneos prequirúrgicos y riesgo de dolor pélvico posquirúrgico en pacientes jóvenes con endometriosis.
Identificar metabolitos en sangre prequirúrgica asociados con el riesgo de dolor pélvico posquirúrgico persistente 1 año después de la cirugía de endometriosis en pacientes adolescentes y adultas jóvenes.
estudio observacional prospectivo dentro del Estudio de salud de la mujer: de la adolescencia a la edad adulta, un estudio longitudinal basado en cohorte de adolescentes y mujeres reclutadas en EE. UU, entre 2012 y 2018.
dos hospitales de atención terciaria.
Pacientes con endometriosis confirmada por laparoscopia (n = 180) con sangre extraída antes de la cirugía de endometriosis. De estas, 77 pacientes adicionalmente proporcionaron muestras de sangre a las 5 semanas hasta los 6 meses después de su cirugía. Se han medido los metabolitos plasmáticos utilizando espectrometría de masas en tándem de cromatografía líquida, y un total de 390 metabolitos conocidos se incluyeron en nuestro análisis.
Ninguna.
dolor pélvico posquirúrgico persistente, definido como dolor pélvico intenso que afecta la vida 1 año después de la endometriosis cirugía.
La mayoría de los pacientes (>95 %) se encontraban en el estadio I/II de la clasificación revisada de la Sociedad Estadounidense de Medicina Reproductiva. La edad media en el momento del diagnóstico fue de 18,7 años, y el 36 % informó dolor pélvico posquirúrgico persistente. De los 21 metabolitos en sangre prequirúrgica que se asociaron con el riesgo de dolor pélvico posquirúrgico persistente, 19 metabolitos, que eran principalmente metabolitos lipídicos, se asociaron con un mayor riesgo. Solo 2 metabolitos: sulfato de pregnenolona (odds ratio = 0,64, intervalo de confianza del 95 % = 0,44–0,92) y fucosa (odds ratio= 0,69, intervalo de confianza del 95 % = 0,47–0,97) se asociaron con una disminución del riesgo. El análisis de enriquecimiento del conjunto de metabolitos reveló que los niveles más altos de lisofosfatidiletanolaminas (tasa de descubrimiento falso =0.01) y lisofosfatidilcolinas (tasa de descubrimiento falso= 0,01) en la sangre prequirúrgica se asociaron con un mayor riesgo de dolor pélvico posquirúrgico persistente.
Nuestros resultados sugieren que la desregulación de múltiples grupos de metabolitos de lípidos puede jugar un papel en la persistencia del dolor postoperatorio pélvico entre pacientes jóvenes con endometriosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>biomarkers</subject><subject>endometriosis</subject><subject>Endometriosis - complications</subject><subject>Endometriosis - diagnosis</subject><subject>Endometriosis - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Laparoscopy - adverse effects</subject><subject>Lipids</subject><subject>metabolomics</subject><subject>Pain, Postoperative - diagnosis</subject><subject>Pain, Postoperative - etiology</subject><subject>Pelvic Pain - diagnosis</subject><subject>Pelvic Pain - etiology</subject><subject>Pelvic Pain - surgery</subject><subject>Pelvis</subject><subject>postsurgical pelvic pain</subject><subject>Young Adult</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhLyAfuWQZf-7mCBUFpEpwgLPl2JPFSzYOHqeo_x5XW8oR6bVHlp6ZkR_GuICtAGHfHrcjljpTbfdWgpRbaBHyCdsIY2xnrFFP2QZAmA7kXl6wF0RHALBiJ5-zC2WU3YHVG3b4WpDWckjBT3yYco78hNUPeUoVifs58pLoJ88jXzLVR3TB6TYFvvg085a7vM6H9qoJ50r8d6o_OM4xt1klZUr0kj0b_UT46qFesu_XH75dfepuvnz8fPXupgta6tqNYlA9jkOvvQpaG9B9OzpKuesHkMEEY-RoohqUHTwY23g77oOIAYwyvbpkb85zl5J_rUjVnRIFnCY_Y17JSattr2En9g3dn9FQMlHB0S0lnXy5cwLcvWZ3dP80u3vNDlqEbK2vH7aswwnjY-Nfrw14fwaw_fU2YXEUmpqAMRUM1cWc_r_lD-VHlZg</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Sasamoto, Naoko</creator><creator>Zeleznik, Oana A.</creator><creator>Vitonis, Allison F.</creator><creator>Missmer, Stacey A.</creator><creator>Laufer, Marc R.</creator><creator>Avila-Pacheco, Julian</creator><creator>Clish, Clary B.