Prevalence, Pathogenesis and Management of Anemia in Inflammatory Bowel Disease: An IG-IBD Multicenter, Prospective, and Observational Study
Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), with a 6% to 74% prevalence and a negative impact on patient survival and quality of life, although the prevalence is apparently declining due to improved disease treatment. We aimed to investigate the prevalence,...
Gespeichert in:
| Veröffentlicht in: | Inflammatory bowel diseases 2023-01, Vol.29 (1), p.76-84 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 84 |
|---|---|
| container_issue | 1 |
| container_start_page | 76 |
| container_title | Inflammatory bowel diseases |
| container_volume | 29 |
| creator | Bergamaschi, Gaetano Castiglione, Fabiana D'Incà, Renata Astegiano, Marco Fries, Walter Milla, Monica Ciacci, Carolina Rizzello, Fernando Saibeni, Simone Ciccocioppo, Rachele Orlando, Ambrogio Bossa, Fabrizio Principi, Mariabeatrice Vernia, Piero Ricci, Chiara Scribano, Maria L Bodini, Giorgia Mazzucco, Dario Bassotti, Gabrio Riegler, Gabriele Buda, Andrea Neri, Matteo Caprioli, Flavio Monica, Fabio Manca, Aldo Villa, Erica Fiorino, Gionata Comberlato, Michele Aronico, Nicola Della Corte, Cristina Caccaro, Roberta Gionchetti, Paolo Giuffrida, Paolo Iovino, Paola Lenti, Marco V Mengoli, Caterina Pellegrini, Lucienne Pieraccini, Alberto Ribaldone, Davide Testa, Anna Ubezio, Cristina Viola, Anna Vecchi, Maurizio Klersy, Catherine Di Sabatino, Antonio |
| description | Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), with a 6% to 74% prevalence and a negative impact on patient survival and quality of life, although the prevalence is apparently declining due to improved disease treatment. We aimed to investigate the prevalence, pathogenesis, and clinical correlates of anemia in Italian patients with IBD.
A multicenter, prospective, observational study, involving 28 Italian gastroenterology centers, was conducted to investigate the epidemiology and consequences of IBD-associated anemia. Clinical and laboratory data of anemic patients were obtained at study enrolment.
Anemia was diagnosed in 737 of 5416 adult IBD outpatients (prevalence 13.6%); females were more commonly affected than males (odds ratio, 1.5; 95% confidence interval [CI], 1.2-1.7) and had more severe anemia. In the majority of cases, anemia was due to iron deficiency (62.5% of cases; 95% CI, 58.3%-66.6%), either isolated or in association with inflammation and/or vitamin deficiencies; anemia of inflammation accounted for only 8.3% of cases. More severe anemia was associated with increasing fatigue and worse quality of life. Only 68.9% of anemic patients with iron deficiency (95% CI, 63.4%-73.8%) and 34.6% of those with vitamin deficiencies (95% CI, 26.2%-44.2%) were properly treated with supplementation therapy.
