Prediction of the mechanisms of action of Zhibai Dihaung Granule in cisplatin-induced acute kidney injury: A network pharmacology study and experimental validation
Zhibai Dihuang Granule (ZDG) is known as traditional Chinese patent medicine with the functions of “Ziyin decrease internal heat” in Traditional Chinses medicine. In clinical, it is also used to treat various kidney diseases. We aimed to provide a basis for the curative effect of ZDG on acute kidney...
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| Veröffentlicht in: | Journal of ethnopharmacology 2022-06, Vol.292, p.115241-115241, Article 115241 |
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| creator | Liu, Zhen Xu, Ye Bai, Xinming Guo, Lvqian Li, Xinran Gao, Junling Teng, Yuou Yu, Peng |
| description | Zhibai Dihuang Granule (ZDG) is known as traditional Chinese patent medicine with the functions of “Ziyin decrease internal heat” in Traditional Chinses medicine. In clinical, it is also used to treat various kidney diseases.
We aimed to provide a basis for the curative effect of ZDG on acute kidney injury induced by cisplatin (CIAKI).
The active compounds and protein targets of ZDG, as well as the potential targets of the CIAKI were searched from the database. The protein-protein interaction (PPI) network diagram and the drug-compounds-targets-disease network were constructed. Enrichment analysis was performed by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, the effect of ZDG on the prevention and treatment of CIAKI was experimentally validated in vivo and in vitro.
From the database, we screened 22 active compounds of ZDG and 226 related targets. We obtained 498 gene targets related to CIAKI, among which 40 genes overlapped with ZDG-related targets. Go enrichment and KEGG analysis got 339 terms and 64 pathways, respectively. Based on the above study, we speculated that ZDG has the potential effect on treatment CIAKI, and the mechanism may be related to cell apoptosis and inflammation. The results in vitro experiments showed that ZDG reduced the cytotoxicity of cisplatin to HK-2 and 293T cells, but did not affect the antitumor effect of cisplatin. Moreover, in vivo experiments further proved that ZDG effectively controlled kidney damage caused by cisplatin in SD rats. The results showed that ZDG could regulate the expression of CASP3, p65 and MAPK pathway related proteins, suggesting that ZDG's prevention of CIAKI may be related to apoptosis and inflammatory response.
Our study showed that ZDG could prevent and treat CIAKI by inhibiting cell apoptosis and inflammation, which provided a new efficacy and clinical application for ZDG.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2022.115241 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2645473382</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S037887412200280X</els_id><sourcerecordid>2645473382</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-662009583148c4c455392a5d084cd7eccc1d9c22ecd9576341be577d74121f503</originalsourceid><addsrcrecordid>eNp9kc1u1DAURi0EokPhAdggL9lk8G-cwKoqUCpVahewYWN57DuN08QJtlPI8_CieDRtl6ws2ef7bN-D0FtKtpTQ-kO_7WHeMsLYllLJBH2GNrRRrFJS8edoQ7hqqkYJeoJepdQTQhQV5CU64ZJLKpXcoL83EZy32U8BT3ucO8Aj2M4En8Z02DFPZz87vzMef_adWcItvogmLANgH7D1aR5M9qHywS0WXEktGfCddwHWQvRLXD_iMxwg_57iHZ47E0djp2G6XXHKi1uxCQ7DnxmiHyFkM-B7M3hnDpe_Ri_2Zkjw5mE9RT--fvl-_q26ur64PD-7qqygba7qmhHSyoZT0VhhhZS8ZUY60gjrFFhrqWstY2BdK1XNBd2BVMqV-TC6l4SfovfH3jlOvxZIWY8-WRgGE2Bakma1kEJx3rCC0iNq45RShL2ey8NNXDUl-uBG97q40Qc3-uimZN491C-7EdxT4lFGAT4dASifvPcQdbIeQpmnj2CzdpP_T_0_TCahkQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2645473382</pqid></control><display><type>article</type><title>Prediction of the mechanisms of action of Zhibai Dihaung Granule in cisplatin-induced acute kidney injury: A network pharmacology study and experimental validation</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Liu, Zhen ; Xu, Ye ; Bai, Xinming ; Guo, Lvqian ; Li, Xinran ; Gao, Junling ; Teng, Yuou ; Yu, Peng</creator><creatorcontrib>Liu, Zhen ; Xu, Ye ; Bai, Xinming ; Guo, Lvqian ; Li, Xinran ; Gao, Junling ; Teng, Yuou ; Yu, Peng</creatorcontrib><description>Zhibai Dihuang Granule (ZDG) is known as traditional Chinese patent medicine with the functions of “Ziyin decrease internal heat” in Traditional Chinses medicine. In clinical, it is also used to treat various kidney diseases.
We aimed to provide a basis for the curative effect of ZDG on acute kidney injury induced by cisplatin (CIAKI).
The active compounds and protein targets of ZDG, as well as the potential targets of the CIAKI were searched from the database. The protein-protein interaction (PPI) network diagram and the drug-compounds-targets-disease network were constructed. Enrichment analysis was performed by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, the effect of ZDG on the prevention and treatment of CIAKI was experimentally validated in vivo and in vitro.
