Individual variation in buffalo somatic cell cloning efficiency is related to glycolytic metabolism

Mammalian individuals differ in their somatic cell cloning efficiency, but the mechanisms leading to this variation is poorly understood. Here we found that high cloning efficiency buffalo fetal fibroblasts (BFFs) displayed robust energy metabolism, looser chromatin structure, high H3K9 acetylation...

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Veröffentlicht in:	Science China. Life sciences 2022-10, Vol.65 (10), p.2076-2092
Hauptverfasser:	Luo, Chan, Wang, Zhiqiang, Wang, Jinling, Yun, Feng, Lu, Fenghua, Fu, Jiayuan, Liu, Qingyou, Shi, Deshun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Biomedical and Life Sciences Blastocysts Chromatin Cloning Efficiency Embryos Energy metabolism Fetuses Fibroblasts Glycolysis Heterochromatin Histone deacetylase Lactic acid Life Sciences Metabolism Research Paper Somatic cells
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