In Italy, the prevalence of IBD-associated anemia is lower than previously reported. Anemia of IBD is most commonly due to iron deficiency and contributes to fatigue and poor quality of life, but remains untreated in a large proportion of patients with iron and/or vitamin deficiencies. This study is registered at clinicaltrials.gov as NCT02872376. |
| doi_str_mv | 10.1093/ibd/izac054 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2646725706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2646725706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c289t-f5e04cbe1495c48dfcc55eb9e46abf9ad59beef67df8fd8fb1353e0b669e441d3</originalsourceid><addsrcrecordid>eNo9kE1P3DAQhq2KCijl1DvyEalN10kcb8xt-exKi0Bqe47G9hiMEmexna22v6E_GiOWyofx4ZlnZl5CvpTse8lkPXPKzNxf0KzhH8hh2dSi4C3ne_nP5m3BpGwPyKcYnxir8pP75KDOkKjL6pD8uw-4gR69xm_0HtLj-IAeo4sUvKG34OEBB_SJjpYuPA4OqPN06W0PwwBpDFt6Pv7Bnl66iBDxLFN0eVMszy_p7dQnp3MzhuwOY1yjTm6TB72671TEsIHkRg89_Zkms_1MPlroIx7v6hH5fX316-JHsbq7WV4sVoWuWpkK2yDjWmHJZaN5a6zWTYNKIhegrATTSIVoxdzY1prWqjLfi0wJkRFemvqInL5512F8njCmbnBRY9-Dx3GKXSW4mFfNnImMfn1Ddd4_BrTdOrgBwrYrWfcaf5fj73bxZ_pkJ57UgOY_-553_QKyFYRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2646725706</pqid></control><display><type>article</type><title>Prevalence, Pathogenesis and Management of Anemia in Inflammatory Bowel Disease: An IG-IBD Multicenter, Prospective, and Observational Study</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Bergamaschi, Gaetano ; Castiglione, Fabiana ; D'Incà, Renata ; Astegiano, Marco ; Fries, Walter ; Milla, Monica ; Ciacci, Carolina ; Rizzello, Fernando ; Saibeni, Simone ; Ciccocioppo, Rachele ; Orlando, Ambrogio ; Bossa, Fabrizio ; Principi, Mariabeatrice ; Vernia, Piero ; Ricci, Chiara ; Scribano, Maria L ; Bodini, Giorgia ; Mazzucco, Dario ; Bassotti, Gabrio ; Riegler, Gabriele ; Buda, Andrea ; Neri, Matteo ; Caprioli, Flavio ; Monica, Fabio ; Manca, Aldo ; Villa, Erica ; Fiorino, Gionata ; Comberlato, Michele ; Aronico, Nicola ; Della Corte, Cristina ; Caccaro, Roberta ; Gionchetti, Paolo ; Giuffrida, Paolo ; Iovino, Paola ; Lenti, Marco V ; Mengoli, Caterina ; Pellegrini, Lucienne ; Pieraccini, Alberto ; Ribaldone, Davide ; Testa, Anna ; Ubezio, Cristina ; Viola, Anna ; Vecchi, Maurizio ; Klersy, Catherine ; Di Sabatino, Antonio</creator><creatorcontrib>Bergamaschi, Gaetano ; Castiglione, Fabiana ; D'Incà, Renata ; Astegiano, Marco ; Fries, Walter ; Milla, Monica ; Ciacci, Carolina ; Rizzello, Fernando ; Saibeni, Simone ; Ciccocioppo, Rachele ; Orlando, Ambrogio ; Bossa, Fabrizio ; Principi, Mariabeatrice ; Vernia, Piero ; Ricci, Chiara ; Scribano, Maria L ; Bodini, Giorgia ; Mazzucco, Dario ; Bassotti, Gabrio ; Riegler, Gabriele ; Buda, Andrea ; Neri, Matteo ; Caprioli, Flavio ; Monica, Fabio ; Manca, Aldo ; Villa, Erica ; Fiorino, Gionata ; Comberlato, Michele ; Aronico, Nicola ; Della Corte, Cristina ; Caccaro, Roberta ; Gionchetti, Paolo ; Giuffrida, Paolo ; Iovino, Paola ; Lenti, Marco V ; Mengoli, Caterina ; Pellegrini, Lucienne ; Pieraccini, Alberto ; Ribaldone, Davide ; Testa, Anna ; Ubezio, Cristina ; Viola, Anna ; Vecchi, Maurizio ; Klersy, Catherine ; Di Sabatino, Antonio</creatorcontrib><description>Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), with a 6% to 74% prevalence and a negative impact on patient survival and quality of life, although the prevalence is apparently declining due to improved disease treatment. We aimed to investigate the prevalence, pathogenesis, and clinical correlates of anemia in Italian patients with IBD.
A multicenter, prospective, observational study, involving 28 Italian gastroenterology centers, was conducted to investigate the epidemiology and consequences of IBD-associated anemia. Clinical and laboratory data of anemic patients were obtained at study enrolment.