</creator><creator>Terry, Kathryn L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4526-2181</orcidid></search><sort><creationdate>202206</creationdate><title>Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis</title><author>Sasamoto, Naoko ; Zeleznik, Oana A. ; Vitonis, Allison F. ; Missmer, Stacey A. ; Laufer, Marc R. ; Avila-Pacheco, Julian ; Clish, Clary B. ; Terry, Kathryn L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-f1b39efb94a3c4450495044d2279b02c5c552f5d3b36ba0561b36f8c1dc053593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>biomarkers</topic><topic>endometriosis</topic><topic>Endometriosis - complications</topic><topic>Endometriosis - diagnosis</topic><topic>Endometriosis - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Laparoscopy - adverse effects</topic><topic>Lipids</topic><topic>metabolomics</topic><topic>Pain, Postoperative - diagnosis</topic><topic>Pain, Postoperative - etiology</topic><topic>Pelvic Pain - diagnosis</topic><topic>Pelvic Pain - etiology</topic><topic>Pelvic Pain - surgery</topic><topic>Pelvis</topic><topic>postsurgical pelvic pain</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasamoto, Naoko</creatorcontrib><creatorcontrib>Zeleznik, Oana A.</creatorcontrib><creatorcontrib>Vitonis, Allison F.</creatorcontrib><creatorcontrib>Missmer, Stacey A.</creatorcontrib><creatorcontrib>Laufer, Marc R.</creatorcontrib><creatorcontrib>Avila-Pacheco, Julian</creatorcontrib><creatorcontrib>Clish, Clary B.</creatorcontrib><creatorcontrib>Terry, Kathryn L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasamoto, Naoko</au><au>Zeleznik, Oana A.</au><au>Vitonis, Allison F.</au><au>Missmer, Stacey A.</au><au>Laufer, Marc R.</au><au>Avila-Pacheco, Julian</au><au>Clish, Clary B.</au><au>Terry, Kathryn L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2022-06</date><risdate>2022</risdate><volume>117</volume><issue>6</issue><spage>1235</spage><epage>1245</epage><pages>1235-1245</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>To identify metabolites in presurgical blood associated with risk of persistent postsurgical pelvic pain 1 year after endometriosis surgery in adolescent and young adult patients.
Prospective observational study within the Women’s Health Study: From Adolescence to Adulthood, a US-based longitudinal cohort of adolescents and women enrolled from 2012–2018.
Two tertiary care hospitals.
Laparoscopically confirmed endometriosis patients (n = 180) with blood collected before their endometriosis surgery. Of these, 77 patients additionally provided blood samples 5 weeks to 6 months after their surgery. We measured plasma metabolites using liquid chromatography tandem mass spectrometry, and a total of 390 known metabolites were included in our analysis.
None.
Persistent postsurgical pelvic pain, defined as severe, life-impacting pelvic pain 1 year after endometriosis surgery.
Most patients (>95%) were at stage I/II of the revised American Society for Reproductive Medicine classification. Their average age at diagnosis was 18.7 years, with 36% reporting persistent postsurgical pelvic pain. Of the 21 metabolites in presurgical blood that were associated with risk of persistent postsurgical pelvic pain, 19 metabolites, which were mainly lipid metabolites, were associated with increased risk. Only 2 metabolites—pregnenolone sulfate (odds ratio = 0.64, 95% confidence interval = 0.44–0.92) and fucose (odds ratio = 0.69, 95% confidence interval = 0.47–0.97)—were associated with decreased risk. Metabolite set enrichment analysis revealed that higher levels of lysophosphatidylethanolamines (false discovery rate = 0.01) and lysophosphatidylcholines (false discovery rate = 0.01) in presurgical blood were associated with increased risk of persistent postsurgical pelvic pain.