From the database, we screened 22 active compounds of ZDG and 226 related targets. We obtained 498 gene targets related to CIAKI, among which 40 genes overlapped with ZDG-related targets. Go enrichment and KEGG analysis got 339 terms and 64 pathways, respectively. Based on the above study, we speculated that ZDG has the potential effect on treatment CIAKI, and the mechanism may be related to cell apoptosis and inflammation. The results in vitro experiments showed that ZDG reduced the cytotoxicity of cisplatin to HK-2 and 293T cells, but did not affect the antitumor effect of cisplatin. Moreover, in vivo experiments further proved that ZDG effectively controlled kidney damage caused by cisplatin in SD rats. The results showed that ZDG could regulate the expression of CASP3, p65 and MAPK pathway related proteins, suggesting that ZDG's prevention of CIAKI may be related to apoptosis and inflammatory response.
Our study showed that ZDG could prevent and treat CIAKI by inhibiting cell apoptosis and inflammation, which provided a new efficacy and clinical application for ZDG.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2022.115241</identifier><identifier>PMID: 35351575</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - drug therapy ; Animals ; Cisplatin - toxicity ; Cisplatin-induced acute kidney injury ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Female ; Humans ; Inflammation - drug therapy ; Male ; Medicine, Chinese Traditional - methods ; Molecular Docking Simulation ; Network Pharmacology ; Rats ; Rats, Sprague-Dawley ; Traditional Chinses medicine ; Zhibai Dihuang Granule</subject><ispartof>Journal of ethnopharmacology, 2022-06, Vol.292, p.115241-115241, Article 115241</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-662009583148c4c455392a5d084cd7eccc1d9c22ecd9576341be577d74121f503</citedby><cites>FETCH-LOGICAL-c419t-662009583148c4c455392a5d084cd7eccc1d9c22ecd9576341be577d74121f503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2022.115241$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35351575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zhen</creatorcontrib><creatorcontrib>Xu, Ye</creatorcontrib><creatorcontrib>Bai, Xinming</creatorcontrib><creatorcontrib>Guo, Lvqian</creatorcontrib><creatorcontrib>Li, Xinran</creatorcontrib><creatorcontrib>Gao, Junling</creatorcontrib><creatorcontrib>Teng, Yuou</creatorcontrib><creatorcontrib>Yu, Peng</creatorcontrib><title>Prediction of the mechanisms of action of Zhibai Dihaung Granule in cisplatin-induced acute kidney injury: A network pharmacology study and experimental validation</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Zhibai Dihuang Granule (ZDG) is known as traditional Chinese patent medicine with the functions of “Ziyin decrease internal heat” in Traditional Chinses medicine. In clinical, it is also used to treat various kidney diseases.
We aimed to provide a basis for the curative effect of ZDG on acute kidney injury induced by cisplatin (CIAKI).
The active compounds and protein targets of ZDG, as well as the potential targets of the CIAKI were searched from the database. The protein-protein interaction (PPI) network diagram and the drug-compounds-targets-disease network were constructed. Enrichment analysis was performed by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, the effect of ZDG on the prevention and treatment of CIAKI was experimentally validated in vivo and in vitro.
From the database, we screened 22 active compounds of ZDG and 226 related targets. We obtained 498 gene targets related to CIAKI, among which 40 genes overlapped with ZDG-related targets. Go enrichment and KEGG analysis got 339 terms and 64 pathways, respectively. Based on the above study, we speculated that ZDG has the potential effect on treatment CIAKI, and the mechanism may be related to cell apoptosis and inflammation. The results in vitro experiments showed that ZDG reduced the cytotoxicity of cisplatin to HK-2 and 293T cells, but did not affect the antitumor effect of cisplatin. Moreover, in vivo experiments further proved that ZDG effectively controlled kidney damage caused by cisplatin in SD rats. The results showed that ZDG could regulate the expression of CASP3, p65 and MAPK pathway related proteins, suggesting that ZDG's prevention of CIAKI may be related to apoptosis and inflammatory response.
Our study showed that ZDG could prevent and treat CIAKI by inhibiting cell apoptosis and inflammation, which provided a new efficacy and clinical application for ZDG.