Anemia was diagnosed in 737 of 5416 adult IBD outpatients (prevalence 13.6%); females were more commonly affected than males (odds ratio, 1.5; 95% confidence interval [CI], 1.2-1.7) and had more severe anemia. In the majority of cases, anemia was due to iron deficiency (62.5% of cases; 95% CI, 58.3%-66.6%), either isolated or in association with inflammation and/or vitamin deficiencies; anemia of inflammation accounted for only 8.3% of cases. More severe anemia was associated with increasing fatigue and worse quality of life. Only 68.9% of anemic patients with iron deficiency (95% CI, 63.4%-73.8%) and 34.6% of those with vitamin deficiencies (95% CI, 26.2%-44.2%) were properly treated with supplementation therapy.
In Italy, the prevalence of IBD-associated anemia is lower than previously reported. Anemia of IBD is most commonly due to iron deficiency and contributes to fatigue and poor quality of life, but remains untreated in a large proportion of patients with iron and/or vitamin deficiencies. This study is registered at clinicaltrials.gov as NCT02872376.</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izac054</identifier><identifier>PMID: 35366312</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Anemia - epidemiology ; Anemia - etiology ; Anemia - therapy ; Anemia, Iron-Deficiency - epidemiology ; Anemia, Iron-Deficiency - etiology ; Anemia, Iron-Deficiency - therapy ; Avitaminosis - complications ; Fatigue - etiology ; Female ; Humans ; Inflammation - complications ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - epidemiology ; Iron Deficiencies ; Male ; Prevalence ; Prospective Studies ; Quality of Life</subject><ispartof>Inflammatory bowel diseases, 2023-01, Vol.29 (1), p.76-84</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved.
For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-f5e04cbe1495c48dfcc55eb9e46abf9ad59beef67df8fd8fb1353e0b669e441d3</citedby><cites>FETCH-LOGICAL-c289t-f5e04cbe1495c48dfcc55eb9e46abf9ad59beef67df8fd8fb1353e0b669e441d3</cites><orcidid>0000-0001-5677-2534 ; 0000-0001-5623-2968 ; 0000-0003-1558-8604 ; 0000-0002-0302-8645</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35366312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bergamaschi, Gaetano</creatorcontrib><creatorcontrib>Castiglione, Fabiana</creatorcontrib><creatorcontrib>D'Incà, Renata</creatorcontrib><creatorcontrib>Astegiano, Marco</creatorcontrib><creatorcontrib>Fries, Walter</creatorcontrib><creatorcontrib>Milla, Monica</creatorcontrib><creatorcontrib>Ciacci, Carolina</creatorcontrib><creatorcontrib>Rizzello, Fernando</creatorcontrib><creatorcontrib>Saibeni, Simone</creatorcontrib><creatorcontrib>Ciccocioppo, Rachele</creatorcontrib><creatorcontrib>Orlando, Ambrogio</creatorcontrib><creatorcontrib>Bossa, Fabrizio</creatorcontrib><creatorcontrib>Principi, Mariabeatrice</creatorcontrib><creatorcontrib>Vernia, Piero</creatorcontrib><creatorcontrib>Ricci, Chiara</creatorcontrib><creatorcontrib>Scribano, Maria L</creatorcontrib><creatorcontrib>Bodini, Giorgia</creatorcontrib><creatorcontrib>Mazzucco, Dario</creatorcontrib><creatorcontrib>Bassotti, Gabrio</creatorcontrib><creatorcontrib>Riegler, Gabriele</creatorcontrib><creatorcontrib>Buda, Andrea</creatorcontrib><creatorcontrib>Neri, Matteo</creatorcontrib><creatorcontrib>Caprioli, Flavio</creatorcontrib><creatorcontrib>Monica, Fabio</creatorcontrib><creatorcontrib>Manca, Aldo</creatorcontrib><creatorcontrib>Villa, Erica</creatorcontrib><creatorcontrib>Fiorino, Gionata</creatorcontrib><creatorcontrib>Comberlato, Michele</creatorcontrib><creatorcontrib>Aronico, Nicola</creatorcontrib><creatorcontrib>Della Corte, Cristina</creatorcontrib><creatorcontrib>Caccaro, Roberta</creatorcontrib><creatorcontrib>Gionchetti, Paolo</creatorcontrib><creatorcontrib>Giuffrida, Paolo</creatorcontrib><creatorcontrib>Iovino, Paola</creatorcontrib><creatorcontrib>Lenti, Marco V</creatorcontrib><creatorcontrib>Mengoli, Caterina</creatorcontrib><creatorcontrib>Pellegrini, Lucienne</creatorcontrib><creatorcontrib>Pieraccini, Alberto</creatorcontrib><creatorcontrib>Ribaldone, Davide</creatorcontrib><creatorcontrib>Testa, Anna</creatorcontrib><creatorcontrib>Ubezio, Cristina</creatorcontrib><creatorcontrib>Viola, Anna</creatorcontrib><creatorcontrib>Vecchi, Maurizio</creatorcontrib><creatorcontrib>Klersy, Catherine</creatorcontrib><creatorcontrib>Di Sabatino, Antonio</creatorcontrib><title>Prevalence, Pathogenesis and Management of Anemia in Inflammatory Bowel Disease: An IG-IBD Multicenter, Prospective, and Observational Study</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), with a 6% to 74% prevalence and a negative impact on patient survival and quality of life, although the prevalence is apparently declining due to improved disease treatment. We aimed to investigate the prevalence, pathogenesis, and clinical correlates of anemia in Italian patients with IBD.
