Attenuation of opioid tolerance by ETA receptor antagonist, BQ123, administered intravenously in mice

Abstract Objectives Intracerebroventricular injection of endothelin-A receptor antagonist BQ123 potentiates opioid analgesia and reverses analgesic tolerance. This study explores whether these effects can be replicated by injecting BQ123 intravenously. Methods Male Swiss-Webster mice were used. Morp...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2022-05, Vol.74 (5), p.769-778
Hauptverfasser:	Bhalla, Shaifali, Lyne, Jaimee, Gulati, Anil, Andurkar, Shridhar V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Analgesics, Opioid - pharmacology Animals Dose-Response Relationship, Drug Drug Tolerance Endothelin A Receptor Antagonists - pharmacology Male Mice Mice, Inbred Strains Morphine - pharmacology Peptides, Cyclic
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