[Display omitted]</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - drug therapy</subject><subject>Animals</subject><subject>Cisplatin - toxicity</subject><subject>Cisplatin-induced acute kidney injury</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Male</subject><subject>Medicine, Chinese Traditional - methods</subject><subject>Molecular Docking Simulation</subject><subject>Network Pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Traditional Chinses medicine</subject><subject>Zhibai Dihuang Granule</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAURi0EokPhAdggL9lk8G-cwKoqUCpVahewYWN57DuN08QJtlPI8_CieDRtl6ws2ef7bN-D0FtKtpTQ-kO_7WHeMsLYllLJBH2GNrRRrFJS8edoQ7hqqkYJeoJepdQTQhQV5CU64ZJLKpXcoL83EZy32U8BT3ucO8Aj2M4En8Z02DFPZz87vzMef_adWcItvogmLANgH7D1aR5M9qHywS0WXEktGfCddwHWQvRLXD_iMxwg_57iHZ47E0djp2G6XXHKi1uxCQ7DnxmiHyFkM-B7M3hnDpe_Ri_2Zkjw5mE9RT--fvl-_q26ur64PD-7qqygba7qmhHSyoZT0VhhhZS8ZUY60gjrFFhrqWstY2BdK1XNBd2BVMqV-TC6l4SfovfH3jlOvxZIWY8-WRgGE2Bakma1kEJx3rCC0iNq45RShL2ey8NNXDUl-uBG97q40Qc3-uimZN491C-7EdxT4lFGAT4dASifvPcQdbIeQpmnj2CzdpP_T_0_TCahkQ</recordid><startdate>20220628</startdate><enddate>20220628</enddate><creator>Liu, Zhen</creator><creator>Xu, Ye</creator><creator>Bai, Xinming</creator><creator>Guo, Lvqian</creator><creator>Li, Xinran</creator><creator>Gao, Junling</creator><creator>Teng, Yuou</creator><creator>Yu, Peng</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220628</creationdate><title>Prediction of the mechanisms of action of Zhibai Dihaung Granule in cisplatin-induced acute kidney injury: A network pharmacology study and experimental validation</title><author>Liu, Zhen ; Xu, Ye ; Bai, Xinming ; Guo, Lvqian ; Li, Xinran ; Gao, Junling ; Teng, Yuou ; Yu, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-662009583148c4c455392a5d084cd7eccc1d9c22ecd9576341be577d74121f503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - drug therapy</topic><topic>Animals</topic><topic>Cisplatin - toxicity</topic><topic>Cisplatin-induced acute kidney injury</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - drug therapy</topic><topic>Male</topic><topic>Medicine, Chinese Traditional - methods</topic><topic>Molecular Docking Simulation</topic><topic>Network Pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Traditional Chinses medicine</topic><topic>Zhibai Dihuang Granule</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Zhen</creatorcontrib><creatorcontrib>Xu, Ye</creatorcontrib><creatorcontrib>Bai, Xinming</creatorcontrib><creatorcontrib>Guo, Lvqian</creatorcontrib><creatorcontrib>Li, Xinran</creatorcontrib><creatorcontrib>Gao, Junling</creatorcontrib><creatorcontrib>Teng, Yuou</creatorcontrib><creatorcontrib>Yu, Peng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zhen</au><au>Xu, Ye</au><au>Bai, Xinming</au><au>Guo, Lvqian</au><au>Li, Xinran</au><au>Gao, Junling</au><au>Teng, Yuou</au><au>Yu, Peng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of the mechanisms of action of Zhibai Dihaung Granule in cisplatin-induced acute kidney injury: A network pharmacology study and experimental validation</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2022-06-28</date><risdate>2022</risdate><volume>292</volume><spage>115241</spage><epage>115241</epage><pages>115241-115241</pages><artnum>115241</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Zhibai Dihuang Granule (ZDG) is known as traditional Chinese patent medicine with the functions of “Ziyin decrease internal heat” in Traditional Chinses medicine. In clinical, it is also used to treat various kidney diseases.
We aimed to provide a basis for the curative effect of ZDG on acute kidney injury induced by cisplatin (CIAKI).
The active compounds and protein targets of ZDG, as well as the potential targets of the CIAKI were searched from the database. The protein-protein interaction (PPI) network diagram and the drug-compounds-targets-disease network were constructed. Enrichment analysis was performed by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, the effect of ZDG on the prevention and treatment of CIAKI was experimentally validated in vivo and in vitro.
From the database, we screened 22 active compounds of ZDG and 226 related targets. We obtained 498 gene targets related to CIAKI, among which 40 genes overlapped with ZDG-related targets. Go enrichment and KEGG analysis got 339 terms and 64 pathways, respectively. Based on the above study, we speculated that ZDG has the potential effect on treatment CIAKI, and the mechanism may be related to cell apoptosis and inflammation. The results in vitro experiments showed that ZDG reduced the cytotoxicity of cisplatin to HK-2 and 293T cells, but did not affect the antitumor effect of cisplatin. Moreover, in vivo experiments further proved that ZDG effectively controlled kidney damage caused by cisplatin in SD rats. The results showed that ZDG could regulate the expression of CASP3, p65 and MAPK pathway related proteins, suggesting that ZDG's prevention of CIAKI may be related to apoptosis and inflammatory response.
Our study showed that ZDG could prevent and treat CIAKI by inhibiting cell apoptosis and inflammation, which provided a new efficacy and clinical application for ZDG.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>35351575</pmid><doi>10.1016/j.jep.2022.115241</doi><tpages>1</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2022-06, Vol.292, p.115241-115241, Article 115241 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Animals Cisplatin - toxicity Cisplatin-induced acute kidney injury Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Female Humans Inflammation - drug therapy Male Medicine, Chinese Traditional - methods Molecular Docking Simulation Network Pharmacology Rats Rats, Sprague-Dawley Traditional Chinses medicine Zhibai Dihuang Granule |
| title | Prediction of the mechanisms of action of Zhibai Dihaung Granule in cisplatin-induced acute kidney injury: A network pharmacology study and experimental validation |
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