A multicenter, prospective, observational study, involving 28 Italian gastroenterology centers, was conducted to investigate the epidemiology and consequences of IBD-associated anemia. Clinical and laboratory data of anemic patients were obtained at study enrolment.
Anemia was diagnosed in 737 of 5416 adult IBD outpatients (prevalence 13.6%); females were more commonly affected than males (odds ratio, 1.5; 95% confidence interval [CI], 1.2-1.7) and had more severe anemia. In the majority of cases, anemia was due to iron deficiency (62.5% of cases; 95% CI, 58.3%-66.6%), either isolated or in association with inflammation and/or vitamin deficiencies; anemia of inflammation accounted for only 8.3% of cases. More severe anemia was associated with increasing fatigue and worse quality of life. Only 68.9% of anemic patients with iron deficiency (95% CI, 63.4%-73.8%) and 34.6% of those with vitamin deficiencies (95% CI, 26.2%-44.2%) were properly treated with supplementation therapy.
In Italy, the prevalence of IBD-associated anemia is lower than previously reported. Anemia of IBD is most commonly due to iron deficiency and contributes to fatigue and poor quality of life, but remains untreated in a large proportion of patients with iron and/or vitamin deficiencies. This study is registered at clinicaltrials.gov as NCT02872376.</description><subject>Adult</subject><subject>Anemia - epidemiology</subject><subject>Anemia - etiology</subject><subject>Anemia - therapy</subject><subject>Anemia, Iron-Deficiency - epidemiology</subject><subject>Anemia, Iron-Deficiency - etiology</subject><subject>Anemia, Iron-Deficiency - therapy</subject><subject>Avitaminosis - complications</subject><subject>Fatigue - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Iron Deficiencies</subject><subject>Male</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1P3DAQhq2KCijl1DvyEalN10kcb8xt-exKi0Bqe47G9hiMEmexna22v6E_GiOWyofx4ZlnZl5CvpTse8lkPXPKzNxf0KzhH8hh2dSi4C3ne_nP5m3BpGwPyKcYnxir8pP75KDOkKjL6pD8uw-4gR69xm_0HtLj-IAeo4sUvKG34OEBB_SJjpYuPA4OqPN06W0PwwBpDFt6Pv7Bnl66iBDxLFN0eVMszy_p7dQnp3MzhuwOY1yjTm6TB72671TEsIHkRg89_Zkms_1MPlroIx7v6hH5fX316-JHsbq7WV4sVoWuWpkK2yDjWmHJZaN5a6zWTYNKIhegrATTSIVoxdzY1prWqjLfi0wJkRFemvqInL5512F8njCmbnBRY9-Dx3GKXSW4mFfNnImMfn1Ddd4_BrTdOrgBwrYrWfcaf5fj73bxZ_pkJ57UgOY_-553_QKyFYRA</recordid><startdate>20230105</startdate><enddate>20230105</enddate><creator>Bergamaschi, Gaetano</creator><creator>Castiglione, Fabiana</creator><creator>D'Incà, Renata</creator><creator>Astegiano, Marco</creator><creator>Fries, Walter</creator><creator>Milla, Monica</creator><creator>Ciacci, Carolina</creator><creator>Rizzello, Fernando</creator><creator>Saibeni, Simone</creator><creator>Ciccocioppo, Rachele</creator><creator>Orlando, Ambrogio</creator><creator>Bossa, Fabrizio</creator><creator>Principi, Mariabeatrice</creator><creator>Vernia, Piero</creator><creator>Ricci, Chiara</creator><creator>Scribano, Maria L</creator><creator>Bodini, Giorgia</creator><creator>Mazzucco, Dario</creator><creator>Bassotti, Gabrio</creator><creator>Riegler, Gabriele</creator><creator>Buda, Andrea</creator><creator>Neri, Matteo</creator><creator>Caprioli, Flavio</creator><creator>Monica, Fabio</creator><creator>Manca, Aldo</creator><creator>Villa, Erica</creator><creator>Fiorino, Gionata</creator><creator>Comberlato, Michele</creator><creator>Aronico, Nicola</creator><creator>Della