Our results suggest that dysregulation of multiple groups of lipid metabolites may play a role in the persistence of pelvic pain postsurgery among young endometriosis patients.
Metabolitos sanguíneos prequirúrgicos y riesgo de dolor pélvico posquirúrgico en pacientes jóvenes con endometriosis.
Identificar metabolitos en sangre prequirúrgica asociados con el riesgo de dolor pélvico posquirúrgico persistente 1 año después de la cirugía de endometriosis en pacientes adolescentes y adultas jóvenes.
estudio observacional prospectivo dentro del Estudio de salud de la mujer: de la adolescencia a la edad adulta, un estudio longitudinal basado en cohorte de adolescentes y mujeres reclutadas en EE. UU, entre 2012 y 2018.
dos hospitales de atención terciaria.
Pacientes con endometriosis confirmada por laparoscopia (n = 180) con sangre extraída antes de la cirugía de endometriosis. De estas, 77 pacientes adicionalmente proporcionaron muestras de sangre a las 5 semanas hasta los 6 meses después de su cirugía. Se han medido los metabolitos plasmáticos utilizando espectrometría de masas en tándem de cromatografía líquida, y un total de 390 metabolitos conocidos se incluyeron en nuestro análisis.
Ninguna.
dolor pélvico posquirúrgico persistente, definido como dolor pélvico intenso que afecta la vida 1 año después de la endometriosis cirugía.
La mayoría de los pacientes (>95 %) se encontraban en el estadio I/II de la clasificación revisada de la Sociedad Estadounidense de Medicina Reproductiva. La edad media en el momento del diagnóstico fue de 18,7 años, y el 36 % informó dolor pélvico posquirúrgico persistente. De los 21 metabolitos en sangre prequirúrgica que se asociaron con el riesgo de dolor pélvico posquirúrgico persistente, 19 metabolitos, que eran principalmente metabolitos lipídicos, se asociaron con un mayor riesgo. Solo 2 metabolitos: sulfato de pregnenolona (odds ratio = 0,64, intervalo de confianza del 95 % = 0,44–0,92) y fucosa (odds ratio= 0,69, intervalo de confianza del 95 % = 0,47–0,97) se asociaron con una disminución del riesgo. El análisis de enriquecimiento del conjunto de metabolitos reveló que los niveles más altos de lisofosfatidiletanolaminas (tasa de descubrimiento falso =0.01) y lisofosfatidilcolinas (tasa de descubrimiento falso= 0,01) en la sangre prequirúrgica se asociaron con un mayor riesgo de dolor pélvico posquirúrgico persistente.
Nuestros resultados sugieren que la desregulación de múltiples grupos de metabolitos de lípidos puede jugar un papel en la persistencia del dolor postoperatorio pélvico entre pacientes jóvenes con endometriosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35367064</pmid><doi>10.1016/j.fertnstert.2022.02.012</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4526-2181</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 2022-06, Vol.117 (6), p.1235-1245 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2646940718 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Adolescent Adult biomarkers endometriosis Endometriosis - complications Endometriosis - diagnosis Endometriosis - surgery Female Humans Laparoscopy - adverse effects Lipids metabolomics Pain, Postoperative - diagnosis Pain, Postoperative - etiology Pelvic Pain - diagnosis Pelvic Pain - etiology Pelvic Pain - surgery Pelvis postsurgical pelvic pain Young Adult |
| title | Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T16%3A18%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Presurgical%20blood%20metabolites%20and%20risk%20of%20postsurgical%20pelvic%20pain%20in%20young%20patients%20with%20endometriosis&rft.jtitle=Fertility%20and%20sterility&rft.au=Sasamoto,%20Naoko&rft.date=2022-06&rft.volume=117&rft.issue=6&rft.spage=1235&rft.epage=1245&rft.pages=1235-1245&rft.issn=0015-0282&rft.eissn=1556-5653&rft_id=info:doi/10.1016/j.fertnstert.2022.02.012&rft_dat=%3Cproquest_cross%3E2646940718%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2646940718&rft_id=info:pmid/35367064&rft_els_id=S0015028222001273&rfr_iscdi=true |