Corte, Cristina</creator><creator>Caccaro, Roberta</creator><creator>Gionchetti, Paolo</creator><creator>Giuffrida, Paolo</creator><creator>Iovino, Paola</creator><creator>Lenti, Marco V</creator><creator>Mengoli, Caterina</creator><creator>Pellegrini, Lucienne</creator><creator>Pieraccini, Alberto</creator><creator>Ribaldone, Davide</creator><creator>Testa, Anna</creator><creator>Ubezio, Cristina</creator><creator>Viola, Anna</creator><creator>Vecchi, Maurizio</creator><creator>Klersy, Catherine</creator><creator>Di Sabatino, Antonio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5677-2534</orcidid><orcidid>https://orcid.org/0000-0001-5623-2968</orcidid><orcidid>https://orcid.org/0000-0003-1558-8604</orcidid><orcidid>https://orcid.org/0000-0002-0302-8645</orcidid></search><sort><creationdate>20230105</creationdate><title>Prevalence, Pathogenesis and Management of Anemia in Inflammatory Bowel Disease: An IG-IBD Multicenter, Prospective, and Observational Study</title><author>Bergamaschi, Gaetano ; Castiglione, Fabiana ; D'Incà, Renata ; Astegiano, Marco ; Fries, Walter ; Milla, Monica ; Ciacci, Carolina ; Rizzello, Fernando ; Saibeni, Simone ; Ciccocioppo, Rachele ; Orlando, Ambrogio ; Bossa, Fabrizio ; Principi, Mariabeatrice ; Vernia, Piero ; Ricci, Chiara ; Scribano, Maria L ; Bodini, Giorgia ; Mazzucco, Dario ; Bassotti, Gabrio ; Riegler, Gabriele ; Buda, Andrea ; Neri, Matteo ; Caprioli, Flavio ; Monica, Fabio ; Manca, Aldo ; Villa, Erica ; Fiorino, Gionata ; Comberlato, Michele ; Aronico, Nicola ; Della Corte, Cristina ; Caccaro, Roberta ; Gionchetti, Paolo ; Giuffrida, Paolo ; Iovino, Paola ; Lenti, Marco V ; Mengoli, Caterina ; Pellegrini, Lucienne ; Pieraccini, Alberto ; Ribaldone, Davide ; Testa, Anna ; Ubezio, Cristina ; Viola, Anna ; Vecchi, Maurizio ; Klersy, Catherine ; Di Sabatino, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-f5e04cbe1495c48dfcc55eb9e46abf9ad59beef67df8fd8fb1353e0b669e441d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Anemia - epidemiology</topic><topic>Anemia - etiology</topic><topic>Anemia - therapy</topic><topic>Anemia, Iron-Deficiency - epidemiology</topic><topic>Anemia, Iron-Deficiency - etiology</topic><topic>Anemia, Iron-Deficiency - therapy</topic><topic>Avitaminosis - complications</topic><topic>Fatigue - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Iron Deficiencies</topic><topic>Male</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bergamaschi, Gaetano</creatorcontrib><creatorcontrib>Castiglione, Fabiana</creatorcontrib><creatorcontrib>D'Incà, Renata</creatorcontrib><creatorcontrib>Astegiano, Marco</creatorcontrib><creatorcontrib>Fries, Walter</creatorcontrib><creatorcontrib>Milla, Monica</creatorcontrib><creatorcontrib>Ciacci, Carolina</creatorcontrib><creatorcontrib>Rizzello, Fernando</creatorcontrib><creatorcontrib>Saibeni, Simone</creatorcontrib><creatorcontrib>Ciccocioppo, Rachele</creatorcontrib><creatorcontrib>Orlando, Ambrogio</creatorcontrib><creatorcontrib>Bossa, Fabrizio</creatorcontrib><creatorcontrib>Principi, Mariabeatrice</creatorcontrib><creatorcontrib>Vernia, Piero</creatorcontrib><creatorcontrib>Ricci, Chiara</creatorcontrib><creatorcontrib>Scribano, Maria L</creatorcontrib><creatorcontrib>Bodini, Giorgia</creatorcontrib><creatorcontrib>Mazzucco, Dario</creatorcontrib><creatorcontrib>Bassotti, Gabrio</creatorcontrib><creatorcontrib>Riegler, Gabriele</creatorcontrib><creatorcontrib>Buda, Andrea</creatorcontrib><creatorcontrib>Neri, Matteo</creatorcontrib><creatorcontrib>Caprioli, Flavio</creatorcontrib><creatorcontrib>Monica, Fabio</creatorcontrib><creatorcontrib>Manca, Aldo</creatorcontrib><creatorcontrib>Villa, Erica</creatorcontrib><creatorcontrib>Fiorino, Gionata</creatorcontrib><creatorcontrib>Comberlato, Michele</creatorcontrib><creatorcontrib>Aronico, Nicola</creatorcontrib><creatorcontrib>Della Corte, Cristina</creatorcontrib><creatorcontrib>Caccaro, Roberta</creatorcontrib><creatorcontrib>Gionchetti, Paolo</creatorcontrib><creatorcontrib>Giuffrida, Paolo</creatorcontrib><creatorcontrib>Iovino, Paola</creatorcontrib><creatorcontrib>Lenti, Marco V</creatorcontrib><creatorcontrib>Mengoli, Caterina</creatorcontrib><creatorcontrib>Pellegrini, Lucienne</creatorcontrib><creatorcontrib>Pieraccini, Alberto</creatorcontrib><creatorcontrib>Ribaldone, Davide</creatorcontrib><creatorcontrib>Testa, Anna</creatorcontrib><creatorcontrib>Ubezio, Cristina</creatorcontrib><creatorcontrib>Viola, Anna</creatorcontrib><creatorcontrib>Vecchi, Maurizio</creatorcontrib><creatorcontrib>Klersy, Catherine</creatorcontrib><creatorcontrib>Di Sabatino, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bergamaschi, Gaetano</au><au>Castiglione, Fabiana</au><au>D'Incà, Renata</au><au>Astegiano, Marco</au><au>Fries, Walter</au><au>Milla, Monica</au><au>Ciacci, Carolina</au><au>Rizzello, Fernando</au><au>Saibeni, Simone</au><au>Ciccocioppo, Rachele</au><au>Orlando, Ambrogio</au><au>Bossa, Fabrizio</au><au>Principi, Mariabeatrice</au><au>Vernia, Piero</au><au>Ricci, Chiara</au><au>Scribano, Maria L</au><au>Bodini, Giorgia</au><au>Mazzucco, Dario</au><au>Bassotti, Gabrio</au><au>Riegler, Gabriele</au><au>Buda, Andrea</au><au>Neri, Matteo</au><au>Caprioli, Flavio</au><au>Monica, Fabio</au><au>Manca, Aldo</au><au>Villa, Erica</au><au>Fiorino, Gionata</au><au>Comberlato, Michele</au><au>Aronico, Nicola</au><au>Della Corte, Cristina</au><au>Caccaro, Roberta</au><au>Gionchetti, Paolo</au><au>Giuffrida, Paolo</au><au>Iovino, Paola</au><au>Lenti, Marco V</au><au>Mengoli, Caterina</au><au>Pellegrini, Lucienne</au><au>Pieraccini, Alberto</au><au>Ribaldone, Davide</au><au>Testa, Anna</au><au>Ubezio, Cristina</au><au>Viola, Anna</au><au>Vecchi, Maurizio</au><au>Klersy, Catherine</au><au>Di Sabatino, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence, Pathogenesis and Management of Anemia in Inflammatory Bowel Disease: An IG-IBD Multicenter, Prospective, and Observational Study</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2023-01-05</date><risdate>2023</risdate><volume>29</volume><issue>1</issue><spage>76</spage><epage>84</epage><pages>76-84</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), with a 6% to 74% prevalence and a negative impact on patient survival and quality of life, although the prevalence is apparently declining due to improved disease treatment. We aimed to investigate the prevalence, pathogenesis, and clinical correlates of anemia in Italian patients with IBD.
A multicenter, prospective, observational study, involving 28 Italian gastroenterology centers, was conducted to investigate the epidemiology and consequences of IBD-associated anemia. Clinical and laboratory data of anemic patients were obtained at study enrolment.
Anemia was diagnosed in 737 of 5416 adult IBD outpatients (prevalence 13.6%); females were more commonly affected than males (odds ratio, 1.5; 95% confidence interval [CI], 1.2-1.7) and had more severe anemia. In the majority of cases, anemia was due to iron deficiency (62.5% of cases; 95% CI, 58.3%-66.6%), either isolated or in association with inflammation and/or vitamin deficiencies; anemia of inflammation accounted for only 8.3% of cases. More severe anemia was associated with increasing fatigue and worse quality of life. Only 68.9% of anemic patients with iron deficiency (95% CI, 63.4%-73.8%) and 34.6% of those with vitamin deficiencies (95% CI, 26.2%-44.2%) were properly treated with supplementation therapy.
In Italy, the prevalence of IBD-associated anemia is lower than previously reported. Anemia of IBD is most commonly due to iron deficiency and contributes to fatigue and poor quality of life, but remains untreated in a large proportion of patients with iron and/or vitamin deficiencies. This study is registered at clinicaltrials.gov as NCT02872376.</abstract><cop>England</cop><pmid>35366312</pmid><doi>10.1093/ibd/izac054</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5677-2534</orcidid><orcidid>https://orcid.org/0000-0001-5623-2968</orcidid><orcidid>https://orcid.org/0000-0003-1558-8604</orcidid><orcidid>https://orcid.org/0000-0002-0302-8645</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0998 |
| ispartof | Inflammatory bowel diseases, 2023-01, Vol.29 (1), p.76-84 |
| issn | 1078-0998 1536-4844 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2646725706 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Anemia - epidemiology Anemia - etiology Anemia - therapy Anemia, Iron-Deficiency - epidemiology Anemia, Iron-Deficiency - etiology Anemia, Iron-Deficiency - therapy Avitaminosis - complications Fatigue - etiology Female Humans Inflammation - complications Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - epidemiology Iron Deficiencies Male Prevalence Prospective Studies Quality of Life |
| title | Prevalence, Pathogenesis and Management of Anemia in Inflammatory Bowel Disease: An IG-IBD Multicenter, Prospective, and Observational Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T02%3A10%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence,%20Pathogenesis%20and%20Management%20of%20Anemia%20in%20Inflammatory%20Bowel%20Disease:%20An%20IG-IBD%20Multicenter,%20Prospective,%20and%20Observational%20Study&rft.jtitle=Inflammatory%20bowel%20diseases&rft.au=Bergamaschi,%20Gaetano&rft.date=2023-01-05&rft.volume=29&rft.issue=1&rft.spage=76&rft.epage=84&rft.pages=76-84&rft.issn=1078-0998&rft.eissn=1536-4844&rft_id=info:doi/10.1093/ibd/izac054&rft_dat=%3Cproquest_cross%3E2646725706%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2646725706&rft_id=info:pmid/35366312&rfr_iscdi=true |